Antimicrobial susceptibility of Stenotrophomonas maltophilia isolates from Korea, and the activity of antimicrobial combinations against the isolates

Hae Sun Chung, Seong Geun Hong, Young Ree Kim, Kyeong Seob Shin, Dong Hee Whang, Jee Young Ahn, Yeon Joon Park, Young Uh, Chulhun L. Chang, Jong Hee Shin, Hye Soo Lee, Kyungwon Lee, Yunsop Chong

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

The aim of this study was to determine antimicrobial susceptibility of recent clinical Stenotrophomonas maltophilia isolates from Korea, and to compare the activity levels of several combinations of antimicrobials. A total of 206 non-duplicate clinical isolates of S. maltophilia was collected in 2010 from 11 university hospitals. Antimicrobial susceptibility testing was performed using the Clinical Laboratory Standards Institute agar dilution method. In vitro activity of antimicrobial combinations was tested using the checkerboard method. The susceptibility rates to trimethoprim-sulfamethoxazole and minocycline were 96% and 99%, respectively. The susceptibility rate to levofloxacin was 64%. All of four antimicrobial combinations showed synergy against many S. maltophilia isolates. A combination of trimethoprim-sulfamethoxazole plus ticarcillin-clavulanate was most synergistic among the combinations. None of the combinations showed antagonistic activity. Therefore, some of the combinations may be more useful than individual drugs in the treatment of S. maltophilia infection. Further clinical studies are warranted to validate our in vitro test results.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalJournal of Korean medical science
Volume28
Issue number1
DOIs
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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