Antinuclear antibodies in patients with Behçet's disease

Eun Young Chun, Sang Gun Park, Young Hun Cho, Ju Hee Lee, Kwang Hoon Lee, Dong Sik Bang, Eun So Lee, Sung Nack Lee

Research output: Contribution to journalArticle

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Abstract

Background: Behçet's disease has features consistent with an immunopathogenic mechanism, but the autoreactivity in pathogenesis is unclear. Objective: This study was to investigate the association of antinuclear antibodies (ANA) with Behçet's disease. Methods: The patients in this study were diagnosed at Severance Hospital Behçet's Disease Specialty Clinic from May, 1998 to May, 2002. We evaluated the frequency, titers and immunofluorescence patterns of ANA in patients with Behçet's disease, and compared the frequency with a healthy control group. According to the positivity of ANA, we compared the frequency of minor symptoms to investigate the association of the severity of disease with ANA. Results: 1. Of the 554 cases of Behçet's disease, 46 cases (8.3%) were ANA positive, however, of the 271 cases of healthy control group, only 5 cases (1.8%) were ANA positive. (p=0.0003) 2. In ANA titers 38 cases (82.6%) showed low titer (1:40+, 1:160-), 5 cases (10.9%) intermediate titer (1:160+, 1:640-), and 3 cases high titer (>1:640+). There was no significant difference in intermediate and high titers between complete (17.9%) and incomplete type (14.3%). 3. In immunofluorescence patterns of ANA, 17 cases (37%) were speckled pattern, 5 cases (10.9%) homogeneous pattern, 3 cases (6.5%) centromere pattern, 2 cases (4.3%) nucleolar pattern and 19 cases (41.3%) unknown pattern. 4. Of 508 cases with negative ANA patients, 272 cases (53.5%) had minor symptoms, however, of 46 cases with positive ANA patients, 14 cases (30.4%) had minor symptoms (p=0.0027). Conclusion: From this study ANA was more prevalent in Behçet's disease. However, it was not related to severity of disease and most of them were low titer. ANA, herein, might play a minor role in pathogenesis of Behçet's disease.

Original languageEnglish
Pages (from-to)545-550
Number of pages6
JournalKorean Journal of Dermatology
Volume42
Issue number5
Publication statusPublished - 2004 May 1

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Antinuclear Antibodies
Fluorescent Antibody Technique
Control Groups
Centromere

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Chun, E. Y., Park, S. G., Cho, Y. H., Lee, J. H., Lee, K. H., Bang, D. S., ... Lee, S. N. (2004). Antinuclear antibodies in patients with Behçet's disease. Korean Journal of Dermatology, 42(5), 545-550.
Chun, Eun Young ; Park, Sang Gun ; Cho, Young Hun ; Lee, Ju Hee ; Lee, Kwang Hoon ; Bang, Dong Sik ; Lee, Eun So ; Lee, Sung Nack. / Antinuclear antibodies in patients with Behçet's disease. In: Korean Journal of Dermatology. 2004 ; Vol. 42, No. 5. pp. 545-550.
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title = "Antinuclear antibodies in patients with Beh{\cc}et's disease",
abstract = "Background: Beh{\cc}et's disease has features consistent with an immunopathogenic mechanism, but the autoreactivity in pathogenesis is unclear. Objective: This study was to investigate the association of antinuclear antibodies (ANA) with Beh{\cc}et's disease. Methods: The patients in this study were diagnosed at Severance Hospital Beh{\cc}et's Disease Specialty Clinic from May, 1998 to May, 2002. We evaluated the frequency, titers and immunofluorescence patterns of ANA in patients with Beh{\cc}et's disease, and compared the frequency with a healthy control group. According to the positivity of ANA, we compared the frequency of minor symptoms to investigate the association of the severity of disease with ANA. Results: 1. Of the 554 cases of Beh{\cc}et's disease, 46 cases (8.3{\%}) were ANA positive, however, of the 271 cases of healthy control group, only 5 cases (1.8{\%}) were ANA positive. (p=0.0003) 2. In ANA titers 38 cases (82.6{\%}) showed low titer (1:40+, 1:160-), 5 cases (10.9{\%}) intermediate titer (1:160+, 1:640-), and 3 cases high titer (>1:640+). There was no significant difference in intermediate and high titers between complete (17.9{\%}) and incomplete type (14.3{\%}). 3. In immunofluorescence patterns of ANA, 17 cases (37{\%}) were speckled pattern, 5 cases (10.9{\%}) homogeneous pattern, 3 cases (6.5{\%}) centromere pattern, 2 cases (4.3{\%}) nucleolar pattern and 19 cases (41.3{\%}) unknown pattern. 4. Of 508 cases with negative ANA patients, 272 cases (53.5{\%}) had minor symptoms, however, of 46 cases with positive ANA patients, 14 cases (30.4{\%}) had minor symptoms (p=0.0027). Conclusion: From this study ANA was more prevalent in Beh{\cc}et's disease. However, it was not related to severity of disease and most of them were low titer. ANA, herein, might play a minor role in pathogenesis of Beh{\cc}et's disease.",
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Chun, EY, Park, SG, Cho, YH, Lee, JH, Lee, KH, Bang, DS, Lee, ES & Lee, SN 2004, 'Antinuclear antibodies in patients with Behçet's disease', Korean Journal of Dermatology, vol. 42, no. 5, pp. 545-550.

Antinuclear antibodies in patients with Behçet's disease. / Chun, Eun Young; Park, Sang Gun; Cho, Young Hun; Lee, Ju Hee; Lee, Kwang Hoon; Bang, Dong Sik; Lee, Eun So; Lee, Sung Nack.

In: Korean Journal of Dermatology, Vol. 42, No. 5, 01.05.2004, p. 545-550.

Research output: Contribution to journalArticle

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T1 - Antinuclear antibodies in patients with Behçet's disease

AU - Chun, Eun Young

AU - Park, Sang Gun

AU - Cho, Young Hun

AU - Lee, Ju Hee

AU - Lee, Kwang Hoon

AU - Bang, Dong Sik

AU - Lee, Eun So

AU - Lee, Sung Nack

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N2 - Background: Behçet's disease has features consistent with an immunopathogenic mechanism, but the autoreactivity in pathogenesis is unclear. Objective: This study was to investigate the association of antinuclear antibodies (ANA) with Behçet's disease. Methods: The patients in this study were diagnosed at Severance Hospital Behçet's Disease Specialty Clinic from May, 1998 to May, 2002. We evaluated the frequency, titers and immunofluorescence patterns of ANA in patients with Behçet's disease, and compared the frequency with a healthy control group. According to the positivity of ANA, we compared the frequency of minor symptoms to investigate the association of the severity of disease with ANA. Results: 1. Of the 554 cases of Behçet's disease, 46 cases (8.3%) were ANA positive, however, of the 271 cases of healthy control group, only 5 cases (1.8%) were ANA positive. (p=0.0003) 2. In ANA titers 38 cases (82.6%) showed low titer (1:40+, 1:160-), 5 cases (10.9%) intermediate titer (1:160+, 1:640-), and 3 cases high titer (>1:640+). There was no significant difference in intermediate and high titers between complete (17.9%) and incomplete type (14.3%). 3. In immunofluorescence patterns of ANA, 17 cases (37%) were speckled pattern, 5 cases (10.9%) homogeneous pattern, 3 cases (6.5%) centromere pattern, 2 cases (4.3%) nucleolar pattern and 19 cases (41.3%) unknown pattern. 4. Of 508 cases with negative ANA patients, 272 cases (53.5%) had minor symptoms, however, of 46 cases with positive ANA patients, 14 cases (30.4%) had minor symptoms (p=0.0027). Conclusion: From this study ANA was more prevalent in Behçet's disease. However, it was not related to severity of disease and most of them were low titer. ANA, herein, might play a minor role in pathogenesis of Behçet's disease.

AB - Background: Behçet's disease has features consistent with an immunopathogenic mechanism, but the autoreactivity in pathogenesis is unclear. Objective: This study was to investigate the association of antinuclear antibodies (ANA) with Behçet's disease. Methods: The patients in this study were diagnosed at Severance Hospital Behçet's Disease Specialty Clinic from May, 1998 to May, 2002. We evaluated the frequency, titers and immunofluorescence patterns of ANA in patients with Behçet's disease, and compared the frequency with a healthy control group. According to the positivity of ANA, we compared the frequency of minor symptoms to investigate the association of the severity of disease with ANA. Results: 1. Of the 554 cases of Behçet's disease, 46 cases (8.3%) were ANA positive, however, of the 271 cases of healthy control group, only 5 cases (1.8%) were ANA positive. (p=0.0003) 2. In ANA titers 38 cases (82.6%) showed low titer (1:40+, 1:160-), 5 cases (10.9%) intermediate titer (1:160+, 1:640-), and 3 cases high titer (>1:640+). There was no significant difference in intermediate and high titers between complete (17.9%) and incomplete type (14.3%). 3. In immunofluorescence patterns of ANA, 17 cases (37%) were speckled pattern, 5 cases (10.9%) homogeneous pattern, 3 cases (6.5%) centromere pattern, 2 cases (4.3%) nucleolar pattern and 19 cases (41.3%) unknown pattern. 4. Of 508 cases with negative ANA patients, 272 cases (53.5%) had minor symptoms, however, of 46 cases with positive ANA patients, 14 cases (30.4%) had minor symptoms (p=0.0027). Conclusion: From this study ANA was more prevalent in Behçet's disease. However, it was not related to severity of disease and most of them were low titer. ANA, herein, might play a minor role in pathogenesis of Behçet's disease.

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Chun EY, Park SG, Cho YH, Lee JH, Lee KH, Bang DS et al. Antinuclear antibodies in patients with Behçet's disease. Korean Journal of Dermatology. 2004 May 1;42(5):545-550.