Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice

Bo Eun Kwon, Jae Hyoung Song, Hyuk Hwan Song, Ju Won Kang, Sam Noh Hwang, Ki Jong Rhee, Aeri Shim, Eun Hye Hong, Yeon Jeong Kim, Sang Min Jeon, Sun Young Chang, Dong Eun Kim, Sungchan Cho, Hyun Jeong Ko

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.

Original languageEnglish
Article numbere0155784
JournalPloS one
Volume11
Issue number5
DOIs
Publication statusPublished - 2016 May 1

Fingerprint

Enterovirus
Viruses
Antiviral Agents
Coxsackievirus Infections
viruses
mice
pancreas
Cell death
cell death
Pancreas
Scutellaria baicalensis
infection
antiviral agents
Cell Death
tumor necrosis factors
viral load
Vero Cells
interleukin-6
lesions (animal)
blood glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kwon, Bo Eun ; Song, Jae Hyoung ; Song, Hyuk Hwan ; Kang, Ju Won ; Hwang, Sam Noh ; Rhee, Ki Jong ; Shim, Aeri ; Hong, Eun Hye ; Kim, Yeon Jeong ; Jeon, Sang Min ; Chang, Sun Young ; Kim, Dong Eun ; Cho, Sungchan ; Ko, Hyun Jeong. / Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice. In: PloS one. 2016 ; Vol. 11, No. 5.
@article{dcbb06b40ae4454bb1861bcda7472a58,
title = "Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice",
abstract = "The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.",
author = "Kwon, {Bo Eun} and Song, {Jae Hyoung} and Song, {Hyuk Hwan} and Kang, {Ju Won} and Hwang, {Sam Noh} and Rhee, {Ki Jong} and Aeri Shim and Hong, {Eun Hye} and Kim, {Yeon Jeong} and Jeon, {Sang Min} and Chang, {Sun Young} and Kim, {Dong Eun} and Sungchan Cho and Ko, {Hyun Jeong}",
year = "2016",
month = "5",
day = "1",
doi = "10.1371/journal.pone.0155784",
language = "English",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

Kwon, BE, Song, JH, Song, HH, Kang, JW, Hwang, SN, Rhee, KJ, Shim, A, Hong, EH, Kim, YJ, Jeon, SM, Chang, SY, Kim, DE, Cho, S & Ko, HJ 2016, 'Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice', PloS one, vol. 11, no. 5, e0155784. https://doi.org/10.1371/journal.pone.0155784

Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice. / Kwon, Bo Eun; Song, Jae Hyoung; Song, Hyuk Hwan; Kang, Ju Won; Hwang, Sam Noh; Rhee, Ki Jong; Shim, Aeri; Hong, Eun Hye; Kim, Yeon Jeong; Jeon, Sang Min; Chang, Sun Young; Kim, Dong Eun; Cho, Sungchan; Ko, Hyun Jeong.

In: PloS one, Vol. 11, No. 5, e0155784, 01.05.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antiviral activity of oroxylin A against coxsackievirus B3 alleviates virus-induced acute pancreatic damage in mice

AU - Kwon, Bo Eun

AU - Song, Jae Hyoung

AU - Song, Hyuk Hwan

AU - Kang, Ju Won

AU - Hwang, Sam Noh

AU - Rhee, Ki Jong

AU - Shim, Aeri

AU - Hong, Eun Hye

AU - Kim, Yeon Jeong

AU - Jeon, Sang Min

AU - Chang, Sun Young

AU - Kim, Dong Eun

AU - Cho, Sungchan

AU - Ko, Hyun Jeong

PY - 2016/5/1

Y1 - 2016/5/1

N2 - The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.

AB - The flavonoids mosloflavone, oroxylin A, and norwogonin, which were purified from Scutellaria baicalensis Georgi, significantly protected Vero cells against Coxsackievirus B3 (CVB3)-induced cell death. To investigate the in vivo antiviral activity of oroxylin A, we intraperitoneally inoculated CVB3 into 4-week-old BALB/c mice. Body weights and blood glucose levels of the mice were decreased after CVB3 infection, and these changes were attenuated by the administration of oroxylin A. Importantly, treatment of mice with oroxylin A reduced viral titers in the pancreas and decreased the serum levels of the inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α. Additionally, the administration of oroxylin A mitigated the histological pancreatic lesions and apoptotic cell death induced by CVB3 infection and increased the levels of phospho-eIF2α in infected pancreata. The results suggest that oroxylin A may represent a potent antiviral agent against CVB3 infection.

UR - http://www.scopus.com/inward/record.url?scp=84973629976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973629976&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0155784

DO - 10.1371/journal.pone.0155784

M3 - Article

C2 - 27195463

AN - SCOPUS:84973629976

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e0155784

ER -