Abstract
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
| Original language | English |
|---|---|
| Article number | 33 |
| Journal | World Journal of Emergency Surgery |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2016 Jul 15 |
All Science Journal Classification (ASJC) codes
- Surgery
- Emergency Medicine
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Antimicrobials : A global alliance for optimizing their rational use in intra-abdominal infections (AGORA). / Sartelli, Massimo; Weber, Dieter G.; Ruppé, Etienne; Bassetti, Matteo; Wright, Brian J.; Ansaloni, Luca; Catena, Fausto; Coccolini, Federico; Abu-Zidan, Fikri M.; Coimbra, Raul; Moore, Ernest E.; Moore, Frederick A.; Maier, Ronald V.; De Waele, Jan J.; Kirkpatrick, Andrew W.; Griffiths, Ewen A.; Eckmann, Christian; Brink, Adrian J.; Mazuski, John E.; May, Addison K.; Sawyer, Rob G.; Mertz, Dominik; Montravers, Philippe; Kumar, Anand; Roberts, Jason A.; Vincent, Jean Louis; Watkins, Richard R.; Lowman, Warren; Spellberg, Brad; Abbott, Iain J.; Adesunkanmi, Abdulrashid Kayode; Al-Dahir, Sara; Al-Hasan, Majdi N.; Agresta, Ferdinando; Althani, Asma A.; Ansari, Shamshul; Ansumana, Rashid; Augustin, Goran; Bala, Miklosh; Balogh, Zsolt J.; Baraket, Oussama; Bhangu, Aneel; Beltrán, Marcelo A.; Bernhard, Michael; Biffl, Walter L.; Boermeester, Marja A.; Brecher, Stephen M.; Cherry-Bukowiec, Jill R.; Buyne, Otmar R.; Cainzos, Miguel A.; Cairns, Kelly A.; Camacho-Ortiz, Adrian; Chandy, Sujith J.; Che Jusoh, Asri; Chichom-Mefire, Alain; Colijn, Caroline; Corcione, Francesco; Cui, Yunfeng; Curcio, Daniel; Delibegovic, Samir; Demetrashvili, Zaza; De Simone, Belinda; Dhingra, Sameer; Diaz, José J.; Di Carlo, Isidoro; Dillip, Angel; Di Saverio, Salomone; Doyle, Michael P.; Dorj, Gereltuya; Dogjani, Agron; Dupont, Hervé; Eachempati, Soumitra R.; Enani, Mushira Abdulaziz; Egiev, Valery N.; Elmangory, Mutasim M.; Ferrada, Paula; Fitchett, Joseph R.; Fraga, Gustavo P.; Guessennd, Nathalie; Giamarellou, Helen; Ghnnam, Wagih; Gkiokas, George; Goldberg, Staphanie R.; Gomes, Carlos Augusto; Gomi, Harumi; Guzmán-Blanco, Manuel; Haque, Mainul; Hansen, Sonja; Hecker, Andreas; Heizmann, Wolfgang R.; Herzog, Torsten; Hodonou, Adrien Montcho; Hong, Suk Kyung; Kafka-Ritsch, Reinhold; Kaplan, Lewis J.; Kapoor, Garima; Karamarkovic, Aleksandar; Kees, Martin G.; Kenig, Jakub; Kiguba, Ronald; Kim, Peter K.; Kluger, Yoram; Khokha, Vladimir; Koike, Kaoru; Kok, Kenneth Y.Y.; Kong, Victory; Knox, Matthew C.; Inaba, Kenji; Isik, Arda; Iskandar, Katia; Ivatury, Rao R.; Labbate, Maurizio; Labricciosa, Francesco M.; Laterre, Pierre François; Latifi, Rifat; Lee, Jae Gil; Lee, Young Ran; Leone, Marc; Leppaniemi, Ari; Li, Yousheng; Liang, Stephen Y.; Loho, Tonny; Maegele, Marc; Malama, Sydney; Marei, Hany E.; Martin-Loeches, Ignacio; Marwah, Sanjay; Massele, Amos; McFarlane, Michael; Melo, Renato Bessa; Negoi, Ionut; Nicolau, David P.; Nord, Carl Erik; Ofori-Asenso, Richard; Omari, Abdel Karim H.; Ordonez, Carlos A.; Ouadii, Mouaqit; Pereira Júnior, Gerson Alves; Piazza, Diego; Pupelis, Guntars; Rawson, Timothy Miles; Rems, Miran; Rizoli, Sandro; Rocha, Claudio; Sakakhushev, Boris; Sanchez-Garcia, Miguel; Sato, Norio; Segovia Lohse, Helmut A.; Sganga, Gabriele; Siribumrungwong, Boonying; Shelat, Vishal G.; Soreide, Kjetil; Soto, Rodolfo; Talving, Peep; Tilsed, Jonathan V.; Timsit, Jean Francois; Trueba, Gabriel; Trung, Ngo Tat; Ulrych, Jan; van Goor, Harry; Vereczkei, Andras; Vohra, Ravinder S.; Wani, Imtiaz; Uhl, Waldemar; Xiao, Yonghong; Yuan, Kuo Ching; Zachariah, Sanoop K.; Zahar, Jean Ralph; Zakrison, Tanya L.; Corcione, Antonio; Melotti, Rita M.; Viscoli, Claudio; Viale, Perluigi.
In: World Journal of Emergency Surgery, Vol. 11, No. 1, 33, 15.07.2016.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Antimicrobials
T2 - A global alliance for optimizing their rational use in intra-abdominal infections (AGORA)
AU - Sartelli, Massimo
AU - Weber, Dieter G.
AU - Ruppé, Etienne
AU - Bassetti, Matteo
AU - Wright, Brian J.
AU - Ansaloni, Luca
AU - Catena, Fausto
AU - Coccolini, Federico
AU - Abu-Zidan, Fikri M.
AU - Coimbra, Raul
AU - Moore, Ernest E.
AU - Moore, Frederick A.
AU - Maier, Ronald V.
AU - De Waele, Jan J.
AU - Kirkpatrick, Andrew W.
AU - Griffiths, Ewen A.
AU - Eckmann, Christian
AU - Brink, Adrian J.
AU - Mazuski, John E.
AU - May, Addison K.
AU - Sawyer, Rob G.
AU - Mertz, Dominik
AU - Montravers, Philippe
AU - Kumar, Anand
AU - Roberts, Jason A.
AU - Vincent, Jean Louis
AU - Watkins, Richard R.
AU - Lowman, Warren
AU - Spellberg, Brad
AU - Abbott, Iain J.
AU - Adesunkanmi, Abdulrashid Kayode
AU - Al-Dahir, Sara
AU - Al-Hasan, Majdi N.
AU - Agresta, Ferdinando
AU - Althani, Asma A.
AU - Ansari, Shamshul
AU - Ansumana, Rashid
AU - Augustin, Goran
AU - Bala, Miklosh
AU - Balogh, Zsolt J.
AU - Baraket, Oussama
AU - Bhangu, Aneel
AU - Beltrán, Marcelo A.
AU - Bernhard, Michael
AU - Biffl, Walter L.
AU - Boermeester, Marja A.
AU - Brecher, Stephen M.
AU - Cherry-Bukowiec, Jill R.
AU - Buyne, Otmar R.
AU - Cainzos, Miguel A.
AU - Cairns, Kelly A.
AU - Camacho-Ortiz, Adrian
AU - Chandy, Sujith J.
AU - Che Jusoh, Asri
AU - Chichom-Mefire, Alain
AU - Colijn, Caroline
AU - Corcione, Francesco
AU - Cui, Yunfeng
AU - Curcio, Daniel
AU - Delibegovic, Samir
AU - Demetrashvili, Zaza
AU - De Simone, Belinda
AU - Dhingra, Sameer
AU - Diaz, José J.
AU - Di Carlo, Isidoro
AU - Dillip, Angel
AU - Di Saverio, Salomone
AU - Doyle, Michael P.
AU - Dorj, Gereltuya
AU - Dogjani, Agron
AU - Dupont, Hervé
AU - Eachempati, Soumitra R.
AU - Enani, Mushira Abdulaziz
AU - Egiev, Valery N.
AU - Elmangory, Mutasim M.
AU - Ferrada, Paula
AU - Fitchett, Joseph R.
AU - Fraga, Gustavo P.
AU - Guessennd, Nathalie
AU - Giamarellou, Helen
AU - Ghnnam, Wagih
AU - Gkiokas, George
AU - Goldberg, Staphanie R.
AU - Gomes, Carlos Augusto
AU - Gomi, Harumi
AU - Guzmán-Blanco, Manuel
AU - Haque, Mainul
AU - Hansen, Sonja
AU - Hecker, Andreas
AU - Heizmann, Wolfgang R.
AU - Herzog, Torsten
AU - Hodonou, Adrien Montcho
AU - Hong, Suk Kyung
AU - Kafka-Ritsch, Reinhold
AU - Kaplan, Lewis J.
AU - Kapoor, Garima
AU - Karamarkovic, Aleksandar
AU - Kees, Martin G.
AU - Kenig, Jakub
AU - Kiguba, Ronald
AU - Kim, Peter K.
AU - Kluger, Yoram
AU - Khokha, Vladimir
AU - Koike, Kaoru
AU - Kok, Kenneth Y.Y.
AU - Kong, Victory
AU - Knox, Matthew C.
AU - Inaba, Kenji
AU - Isik, Arda
AU - Iskandar, Katia
AU - Ivatury, Rao R.
AU - Labbate, Maurizio
AU - Labricciosa, Francesco M.
AU - Laterre, Pierre François
AU - Latifi, Rifat
AU - Lee, Jae Gil
AU - Lee, Young Ran
AU - Leone, Marc
AU - Leppaniemi, Ari
AU - Li, Yousheng
AU - Liang, Stephen Y.
AU - Loho, Tonny
AU - Maegele, Marc
AU - Malama, Sydney
AU - Marei, Hany E.
AU - Martin-Loeches, Ignacio
AU - Marwah, Sanjay
AU - Massele, Amos
AU - McFarlane, Michael
AU - Melo, Renato Bessa
AU - Negoi, Ionut
AU - Nicolau, David P.
AU - Nord, Carl Erik
AU - Ofori-Asenso, Richard
AU - Omari, Abdel Karim H.
AU - Ordonez, Carlos A.
AU - Ouadii, Mouaqit
AU - Pereira Júnior, Gerson Alves
AU - Piazza, Diego
AU - Pupelis, Guntars
AU - Rawson, Timothy Miles
AU - Rems, Miran
AU - Rizoli, Sandro
AU - Rocha, Claudio
AU - Sakakhushev, Boris
AU - Sanchez-Garcia, Miguel
AU - Sato, Norio
AU - Segovia Lohse, Helmut A.
AU - Sganga, Gabriele
AU - Siribumrungwong, Boonying
AU - Shelat, Vishal G.
AU - Soreide, Kjetil
AU - Soto, Rodolfo
AU - Talving, Peep
AU - Tilsed, Jonathan V.
AU - Timsit, Jean Francois
AU - Trueba, Gabriel
AU - Trung, Ngo Tat
AU - Ulrych, Jan
AU - van Goor, Harry
AU - Vereczkei, Andras
AU - Vohra, Ravinder S.
AU - Wani, Imtiaz
AU - Uhl, Waldemar
AU - Xiao, Yonghong
AU - Yuan, Kuo Ching
AU - Zachariah, Sanoop K.
AU - Zahar, Jean Ralph
AU - Zakrison, Tanya L.
AU - Corcione, Antonio
AU - Melotti, Rita M.
AU - Viscoli, Claudio
AU - Viale, Perluigi
N1 - Publisher Copyright: © 2016 The Author(s). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/7/15
Y1 - 2016/7/15
N2 - Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
AB - Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.
UR - http://www.scopus.com/inward/record.url?scp=84978923098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978923098&partnerID=8YFLogxK
U2 - 10.1186/s13017-016-0089-y
DO - 10.1186/s13017-016-0089-y
M3 - Article
C2 - 27429642
AN - SCOPUS:84978923098
VL - 11
JO - World Journal of Emergency Surgery
JF - World Journal of Emergency Surgery
SN - 1749-7922
IS - 1
M1 - 33
ER -