Apicularen A, a macrolide from Chondromyces sp., inhibits growth factor induced in vitro angiogenesis

Ho Jeong Kwon, Dong Hoon Kim, Joong Sub Shim, Jong Woong Ahn

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Apicularen A (Api A) was recently isolated from Chondromyces sp. as a potent antitumor agent. Because of its unique chemical structure, a macrolide with a highly unsaturated amide side chain, and potent growth inhibitory effect in various cancer cell lines, Api A is currently in clinical trial for cancer therapy. In the present study, the effect of Api A on in vitro angiogenesis of bovine aortic endothelial cells (BAECs) was investigated. Api A potently inhibited the proliferation of BAECs in a dose-dependent manner. Treatment of the endothelial cells with up to 10 ng/ml of the compound did not show any cytotoxicity. In addition, it inhibited basic fibroblast growth factor (bFGF)-induced invasion and capillary tube formation of BAECs at concentrations of 2-5 ng/ml. These results, therefore, demonstrate that Api A is a novel antiangiogenic agent and may suppress the growth of tumors, at least in part, by the inhibition of neovascularization.

Original languageEnglish
Pages (from-to)702-705
Number of pages4
JournalJournal of microbiology and biotechnology
Volume12
Issue number4
Publication statusPublished - 2002 Aug

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

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