Abstract
The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.
| Original language | English |
|---|---|
| Article number | e0155784 |
| Journal | PloS one |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2016 May 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
Cite this
}
Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice. / Kwon, Bo Eun; Song, Jae Hyoung; Song, Hyuk Hwan; Kang, Ju Won; Hwang, Sam Noh; Rhee, Ki Jong; Shim, Aeri; Hong, Eun Hye; Kim, Yeon Jeong; Jeon, Sang Min; Chang, Sun Young; Kim, Dong Eun; Cho, Sungchan; Ko, Hyun Jeong.
In: PloS one, Vol. 11, No. 5, e0155784, 01.05.2016.Research output: Contribution to journal › Article
TY - JOUR
T1 - Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice
AU - Kwon, Bo Eun
AU - Song, Jae Hyoung
AU - Song, Hyuk Hwan
AU - Kang, Ju Won
AU - Hwang, Sam Noh
AU - Rhee, Ki Jong
AU - Shim, Aeri
AU - Hong, Eun Hye
AU - Kim, Yeon Jeong
AU - Jeon, Sang Min
AU - Chang, Sun Young
AU - Kim, Dong Eun
AU - Cho, Sungchan
AU - Ko, Hyun Jeong
PY - 2016/5/1
Y1 - 2016/5/1
N2 - The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.
AB - The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.
UR - http://www.scopus.com/inward/record.url?scp=84973629976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973629976&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0155784
DO - 10.1371/journal.pone.0155784
M3 - Article
C2 - 27195463
AN - SCOPUS:84973629976
VL - 11
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 5
M1 - e0155784
ER -