Anxiety-Related Frontocortical Activity Is Associated With Dampened Stressor Reactivity in the Real World

Juyoen Hur; Manuel Kuhn; Shannon E. Grogans; Allegra S. Anderson; Samiha Islam; Hyung Cho Kim; Rachael M. Tillman; Andrew S. Fox; Jason F. Smith; Kathryn A. DeYoung; Alexander J. Shackman

doi:10.1177/09567976211056635

Anxiety-Related Frontocortical Activity Is Associated With Dampened Stressor Reactivity in the Real World

Juyoen Hur, Manuel Kuhn, Shannon E. Grogans, Allegra S. Anderson, Samiha Islam, Hyung Cho Kim, Rachael M. Tillman, Andrew S. Fox, Jason F. Smith, Kathryn A. DeYoung, Alexander J. Shackman

Department of Psychology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Negative affect is a fundamental dimension of human emotion. When extreme, it contributes to a variety of adverse outcomes, from physical and mental illness to divorce and premature death. Mechanistic work in animals and neuroimaging research in humans and monkeys have begun to reveal the broad contours of the neural circuits governing negative affect, but the relevance of these discoveries to everyday distress remains incompletely understood. Here, we used a combination of approaches—including neuroimaging assays of threat anticipation and emotional-face perception and more than 10,000 momentary assessments of emotional experience—to demonstrate that individuals who showed greater activation in a cingulo-opercular circuit during an anxiety-eliciting laboratory paradigm experienced lower levels of stressor-dependent distress in their daily lives (ns = 202–208 university students). Extended amygdala activation was not significantly related to momentary negative affect. These observations provide a framework for understanding the neurobiology of negative affect in the laboratory and in the real world.

Original language	English
Pages (from-to)	906-924
Number of pages	19
Journal	Psychological Science
Volume	33
Issue number	6
DOIs	https://doi.org/10.1177/09567976211056635
Publication status	Published - 2022 Jun

Bibliographical note

Funding Information:
We acknowledge assistance and critical feedback from A. Antonacci, M. Barstead, L. Friedman, J. Furcolo, M. Gamer, C. Grubb, R. Hum, C. Kaplan, T. Kashdan, J. Kuang, C. Lejuez, D. Limon, B. Nacewicz, L. Pessoa, S. Rose, J. Swayambunathan, A. Vogel, B. Winters, J. Wedlock, members of the Affective and Translational Neuroscience Laboratory, the staff of the Maryland Neuroimaging Center, and the Office of the Registrar at the University of Maryland. Processed neuroimaging data have also been shared with the Affective Neuroimaging Collaboratory (https://sites.dartmouth.edu/affectiveneuroimagingcollaboratory) and the ENIGMA Consortium Anxiety workgroup (https://enigma.ini.usc.edu/ongoing/enigma-anxiety).

Publisher Copyright:
© The Author(s) 2022.

All Science Journal Classification (ASJC) codes

Psychology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/09567976211056635

Cite this

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title = "Anxiety-Related Frontocortical Activity Is Associated With Dampened Stressor Reactivity in the Real World",

abstract = "Negative affect is a fundamental dimension of human emotion. When extreme, it contributes to a variety of adverse outcomes, from physical and mental illness to divorce and premature death. Mechanistic work in animals and neuroimaging research in humans and monkeys have begun to reveal the broad contours of the neural circuits governing negative affect, but the relevance of these discoveries to everyday distress remains incompletely understood. Here, we used a combination of approaches—including neuroimaging assays of threat anticipation and emotional-face perception and more than 10,000 momentary assessments of emotional experience—to demonstrate that individuals who showed greater activation in a cingulo-opercular circuit during an anxiety-eliciting laboratory paradigm experienced lower levels of stressor-dependent distress in their daily lives (ns = 202–208 university students). Extended amygdala activation was not significantly related to momentary negative affect. These observations provide a framework for understanding the neurobiology of negative affect in the laboratory and in the real world.",

author = "Juyoen Hur and Manuel Kuhn and Grogans, {Shannon E.} and Anderson, {Allegra S.} and Samiha Islam and Kim, {Hyung Cho} and Tillman, {Rachael M.} and Fox, {Andrew S.} and Smith, {Jason F.} and DeYoung, {Kathryn A.} and Shackman, {Alexander J.}",

note = "Funding Information: We acknowledge assistance and critical feedback from A. Antonacci, M. Barstead, L. Friedman, J. Furcolo, M. Gamer, C. Grubb, R. Hum, C. Kaplan, T. Kashdan, J. Kuang, C. Lejuez, D. Limon, B. Nacewicz, L. Pessoa, S. Rose, J. Swayambunathan, A. Vogel, B. Winters, J. Wedlock, members of the Affective and Translational Neuroscience Laboratory, the staff of the Maryland Neuroimaging Center, and the Office of the Registrar at the University of Maryland. Processed neuroimaging data have also been shared with the Affective Neuroimaging Collaboratory (https://sites.dartmouth.edu/affectiveneuroimagingcollaboratory) and the ENIGMA Consortium Anxiety workgroup (https://enigma.ini.usc.edu/ongoing/enigma-anxiety). Publisher Copyright: {\textcopyright} The Author(s) 2022.",

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AU - Anderson, Allegra S.

AU - Islam, Samiha

AU - Kim, Hyung Cho

AU - Tillman, Rachael M.

AU - Fox, Andrew S.

AU - Smith, Jason F.

AU - DeYoung, Kathryn A.

AU - Shackman, Alexander J.

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Anxiety-Related Frontocortical Activity Is Associated With Dampened Stressor Reactivity in the Real World

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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