Antimicrobial resistance surveillance of bacteria in 1999 in Korea with a special reference to resistance of enterococci to vancomycin and gram-negative bacilli to third generation cephalosporin, imipenem, and fluoroquinolone

Kyungwon Lee, Hye Soo Lee, Sook Jin Jang, Ae Ja Park, Myung Hee Lee, Won Keun Song, Yunsop Chong

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The trend of antimicrobial resistance of bacteria isolated from patients in 30 Korean hospitals in 1999 was analyzed with a particular attention to cefotaxime-or fluoroquinolone-resistant gram-negative bacilli, imipenem-resistant Pseudomonas aeruginosa, and vancomycin-resistant enterococci. Adequacy of susceptibility testing, and any change in the frequencies of isolated species were also analyzed. The results showed that only 20% and 30% of hospitals tested the piperacillin-tazobactam and cefoxitin susceptibility of Enterobacteriaceae, respectively, only 24% of hospitals the piperacillin-tazobactam susceptibility of P. aeruginosa, and 17% of hospitals the fusidic acid susceptibility of staphylococci. Among the isolates 26.3% were glucose-nonfermenting gram-negative bacilli, and 34.7% of Enterococcus were Enterococcus faecium. Slight decline of cefotaxime-resistance rate to 20% was noted in Klebsiella pneumoniae, while fluoroquinolone-resistantce rate was 68% in Acinetobacter baumannii. The ceftazidime- and imipenem-resistance rates were 17% and 18%, respectively in P. aeruginosa. The vancomycin-resistance rate of E. faecium rose significantly to 15.1%, but the rates varied significantly depending on hospitals suggesting presence of different degree of selective pressure or nosocomial spread. In conclusion, the prevalence of imipenem-resistant P. aeruginosa and the increase of vancomycin-resistant E. faecium were the particularly worrisome phenomena observed in this study.

Original languageEnglish
Pages (from-to)262-270
Number of pages9
JournalJournal of Korean medical science
Volume16
Issue number3
DOIs
Publication statusPublished - 2001 Jun

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Imipenem
Fluoroquinolones
Enterococcus
Cephalosporins
Vancomycin
Korea
Bacillus
Bacteria
Pseudomonas aeruginosa
Enterococcus faecium
Cefotaxime
Vancomycin Resistance
Fusidic Acid
Cefoxitin
Acinetobacter baumannii
Ceftazidime
Klebsiella pneumoniae
Enterobacteriaceae
Staphylococcus
Glucose

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Antimicrobial resistance surveillance of bacteria in 1999 in Korea with a special reference to resistance of enterococci to vancomycin and gram-negative bacilli to third generation cephalosporin, imipenem, and fluoroquinolone",
abstract = "The trend of antimicrobial resistance of bacteria isolated from patients in 30 Korean hospitals in 1999 was analyzed with a particular attention to cefotaxime-or fluoroquinolone-resistant gram-negative bacilli, imipenem-resistant Pseudomonas aeruginosa, and vancomycin-resistant enterococci. Adequacy of susceptibility testing, and any change in the frequencies of isolated species were also analyzed. The results showed that only 20{\%} and 30{\%} of hospitals tested the piperacillin-tazobactam and cefoxitin susceptibility of Enterobacteriaceae, respectively, only 24{\%} of hospitals the piperacillin-tazobactam susceptibility of P. aeruginosa, and 17{\%} of hospitals the fusidic acid susceptibility of staphylococci. Among the isolates 26.3{\%} were glucose-nonfermenting gram-negative bacilli, and 34.7{\%} of Enterococcus were Enterococcus faecium. Slight decline of cefotaxime-resistance rate to 20{\%} was noted in Klebsiella pneumoniae, while fluoroquinolone-resistantce rate was 68{\%} in Acinetobacter baumannii. The ceftazidime- and imipenem-resistance rates were 17{\%} and 18{\%}, respectively in P. aeruginosa. The vancomycin-resistance rate of E. faecium rose significantly to 15.1{\%}, but the rates varied significantly depending on hospitals suggesting presence of different degree of selective pressure or nosocomial spread. In conclusion, the prevalence of imipenem-resistant P. aeruginosa and the increase of vancomycin-resistant E. faecium were the particularly worrisome phenomena observed in this study.",
author = "Kyungwon Lee and Lee, {Hye Soo} and Jang, {Sook Jin} and Park, {Ae Ja} and Lee, {Myung Hee} and Song, {Won Keun} and Yunsop Chong",
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Antimicrobial resistance surveillance of bacteria in 1999 in Korea with a special reference to resistance of enterococci to vancomycin and gram-negative bacilli to third generation cephalosporin, imipenem, and fluoroquinolone. / Lee, Kyungwon; Lee, Hye Soo; Jang, Sook Jin; Park, Ae Ja; Lee, Myung Hee; Song, Won Keun; Chong, Yunsop.

In: Journal of Korean medical science, Vol. 16, No. 3, 06.2001, p. 262-270.

Research output: Contribution to journalArticle

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AU - Lee, Kyungwon

AU - Lee, Hye Soo

AU - Jang, Sook Jin

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AU - Lee, Myung Hee

AU - Song, Won Keun

AU - Chong, Yunsop

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N2 - The trend of antimicrobial resistance of bacteria isolated from patients in 30 Korean hospitals in 1999 was analyzed with a particular attention to cefotaxime-or fluoroquinolone-resistant gram-negative bacilli, imipenem-resistant Pseudomonas aeruginosa, and vancomycin-resistant enterococci. Adequacy of susceptibility testing, and any change in the frequencies of isolated species were also analyzed. The results showed that only 20% and 30% of hospitals tested the piperacillin-tazobactam and cefoxitin susceptibility of Enterobacteriaceae, respectively, only 24% of hospitals the piperacillin-tazobactam susceptibility of P. aeruginosa, and 17% of hospitals the fusidic acid susceptibility of staphylococci. Among the isolates 26.3% were glucose-nonfermenting gram-negative bacilli, and 34.7% of Enterococcus were Enterococcus faecium. Slight decline of cefotaxime-resistance rate to 20% was noted in Klebsiella pneumoniae, while fluoroquinolone-resistantce rate was 68% in Acinetobacter baumannii. The ceftazidime- and imipenem-resistance rates were 17% and 18%, respectively in P. aeruginosa. The vancomycin-resistance rate of E. faecium rose significantly to 15.1%, but the rates varied significantly depending on hospitals suggesting presence of different degree of selective pressure or nosocomial spread. In conclusion, the prevalence of imipenem-resistant P. aeruginosa and the increase of vancomycin-resistant E. faecium were the particularly worrisome phenomena observed in this study.

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