Antimicrobial Resistance of Neisseria Gonorrhoeae Isolated in Korea

Hyukmin Lee, Kyungwon Lee, Yunsop Chong

Research output: Contribution to journalReview article

Abstract

Neisseria gonorrhoeae is the causative agent of gonorrhea, one of the most important sexually transmitted diseases. The incidence of gonorrhea is still prevalent and about 50,000 new cases have been reported annually during the late 2000s in Korea. The antimicrobial resistance of N. gonorrhoeae is very prevalent and most isolates are multi-drug resistant to penicillin G, tetracycline, and fluoroquinolones. The incidence of penicillinase-producing N. gonorrhoeae (PPNG) decreased significantly, but high-level tetracycline-resistant N. gonorrhoeae (TRNG) increased recently. The minimum inhibitory concentrations (MICs) of ceftriaxone were within the susceptible range for all isolates, but MIC creep has been apparent and one cefixime-nonsusceptible isolate (0.5 μg/ml) was found. Spectinomycin-resistant isolates remain rare, but caution should be required when dealing with gonococcal pharyngitis.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalJournal of Bacteriology and Virology
Volume42
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

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Neisseria gonorrhoeae
Korea
Gonorrhea
Microbial Sensitivity Tests
Tetracycline
Cefixime
Spectinomycin
Penicillinase
Penicillin G
Ceftriaxone
Pharyngitis
Fluoroquinolones
Incidence
Sexually Transmitted Diseases
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

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abstract = "Neisseria gonorrhoeae is the causative agent of gonorrhea, one of the most important sexually transmitted diseases. The incidence of gonorrhea is still prevalent and about 50,000 new cases have been reported annually during the late 2000s in Korea. The antimicrobial resistance of N. gonorrhoeae is very prevalent and most isolates are multi-drug resistant to penicillin G, tetracycline, and fluoroquinolones. The incidence of penicillinase-producing N. gonorrhoeae (PPNG) decreased significantly, but high-level tetracycline-resistant N. gonorrhoeae (TRNG) increased recently. The minimum inhibitory concentrations (MICs) of ceftriaxone were within the susceptible range for all isolates, but MIC creep has been apparent and one cefixime-nonsusceptible isolate (0.5 μg/ml) was found. Spectinomycin-resistant isolates remain rare, but caution should be required when dealing with gonococcal pharyngitis.",
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Antimicrobial Resistance of Neisseria Gonorrhoeae Isolated in Korea. / Lee, Hyukmin; Lee, Kyungwon; Chong, Yunsop.

In: Journal of Bacteriology and Virology, Vol. 42, No. 1, 01.01.2012, p. 9-16.

Research output: Contribution to journalReview article

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