Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator

Ji Won Choi, Su Jeong Shin, Hyeon Ji Kim, Jong Hyun Park, Hyeon Jeong Kim, Elijah Hwejin Lee, Ae Nim Pae, Yong Sun Bahn, Ki Duk Park

Research output: Contribution to journalArticle

Abstract

The main pathway responsible for cellular regulation against oxidative stress is nuclear factor E2-related factor-2 (Nrf2) signaling. We previously synthesized and reported a novel vinyl sulfone (1) as an Nrf2 activator with therapeutic potential for Parkinson's disease (PD). In this study, we changed the vinyl sulfone to vinyl sulfonamide or vinyl sulfonate to improve Nrf2 activating efficacy. We observed that the introduction of vinyl sulfonamide led to a reduction of the effects on Nrf2 activation, whereas vinyl sulfonate compounds exhibited superior activity compared to the vinyl sulfone compounds. Among the vinyl sulfonates, 3c exhibited 6.9- and 83.5-fold higher effects on Nrf2 activation than the corresponding vinyl sulfone (1) and vinyl sulfonamide (2c), respectively. Compound 3c was confirmed to induce expression of the Nrf2-dependent antioxidant enzymes at the protein level in cells. In addition, 3c mitigated PD-associated behavioral deficits by protecting DAergic neurons in the MPTP-induced mouse model of PD.

Original languageEnglish
Pages (from-to)1061-1067
Number of pages7
JournalACS Medicinal Chemistry Letters
Volume10
Issue number7
DOIs
Publication statusPublished - 2019 Jul 11

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Vinyl Compounds
NF-E2-Related Factor 2
Neuroprotective Agents
Anti-Inflammatory Agents
Antioxidants
Parkinson Disease
Chemical activation
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Oxidative stress
Neurons
Oxidative Stress
divinyl sulfone
Enzymes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Choi, Ji Won ; Shin, Su Jeong ; Kim, Hyeon Ji ; Park, Jong Hyun ; Kim, Hyeon Jeong ; Lee, Elijah Hwejin ; Pae, Ae Nim ; Bahn, Yong Sun ; Park, Ki Duk. / Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator. In: ACS Medicinal Chemistry Letters. 2019 ; Vol. 10, No. 7. pp. 1061-1067.
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Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator. / Choi, Ji Won; Shin, Su Jeong; Kim, Hyeon Ji; Park, Jong Hyun; Kim, Hyeon Jeong; Lee, Elijah Hwejin; Pae, Ae Nim; Bahn, Yong Sun; Park, Ki Duk.

In: ACS Medicinal Chemistry Letters, Vol. 10, No. 7, 11.07.2019, p. 1061-1067.

Research output: Contribution to journalArticle

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