Antimicrobial effects of black rice extract on Helicobacter pylori infection in Mongolian gerbil

Sa Hyun Kim, Hyun Jun Woo, Min Ho Lee, Min Park, Tharmalingam Nagendran, Kijong Rhee, Dongsup Lee, Yeung Bae Jin, Sik Won Choi, Woo Duck Seo, Jong Bae Kim

Research output: Contribution to journalArticle

Abstract

It has been reported that cyanidin 3-O-glucoside (C3G) is an inhibitor of Helicobacter pylori toxin secretion. C3G is classified as an anthocyanin and is a major component of black rice extract (BRE). The present study aimed to identify a new functional food material to prevent H. pylori infection in Mongolian gerbil model. Toxicity in the liver and kidney were not detected after BRE administration (10 or 50 mg/kg). BRE treatment reduced bacterial colonization in animal gastric tissue, as well as infection signs as observed on the analysis of the hematological data. It was also found that the relative mRNA levels of the inflammatory cytokines were reduced in BRE-treated groups. These findings suggest that BRE acts as a potent inhibitor of H. pylori infection and pathogenesis in Mongolian gerbils. We propose that BRE may be used to manage gastroduodenal diseases caused by H. pylori infection.

LanguageEnglish
Pages1-5
Number of pages5
JournalJournal of Cereal Science
Volume85
DOIs
Publication statusPublished - 2019 Jan 1

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black rice
Meriones unguiculatus
Helicobacter pylori
Gerbillinae
Helicobacter Infections
anti-infective properties
Anthocyanins
extracts
infection
Liver
Toxicity
Animals
cyanidin
Tissue
Cytokines
Messenger RNA
glucosides
bacterial colonization
nephrotoxicity
Functional Food

All Science Journal Classification (ASJC) codes

  • Food Science
  • Biochemistry

Cite this

Kim, Sa Hyun ; Woo, Hyun Jun ; Lee, Min Ho ; Park, Min ; Nagendran, Tharmalingam ; Rhee, Kijong ; Lee, Dongsup ; Jin, Yeung Bae ; Choi, Sik Won ; Seo, Woo Duck ; Kim, Jong Bae. / Antimicrobial effects of black rice extract on Helicobacter pylori infection in Mongolian gerbil. In: Journal of Cereal Science. 2019 ; Vol. 85. pp. 1-5.
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Kim, SH, Woo, HJ, Lee, MH, Park, M, Nagendran, T, Rhee, K, Lee, D, Jin, YB, Choi, SW, Seo, WD & Kim, JB 2019, 'Antimicrobial effects of black rice extract on Helicobacter pylori infection in Mongolian gerbil' Journal of Cereal Science, vol. 85, pp. 1-5. https://doi.org/10.1016/j.jcs.2018.11.002

Antimicrobial effects of black rice extract on Helicobacter pylori infection in Mongolian gerbil. / Kim, Sa Hyun; Woo, Hyun Jun; Lee, Min Ho; Park, Min; Nagendran, Tharmalingam; Rhee, Kijong; Lee, Dongsup; Jin, Yeung Bae; Choi, Sik Won; Seo, Woo Duck; Kim, Jong Bae.

In: Journal of Cereal Science, Vol. 85, 01.01.2019, p. 1-5.

Research output: Contribution to journalArticle

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