Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives

Taegwon Oh; Aisal Hayat; Euna Yoo; Sang Nae Cho; Yhun Yhung Sheen; Dae Kee Kim; Hea Young Park Choo

doi:10.1002/bkcs.10009

Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives

Taegwon Oh, Aisal Hayat, Euna Yoo, Sang Nae Cho, Yhun Yhung Sheen, Dae Kee Kim, Hea Young Park Choo

Department of Microbiology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

1,2,4-Triazoles exert antimycobacterial activity by inhibiting the cell wall biosynthesis. In an attempt to developing lead compounds exhibiting antitubercular activities, a series of 1,2,4-triazole derivatives were synthesized by introducing various substitutes into a scaffold and the antitubercular activity was evaluated. The most potent compounds 3e and 8d showed their minimum inhibitory concentrations against Mycobacterium tuberculosis as 12.5 μM. The results indicate that those compounds can be considered as leads for further development of new 1,2,4-triazole type candidates with high antitubercular activities.

Original language	English
Pages (from-to)	43-51
Number of pages	9
Journal	Bulletin of the Korean Chemical Society
Volume	36
Issue number	1
DOIs	https://doi.org/10.1002/bkcs.10009
Publication status	Published - 2015 Jan 20

Bibliographical note

Publisher Copyright:
© 2015 Korean Chemical Society, Seoul & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

All Science Journal Classification (ASJC) codes

Chemistry(all)

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title = "Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives",

abstract = "1,2,4-Triazoles exert antimycobacterial activity by inhibiting the cell wall biosynthesis. In an attempt to developing lead compounds exhibiting antitubercular activities, a series of 1,2,4-triazole derivatives were synthesized by introducing various substitutes into a scaffold and the antitubercular activity was evaluated. The most potent compounds 3e and 8d showed their minimum inhibitory concentrations against Mycobacterium tuberculosis as 12.5 μM. The results indicate that those compounds can be considered as leads for further development of new 1,2,4-triazole type candidates with high antitubercular activities.",

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AU - Oh, Taegwon

AU - Hayat, Aisal

AU - Yoo, Euna

AU - Cho, Sang Nae

AU - Sheen, Yhun Yhung

AU - Kim, Dae Kee

AU - Choo, Hea Young Park

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N2 - 1,2,4-Triazoles exert antimycobacterial activity by inhibiting the cell wall biosynthesis. In an attempt to developing lead compounds exhibiting antitubercular activities, a series of 1,2,4-triazole derivatives were synthesized by introducing various substitutes into a scaffold and the antitubercular activity was evaluated. The most potent compounds 3e and 8d showed their minimum inhibitory concentrations against Mycobacterium tuberculosis as 12.5 μM. The results indicate that those compounds can be considered as leads for further development of new 1,2,4-triazole type candidates with high antitubercular activities.

AB - 1,2,4-Triazoles exert antimycobacterial activity by inhibiting the cell wall biosynthesis. In an attempt to developing lead compounds exhibiting antitubercular activities, a series of 1,2,4-triazole derivatives were synthesized by introducing various substitutes into a scaffold and the antitubercular activity was evaluated. The most potent compounds 3e and 8d showed their minimum inhibitory concentrations against Mycobacterium tuberculosis as 12.5 μM. The results indicate that those compounds can be considered as leads for further development of new 1,2,4-triazole type candidates with high antitubercular activities.

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Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives

Abstract

Bibliographical note

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UN SDGs

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