It has been reported that cyanidin 3-O-glucoside (C3G) is an inhibitor of Helicobacter pylori toxin secretion. C3G is classified as an anthocyanin and is a major component of black rice extract (BRE). The present study aimed to identify a new functional food material to prevent H. pylori infection in Mongolian gerbil model. Toxicity in the liver and kidney were not detected after BRE administration (10 or 50 mg/kg). BRE treatment reduced bacterial colonization in animal gastric tissue, as well as infection signs as observed on the analysis of the hematological data. It was also found that the relative mRNA levels of the inflammatory cytokines were reduced in BRE-treated groups. These findings suggest that BRE acts as a potent inhibitor of H. pylori infection and pathogenesis in Mongolian gerbils. We propose that BRE may be used to manage gastroduodenal diseases caused by H. pylori infection.
Bibliographical noteFunding Information:
This work was carried out with the support of the "Cooperative Research Program for Agriculture Science & Technology Development [Project title: Development of aromatic rice and identification of flavor chemicals for export quality, Project No. PJ011647002]" of the Rural Development Administration (RDA), Republic of KOREA .
© 2018 Elsevier Ltd
All Science Journal Classification (ASJC) codes
- Food Science