Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia

Chol Seung Lim, Da Qing Jin, Hyejung Mok, Sang Jin Oh, Jung Uk Lee, Jae-Kwan Hwang, Ilho Ha, Jung Soo Han

Research output: Contribution to journalArticle

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Abstract

Xanthorrhizol, a natural sesquiterpenoid isolated from the rhizome of Curcuma xanthorrhiza Roxb (Zingiberaceae), has antibacterial activities and protective effects against cisplatin-induced hepatotoxicity. In this study, we investigated the activities of xanthorrhizol as an antioxidant or antiinflammatory agent using neuronal and microglial cells. Xanthorrhizol had potent neuroprotective effects on glutamate-induced neurotoxicity and reactive oxygen species (ROS) generation in the murine hippocampal HT22 cell line. Also, xanthorrhizol inhibited H2O2-induced lipid peroxidation in rat brain homogenates. The properties of xanthorrhizol as an antiinflammatory agent were investigated in microglial activation by lipopolysaccharide. It reduced the expression of cyclooxygenase-2 and the inducible nitric oxide synthase, which consequently resulted in the reduction of nitric oxide. The production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor-α in activated microglial cells, was reduced by xanthorrhizol. These results suggest that xanthorrhizol could be an effective candidate for the treatment of Alzheimer's disease- and other neurological disease-related ROS and inflammation.

Original languageEnglish
Pages (from-to)831-838
Number of pages8
JournalJournal of Neuroscience Research
Volume82
Issue number6
DOIs
Publication statusPublished - 2005 Dec 15

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Microglia
Anti-Inflammatory Agents
Antioxidants
Neurons
Reactive Oxygen Species
Zingiberaceae
Curcuma
Rhizome
Neuroprotective Agents
Nitric Oxide Synthase Type II
Cyclooxygenase 2
xanthorrhizol
Cisplatin
Lipid Peroxidation
Lipopolysaccharides
Glutamic Acid
Interleukin-6
Alzheimer Disease
Nitric Oxide
Tumor Necrosis Factor-alpha

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

Cite this

Lim, Chol Seung ; Jin, Da Qing ; Mok, Hyejung ; Oh, Sang Jin ; Lee, Jung Uk ; Hwang, Jae-Kwan ; Ha, Ilho ; Han, Jung Soo. / Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia. In: Journal of Neuroscience Research. 2005 ; Vol. 82, No. 6. pp. 831-838.
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Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia. / Lim, Chol Seung; Jin, Da Qing; Mok, Hyejung; Oh, Sang Jin; Lee, Jung Uk; Hwang, Jae-Kwan; Ha, Ilho; Han, Jung Soo.

In: Journal of Neuroscience Research, Vol. 82, No. 6, 15.12.2005, p. 831-838.

Research output: Contribution to journalArticle

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