Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives

Taegwon Oh, Aisal Hayat, Euna Yoo, Sang Nae Cho, Yhun Yhung Sheen, Dae Kee Kim, Hea Young Park Choo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1,2,4-Triazoles exert antimycobacterial activity by inhibiting the cell wall biosynthesis. In an attempt to developing lead compounds exhibiting antitubercular activities, a series of 1,2,4-triazole derivatives were synthesized by introducing various substitutes into a scaffold and the antitubercular activity was evaluated. The most potent compounds 3e and 8d showed their minimum inhibitory concentrations against Mycobacterium tuberculosis as 12.5 μM. The results indicate that those compounds can be considered as leads for further development of new 1,2,4-triazole type candidates with high antitubercular activities.

Original languageEnglish
Pages (from-to)43-51
Number of pages9
JournalBulletin of the Korean Chemical Society
Volume36
Issue number1
DOIs
Publication statusPublished - 2015 Jan 20

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Derivatives
Lead compounds
Biosynthesis
Scaffolds
Cells
1,2,4-triazole

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Oh, Taegwon ; Hayat, Aisal ; Yoo, Euna ; Cho, Sang Nae ; Sheen, Yhun Yhung ; Kim, Dae Kee ; Choo, Hea Young Park. / Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives. In: Bulletin of the Korean Chemical Society. 2015 ; Vol. 36, No. 1. pp. 43-51.
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Antitubercular activities of the novel synthesized 1,2,4-triazole derivatives. / Oh, Taegwon; Hayat, Aisal; Yoo, Euna; Cho, Sang Nae; Sheen, Yhun Yhung; Kim, Dae Kee; Choo, Hea Young Park.

In: Bulletin of the Korean Chemical Society, Vol. 36, No. 1, 20.01.2015, p. 43-51.

Research output: Contribution to journalArticle

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