Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice

Bo Eun Kwon, Jae Hyoung Song, Hyuk Hwan Song, Ju Won Kang, Sam Noh Hwang, Ki Jong Rhee, Aeri Shim, Eun Hye Hong, Yeon Jeong Kim, Sang Min Jeon, Sun Young Chang, Dong Eun Kim, Sungchan Cho, Hyun Jeong Ko

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Abstract

The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.

Original languageEnglish
Article numbere0155784
JournalPloS one
Volume11
Issue number5
DOIs
Publication statusPublished - 2016 May 1

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Kwon, B. E., Song, J. H., Song, H. H., Kang, J. W., Hwang, S. N., Rhee, K. J., Shim, A., Hong, E. H., Kim, Y. J., Jeon, S. M., Chang, S. Y., Kim, D. E., Cho, S., & Ko, H. J. (2016). Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice. PloS one, 11(5), [e0155784]. https://doi.org/10.1371/journal.pone.0155784