Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Massimo Sartelli; Dieter G. Weber; Etienne Ruppé; Matteo Bassetti; Brian J. Wright; Luca Ansaloni; Fausto Catena; Federico Coccolini; Fikri M. Abu-Zidan; Raul Coimbra; Ernest E. Moore; Frederick A. Moore; Ronald V. Maier; Jan J. De Waele; Andrew W. Kirkpatrick; Ewen A. Griffiths; Christian Eckmann; Adrian J. Brink; John E. Mazuski; Addison K. May; Rob G. Sawyer; Dominik Mertz; Philippe Montravers; Anand Kumar; Jason A. Roberts; Jean Louis Vincent; Richard R. Watkins; Warren Lowman; Brad Spellberg; Iain J. Abbott; Abdulrashid Kayode Adesunkanmi; Sara Al-Dahir; Majdi N. Al-Hasan; Ferdinando Agresta; Asma A. Althani; Shamshul Ansari; Rashid Ansumana; Goran Augustin; Miklosh Bala; Zsolt J. Balogh; Oussama Baraket; Aneel Bhangu; Marcelo A. Beltrán; Michael Bernhard; Walter L. Biffl; Marja A. Boermeester; Stephen M. Brecher; Jill R. Cherry-Bukowiec; Otmar R. Buyne; Miguel A. Cainzos; Kelly A. Cairns; Adrian Camacho-Ortiz; Sujith J. Chandy; Asri Che Jusoh; Alain Chichom-Mefire; Caroline Colijn; Francesco Corcione; Yunfeng Cui; Daniel Curcio; Samir Delibegovic; Zaza Demetrashvili; Belinda De Simone; Sameer Dhingra; José J. Diaz; Isidoro Di Carlo; Angel Dillip; Salomone Di Saverio; Michael P. Doyle; Gereltuya Dorj; Agron Dogjani; Hervé Dupont; Soumitra R. Eachempati; Mushira Abdulaziz Enani; Valery N. Egiev; Mutasim M. Elmangory; Paula Ferrada; Joseph R. Fitchett; Gustavo P. Fraga; Nathalie Guessennd; Helen Giamarellou; Wagih Ghnnam; George Gkiokas; Staphanie R. Goldberg; Carlos Augusto Gomes; Harumi Gomi; Manuel Guzmán-Blanco; Mainul Haque; Sonja Hansen; Andreas Hecker; Wolfgang R. Heizmann; Torsten Herzog; Adrien Montcho Hodonou; Suk Kyung Hong; Reinhold Kafka-Ritsch; Lewis J. Kaplan; Garima Kapoor; Aleksandar Karamarkovic; Martin G. Kees; Jakub Kenig; Ronald Kiguba; Peter K. Kim; Yoram Kluger; Vladimir Khokha; Kaoru Koike; Kenneth Y.Y. Kok; Victory Kong; Matthew C. Knox; Kenji Inaba; Arda Isik; Katia Iskandar; Rao R. Ivatury; Maurizio Labbate; Francesco M. Labricciosa; Pierre François Laterre; Rifat Latifi; Jae Gil Lee; Young Ran Lee; Marc Leone; Ari Leppaniemi; Yousheng Li; Stephen Y. Liang; Tonny Loho; Marc Maegele; Sydney Malama; Hany E. Marei; Ignacio Martin-Loeches; Sanjay Marwah; Amos Massele; Michael McFarlane; Renato Bessa Melo; Ionut Negoi; David P. Nicolau; Carl Erik Nord; Richard Ofori-Asenso; Abdel Karim H. Omari; Carlos A. Ordonez; Mouaqit Ouadii; Gerson Alves Pereira Júnior; Diego Piazza; Guntars Pupelis; Timothy Miles Rawson; Miran Rems; Sandro Rizoli; Claudio Rocha; Boris Sakakhushev; Miguel Sanchez-Garcia; Norio Sato; Helmut A. Segovia Lohse; Gabriele Sganga; Boonying Siribumrungwong; Vishal G. Shelat; Kjetil Soreide; Rodolfo Soto; Peep Talving; Jonathan V. Tilsed; Jean Francois Timsit; Gabriel Trueba; Ngo Tat Trung; Jan Ulrych; Harry van Goor; Andras Vereczkei; Ravinder S. Vohra; Imtiaz Wani; Waldemar Uhl; Yonghong Xiao; Kuo Ching Yuan; Sanoop K. Zachariah; Jean Ralph Zahar; Tanya L. Zakrison; Antonio Corcione; Rita M. Melotti; Claudio Viscoli; Perluigi Viale

doi:10.1186/s13017-016-0089-y

Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

Massimo Sartelli, Dieter G. Weber, Etienne Ruppé, Matteo Bassetti, Brian J. Wright, Luca Ansaloni, Fausto Catena, Federico Coccolini, Fikri M. Abu-Zidan, Raul Coimbra, Ernest E. Moore, Frederick A. Moore, Ronald V. Maier, Jan J. De Waele, Andrew W. Kirkpatrick, Ewen A. Griffiths, Christian Eckmann, Adrian J. Brink, John E. Mazuski, Addison K. MayRob G. Sawyer, Dominik Mertz, Philippe Montravers, Anand Kumar, Jason A. Roberts, Jean Louis Vincent, Richard R. Watkins, Warren Lowman, Brad Spellberg, Iain J. Abbott, Abdulrashid Kayode Adesunkanmi, Sara Al-Dahir, Majdi N. Al-Hasan, Ferdinando Agresta, Asma A. Althani, Shamshul Ansari, Rashid Ansumana, Goran Augustin, Miklosh Bala, Zsolt J. Balogh, Oussama Baraket, Aneel Bhangu, Marcelo A. Beltrán, Michael Bernhard, Walter L. Biffl, Marja A. Boermeester, Stephen M. Brecher, Jill R. Cherry-Bukowiec, Otmar R. Buyne, Miguel A. Cainzos, Kelly A. Cairns, Adrian Camacho-Ortiz, Sujith J. Chandy, Asri Che Jusoh, Alain Chichom-Mefire, Caroline Colijn, Francesco Corcione, Yunfeng Cui, Daniel Curcio, Samir Delibegovic, Zaza Demetrashvili, Belinda De Simone, Sameer Dhingra, José J. Diaz, Isidoro Di Carlo, Angel Dillip, Salomone Di Saverio, Michael P. Doyle, Gereltuya Dorj, Agron Dogjani, Hervé Dupont, Soumitra R. Eachempati, Mushira Abdulaziz Enani, Valery N. Egiev, Mutasim M. Elmangory, Paula Ferrada, Joseph R. Fitchett, Gustavo P. Fraga, Nathalie Guessennd, Helen Giamarellou, Wagih Ghnnam, George Gkiokas, Staphanie R. Goldberg, Carlos Augusto Gomes, Harumi Gomi, Manuel Guzmán-Blanco, Mainul Haque, Sonja Hansen, Andreas Hecker, Wolfgang R. Heizmann, Torsten Herzog, Adrien Montcho Hodonou, Suk Kyung Hong, Reinhold Kafka-Ritsch, Lewis J. Kaplan, Garima Kapoor, Aleksandar Karamarkovic, Martin G. Kees, Jakub Kenig, Ronald Kiguba, Peter K. Kim, Yoram Kluger, Vladimir Khokha, Kaoru Koike, Kenneth Y.Y. Kok, Victory Kong, Matthew C. Knox, Kenji Inaba, Arda Isik, Katia Iskandar, Rao R. Ivatury, Maurizio Labbate, Francesco M. Labricciosa, Pierre François Laterre, Rifat Latifi, Jae Gil Lee, Young Ran Lee, Marc Leone, Ari Leppaniemi, Yousheng Li, Stephen Y. Liang, Tonny Loho, Marc Maegele, Sydney Malama, Hany E. Marei, Ignacio Martin-Loeches, Sanjay Marwah, Amos Massele, Michael McFarlane, Renato Bessa Melo, Ionut Negoi, David P. Nicolau, Carl Erik Nord, Richard Ofori-Asenso, Abdel Karim H. Omari, Carlos A. Ordonez, Mouaqit Ouadii, Gerson Alves Pereira Júnior, Diego Piazza, Guntars Pupelis, Timothy Miles Rawson, Miran Rems, Sandro Rizoli, Claudio Rocha, Boris Sakakhushev, Miguel Sanchez-Garcia, Norio Sato, Helmut A. Segovia Lohse, Gabriele Sganga, Boonying Siribumrungwong, Vishal G. Shelat, Kjetil Soreide, Rodolfo Soto, Peep Talving, Jonathan V. Tilsed, Jean Francois Timsit, Gabriel Trueba, Ngo Tat Trung, Jan Ulrych, Harry van Goor, Andras Vereczkei, Ravinder S. Vohra, Imtiaz Wani, Waldemar Uhl, Yonghong Xiao, Kuo Ching Yuan, Sanoop K. Zachariah, Jean Ralph Zahar, Tanya L. Zakrison, Antonio Corcione, Rita M. Melotti, Claudio Viscoli, Perluigi Viale

Department of Surgery

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Original language	English
Article number	33
Journal	World Journal of Emergency Surgery
Volume	11
Issue number	1
DOIs	https://doi.org/10.1186/s13017-016-0089-y
Publication status	Published - 2016 Jul 15

Bibliographical note

Publisher Copyright:
© 2016 The Author(s).

All Science Journal Classification (ASJC) codes

Surgery
Emergency Medicine

Access to Document

10.1186/s13017-016-0089-y

Cite this

Sartelli, M., Weber, D. G., Ruppé, E., Bassetti, M., Wright, B. J., Ansaloni, L., Catena, F., Coccolini, F., Abu-Zidan, F. M., Coimbra, R., Moore, E. E., Moore, F. A., Maier, R. V., De Waele, J. J., Kirkpatrick, A. W., Griffiths, E. A., Eckmann, C., Brink, A. J., Mazuski, J. E., ... Viale, P. (2016). Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World Journal of Emergency Surgery, 11(1), [33]. https://doi.org/10.1186/s13017-016-0089-y

@article{0a5209657ba645ed86cf6fe262c394be,

title = "Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)",

abstract = "Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.",

author = "Massimo Sartelli and Weber, {Dieter G.} and Etienne Rupp{\'e} and Matteo Bassetti and Wright, {Brian J.} and Luca Ansaloni and Fausto Catena and Federico Coccolini and Abu-Zidan, {Fikri M.} and Raul Coimbra and Moore, {Ernest E.} and Moore, {Frederick A.} and Maier, {Ronald V.} and {De Waele}, {Jan J.} and Kirkpatrick, {Andrew W.} and Griffiths, {Ewen A.} and Christian Eckmann and Brink, {Adrian J.} and Mazuski, {John E.} and May, {Addison K.} and Sawyer, {Rob G.} and Dominik Mertz and Philippe Montravers and Anand Kumar and Roberts, {Jason A.} and Vincent, {Jean Louis} and Watkins, {Richard R.} and Warren Lowman and Brad Spellberg and Abbott, {Iain J.} and Adesunkanmi, {Abdulrashid Kayode} and Sara Al-Dahir and Al-Hasan, {Majdi N.} and Ferdinando Agresta and Althani, {Asma A.} and Shamshul Ansari and Rashid Ansumana and Goran Augustin and Miklosh Bala and Balogh, {Zsolt J.} and Oussama Baraket and Aneel Bhangu and Beltr{\'a}n, {Marcelo A.} and Michael Bernhard and Biffl, {Walter L.} and Boermeester, {Marja A.} and Brecher, {Stephen M.} and Cherry-Bukowiec, {Jill R.} and Buyne, {Otmar R.} and Cainzos, {Miguel A.} and Cairns, {Kelly A.} and Adrian Camacho-Ortiz and Chandy, {Sujith J.} and {Che Jusoh}, Asri and Alain Chichom-Mefire and Caroline Colijn and Francesco Corcione and Yunfeng Cui and Daniel Curcio and Samir Delibegovic and Zaza Demetrashvili and {De Simone}, Belinda and Sameer Dhingra and Diaz, {Jos{\'e} J.} and {Di Carlo}, Isidoro and Angel Dillip and {Di Saverio}, Salomone and Doyle, {Michael P.} and Gereltuya Dorj and Agron Dogjani and Herv{\'e} Dupont and Eachempati, {Soumitra R.} and Enani, {Mushira Abdulaziz} and Egiev, {Valery N.} and Elmangory, {Mutasim M.} and Paula Ferrada and Fitchett, {Joseph R.} and Fraga, {Gustavo P.} and Nathalie Guessennd and Helen Giamarellou and Wagih Ghnnam and George Gkiokas and Goldberg, {Staphanie R.} and Gomes, {Carlos Augusto} and Harumi Gomi and Manuel Guzm{\'a}n-Blanco and Mainul Haque and Sonja Hansen and Andreas Hecker and Heizmann, {Wolfgang R.} and Torsten Herzog and Hodonou, {Adrien Montcho} and Hong, {Suk Kyung} and Reinhold Kafka-Ritsch and Kaplan, {Lewis J.} and Garima Kapoor and Aleksandar Karamarkovic and Kees, {Martin G.} and Jakub Kenig and Ronald Kiguba and Kim, {Peter K.} and Yoram Kluger and Vladimir Khokha and Kaoru Koike and Kok, {Kenneth Y.Y.} and Victory Kong and Knox, {Matthew C.} and Kenji Inaba and Arda Isik and Katia Iskandar and Ivatury, {Rao R.} and Maurizio Labbate and Labricciosa, {Francesco M.} and Laterre, {Pierre Fran{\c c}ois} and Rifat Latifi and Lee, {Jae Gil} and Lee, {Young Ran} and Marc Leone and Ari Leppaniemi and Yousheng Li and Liang, {Stephen Y.} and Tonny Loho and Marc Maegele and Sydney Malama and Marei, {Hany E.} and Ignacio Martin-Loeches and Sanjay Marwah and Amos Massele and Michael McFarlane and Melo, {Renato Bessa} and Ionut Negoi and Nicolau, {David P.} and Nord, {Carl Erik} and Richard Ofori-Asenso and Omari, {Abdel Karim H.} and Ordonez, {Carlos A.} and Mouaqit Ouadii and {Pereira J{\'u}nior}, {Gerson Alves} and Diego Piazza and Guntars Pupelis and Rawson, {Timothy Miles} and Miran Rems and Sandro Rizoli and Claudio Rocha and Boris Sakakhushev and Miguel Sanchez-Garcia and Norio Sato and {Segovia Lohse}, {Helmut A.} and Gabriele Sganga and Boonying Siribumrungwong and Shelat, {Vishal G.} and Kjetil Soreide and Rodolfo Soto and Peep Talving and Tilsed, {Jonathan V.} and Timsit, {Jean Francois} and Gabriel Trueba and Trung, {Ngo Tat} and Jan Ulrych and {van Goor}, Harry and Andras Vereczkei and Vohra, {Ravinder S.} and Imtiaz Wani and Waldemar Uhl and Yonghong Xiao and Yuan, {Kuo Ching} and Zachariah, {Sanoop K.} and Zahar, {Jean Ralph} and Zakrison, {Tanya L.} and Antonio Corcione and Melotti, {Rita M.} and Claudio Viscoli and Perluigi Viale",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

month = jul,

day = "15",

doi = "10.1186/s13017-016-0089-y",

language = "English",

volume = "11",

journal = "World Journal of Emergency Surgery",

issn = "1749-7922",

publisher = "BioMed Central",

number = "1",

}

Sartelli, M, Weber, DG, Ruppé, E, Bassetti, M, Wright, BJ, Ansaloni, L, Catena, F, Coccolini, F, Abu-Zidan, FM, Coimbra, R, Moore, EE, Moore, FA, Maier, RV, De Waele, JJ, Kirkpatrick, AW, Griffiths, EA, Eckmann, C, Brink, AJ, Mazuski, JE, May, AK, Sawyer, RG, Mertz, D, Montravers, P, Kumar, A, Roberts, JA, Vincent, JL, Watkins, RR, Lowman, W, Spellberg, B, Abbott, IJ, Adesunkanmi, AK, Al-Dahir, S, Al-Hasan, MN, Agresta, F, Althani, AA, Ansari, S, Ansumana, R, Augustin, G, Bala, M, Balogh, ZJ, Baraket, O, Bhangu, A, Beltrán, MA, Bernhard, M, Biffl, WL, Boermeester, MA, Brecher, SM, Cherry-Bukowiec, JR, Buyne, OR, Cainzos, MA, Cairns, KA, Camacho-Ortiz, A, Chandy, SJ, Che Jusoh, A, Chichom-Mefire, A, Colijn, C, Corcione, F, Cui, Y, Curcio, D, Delibegovic, S, Demetrashvili, Z, De Simone, B, Dhingra, S, Diaz, JJ, Di Carlo, I, Dillip, A, Di Saverio, S, Doyle, MP, Dorj, G, Dogjani, A, Dupont, H, Eachempati, SR, Enani, MA, Egiev, VN, Elmangory, MM, Ferrada, P, Fitchett, JR, Fraga, GP, Guessennd, N, Giamarellou, H, Ghnnam, W, Gkiokas, G, Goldberg, SR, Gomes, CA, Gomi, H, Guzmán-Blanco, M, Haque, M, Hansen, S, Hecker, A, Heizmann, WR, Herzog, T, Hodonou, AM, Hong, SK, Kafka-Ritsch, R, Kaplan, LJ, Kapoor, G, Karamarkovic, A, Kees, MG, Kenig, J, Kiguba, R, Kim, PK, Kluger, Y, Khokha, V, Koike, K, Kok, KYY, Kong, V, Knox, MC, Inaba, K, Isik, A, Iskandar, K, Ivatury, RR, Labbate, M, Labricciosa, FM, Laterre, PF, Latifi, R, Lee, JG, Lee, YR, Leone, M, Leppaniemi, A, Li, Y, Liang, SY, Loho, T, Maegele, M, Malama, S, Marei, HE, Martin-Loeches, I, Marwah, S, Massele, A, McFarlane, M, Melo, RB, Negoi, I, Nicolau, DP, Nord, CE, Ofori-Asenso, R, Omari, AKH, Ordonez, CA, Ouadii, M, Pereira Júnior, GA, Piazza, D, Pupelis, G, Rawson, TM, Rems, M, Rizoli, S, Rocha, C, Sakakhushev, B, Sanchez-Garcia, M, Sato, N, Segovia Lohse, HA, Sganga, G, Siribumrungwong, B, Shelat, VG, Soreide, K, Soto, R, Talving, P, Tilsed, JV, Timsit, JF, Trueba, G, Trung, NT, Ulrych, J, van Goor, H, Vereczkei, A, Vohra, RS, Wani, I, Uhl, W, Xiao, Y, Yuan, KC, Zachariah, SK, Zahar, JR, Zakrison, TL, Corcione, A, Melotti, RM, Viscoli, C & Viale, P 2016, 'Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)', World Journal of Emergency Surgery, vol. 11, no. 1, 33. https://doi.org/10.1186/s13017-016-0089-y

TY - JOUR

T1 - Antimicrobials

T2 - A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

AU - Sartelli, Massimo

AU - Weber, Dieter G.

AU - Ruppé, Etienne

AU - Bassetti, Matteo

AU - Wright, Brian J.

AU - Ansaloni, Luca

AU - Catena, Fausto

AU - Coccolini, Federico

AU - Abu-Zidan, Fikri M.

AU - Coimbra, Raul

AU - Moore, Ernest E.

AU - Moore, Frederick A.

AU - Maier, Ronald V.

AU - De Waele, Jan J.

AU - Kirkpatrick, Andrew W.

AU - Griffiths, Ewen A.

AU - Eckmann, Christian

AU - Brink, Adrian J.

AU - Mazuski, John E.

AU - May, Addison K.

AU - Sawyer, Rob G.

AU - Mertz, Dominik

AU - Montravers, Philippe

AU - Kumar, Anand

AU - Roberts, Jason A.

AU - Vincent, Jean Louis

AU - Watkins, Richard R.

AU - Lowman, Warren

AU - Spellberg, Brad

AU - Abbott, Iain J.

AU - Adesunkanmi, Abdulrashid Kayode

AU - Al-Dahir, Sara

AU - Al-Hasan, Majdi N.

AU - Agresta, Ferdinando

AU - Althani, Asma A.

AU - Ansari, Shamshul

AU - Ansumana, Rashid

AU - Augustin, Goran

AU - Bala, Miklosh

AU - Balogh, Zsolt J.

AU - Baraket, Oussama

AU - Bhangu, Aneel

AU - Beltrán, Marcelo A.

AU - Bernhard, Michael

AU - Biffl, Walter L.

AU - Boermeester, Marja A.

AU - Brecher, Stephen M.

AU - Cherry-Bukowiec, Jill R.

AU - Buyne, Otmar R.

AU - Cainzos, Miguel A.

AU - Cairns, Kelly A.

AU - Camacho-Ortiz, Adrian

AU - Chandy, Sujith J.

AU - Che Jusoh, Asri

AU - Chichom-Mefire, Alain

AU - Colijn, Caroline

AU - Corcione, Francesco

AU - Cui, Yunfeng

AU - Curcio, Daniel

AU - Delibegovic, Samir

AU - Demetrashvili, Zaza

AU - De Simone, Belinda

AU - Dhingra, Sameer

AU - Diaz, José J.

AU - Di Carlo, Isidoro

AU - Dillip, Angel

AU - Di Saverio, Salomone

AU - Doyle, Michael P.

AU - Dorj, Gereltuya

AU - Dogjani, Agron

AU - Dupont, Hervé

AU - Eachempati, Soumitra R.

AU - Enani, Mushira Abdulaziz

AU - Egiev, Valery N.

AU - Elmangory, Mutasim M.

AU - Ferrada, Paula

AU - Fitchett, Joseph R.

AU - Fraga, Gustavo P.

AU - Guessennd, Nathalie

AU - Giamarellou, Helen

AU - Ghnnam, Wagih

AU - Gkiokas, George

AU - Goldberg, Staphanie R.

AU - Gomes, Carlos Augusto

AU - Gomi, Harumi

AU - Guzmán-Blanco, Manuel

AU - Haque, Mainul

AU - Hansen, Sonja

AU - Hecker, Andreas

AU - Heizmann, Wolfgang R.

AU - Herzog, Torsten

AU - Hodonou, Adrien Montcho

AU - Hong, Suk Kyung

AU - Kafka-Ritsch, Reinhold

AU - Kaplan, Lewis J.

AU - Kapoor, Garima

AU - Karamarkovic, Aleksandar

AU - Kees, Martin G.

AU - Kenig, Jakub

AU - Kiguba, Ronald

AU - Kim, Peter K.

AU - Kluger, Yoram

AU - Khokha, Vladimir

AU - Koike, Kaoru

AU - Kok, Kenneth Y.Y.

AU - Kong, Victory

AU - Knox, Matthew C.

AU - Inaba, Kenji

AU - Isik, Arda

AU - Iskandar, Katia

AU - Ivatury, Rao R.

AU - Labbate, Maurizio

AU - Labricciosa, Francesco M.

AU - Laterre, Pierre François

AU - Latifi, Rifat

AU - Lee, Jae Gil

AU - Lee, Young Ran

AU - Leone, Marc

AU - Leppaniemi, Ari

AU - Li, Yousheng

AU - Liang, Stephen Y.

AU - Loho, Tonny

AU - Maegele, Marc

AU - Malama, Sydney

AU - Marei, Hany E.

AU - Martin-Loeches, Ignacio

AU - Marwah, Sanjay

AU - Massele, Amos

AU - McFarlane, Michael

AU - Melo, Renato Bessa

AU - Negoi, Ionut

AU - Nicolau, David P.

AU - Nord, Carl Erik

AU - Ofori-Asenso, Richard

AU - Omari, Abdel Karim H.

AU - Ordonez, Carlos A.

AU - Ouadii, Mouaqit

AU - Pereira Júnior, Gerson Alves

AU - Piazza, Diego

AU - Pupelis, Guntars

AU - Rawson, Timothy Miles

AU - Rems, Miran

AU - Rizoli, Sandro

AU - Rocha, Claudio

AU - Sakakhushev, Boris

AU - Sanchez-Garcia, Miguel

AU - Sato, Norio

AU - Segovia Lohse, Helmut A.

AU - Sganga, Gabriele

AU - Siribumrungwong, Boonying

AU - Shelat, Vishal G.

AU - Soreide, Kjetil

AU - Soto, Rodolfo

AU - Talving, Peep

AU - Tilsed, Jonathan V.

AU - Timsit, Jean Francois

AU - Trueba, Gabriel

AU - Trung, Ngo Tat

AU - Ulrych, Jan

AU - van Goor, Harry

AU - Vereczkei, Andras

AU - Vohra, Ravinder S.

AU - Wani, Imtiaz

AU - Uhl, Waldemar

AU - Xiao, Yonghong

AU - Yuan, Kuo Ching

AU - Zachariah, Sanoop K.

AU - Zahar, Jean Ralph

AU - Zakrison, Tanya L.

AU - Corcione, Antonio

AU - Melotti, Rita M.

AU - Viscoli, Claudio

AU - Viale, Perluigi

PY - 2016/7/15

Y1 - 2016/7/15

N2 - Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

AB - Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

UR - http://www.scopus.com/inward/record.url?scp=84978923098&partnerID=8YFLogxK

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U2 - 10.1186/s13017-016-0089-y

DO - 10.1186/s13017-016-0089-y

M3 - Article

C2 - 27429642

AN - SCOPUS:84978923098

VL - 11

JO - World Journal of Emergency Surgery

JF - World Journal of Emergency Surgery

SN - 1749-7922

IS - 1

M1 - 33

ER -

Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)

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