Abstract
1,2,4-Triazoles exert antimycobacterial activity by inhibiting the cell wall biosynthesis. In an attempt to developing lead compounds exhibiting antitubercular activities, a series of 1,2,4-triazole derivatives were synthesized by introducing various substitutes into a scaffold and the antitubercular activity was evaluated. The most potent compounds 3e and 8d showed their minimum inhibitory concentrations against Mycobacterium tuberculosis as 12.5 μM. The results indicate that those compounds can be considered as leads for further development of new 1,2,4-triazole type candidates with high antitubercular activities.
| Original language | English |
|---|---|
| Pages (from-to) | 43-51 |
| Number of pages | 9 |
| Journal | Bulletin of the Korean Chemical Society |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 Jan 20 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Chemistry(all)
Cite this
}
Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives. / Oh, Taegwon; Hayat, Aisal; Yoo, Euna; Cho, Sang Nae; Sheen, Yhun Yhung; Kim, Dae Kee; Choo, Hea Young Park.
In: Bulletin of the Korean Chemical Society, Vol. 36, No. 1, 20.01.2015, p. 43-51.Research output: Contribution to journal › Article
TY - JOUR
T1 - Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives
AU - Oh, Taegwon
AU - Hayat, Aisal
AU - Yoo, Euna
AU - Cho, Sang Nae
AU - Sheen, Yhun Yhung
AU - Kim, Dae Kee
AU - Choo, Hea Young Park
PY - 2015/1/20
Y1 - 2015/1/20
N2 - 1,2,4-Triazoles exert antimycobacterial activity by inhibiting the cell wall biosynthesis. In an attempt to developing lead compounds exhibiting antitubercular activities, a series of 1,2,4-triazole derivatives were synthesized by introducing various substitutes into a scaffold and the antitubercular activity was evaluated. The most potent compounds 3e and 8d showed their minimum inhibitory concentrations against Mycobacterium tuberculosis as 12.5 μM. The results indicate that those compounds can be considered as leads for further development of new 1,2,4-triazole type candidates with high antitubercular activities.
AB - 1,2,4-Triazoles exert antimycobacterial activity by inhibiting the cell wall biosynthesis. In an attempt to developing lead compounds exhibiting antitubercular activities, a series of 1,2,4-triazole derivatives were synthesized by introducing various substitutes into a scaffold and the antitubercular activity was evaluated. The most potent compounds 3e and 8d showed their minimum inhibitory concentrations against Mycobacterium tuberculosis as 12.5 μM. The results indicate that those compounds can be considered as leads for further development of new 1,2,4-triazole type candidates with high antitubercular activities.
UR - http://www.scopus.com/inward/record.url?scp=84921902947&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921902947&partnerID=8YFLogxK
U2 - 10.1002/bkcs.10009
DO - 10.1002/bkcs.10009
M3 - Article
AN - SCOPUS:84921902947
VL - 36
SP - 43
EP - 51
JO - Bulletin of the Korean Chemical Society
JF - Bulletin of the Korean Chemical Society
SN - 0253-2964
IS - 1
ER -