APOA5-1131T>C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects

Yangsoo Jang, Jey Sook Chae, Oh Yoen Kim, Hey Jun Park, Ji Young Kim, Jean Kyung Paik, Sang Hyun Lee, Jong Ho Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: We aimed to determine the influence of apolipoprotein A5 gene (APOA5)-1131. T> C single nucleotide polymorphism on the effects of dietary intervention and regular exercise (DIRE) targeting ApoA5 and triglyceride (TG) concentrations. Methods: Hypertriglyceridemia patients (TG, 150-500 mg/dL, n= 283) undertook a 12-week DIRE (replacing 1/3 of refined rice in their diets with legumes, increasing vegetable intake, and regular walking). Results: Pre-treatment, no genotype-related differences were detected in ApoA5, TG, or HDL cholesterol levels; however, post-treatment, subjects homozygous (T/. T) for the T allele had lower serum TG (P= 0.009) and higher HDL cholesterol (P= 0.036) than other subjects. In T/. T subjects, after adjustments for age, sex and weight changes (r1) or initial TG levels (r2), changes in ApoA5 levels negatively correlated with TG changes (r1. = -0.29, P= 0.05, r2. = -0.28, P< 0.1) and positively correlated with changes in HDL cholesterol (r1. = 0.30, P< 0.05, r2. = 0.32, P< 0.05) and free fatty acid (r1. = 0.38, P< 0.01, r2. = 0.40, P< 0.01). In those with moderate hypertriglyceridemia (TG, 200-500 mg/dL, n= 130), APOA5-1131. T/. T carriers achieved significantly lower TG (P= 0.007) and higher HDL cholesterol (P< 0.001) than -1131. C allele carriers. Additionally, statistically significant interactions between the -1131. T> C and the compliance of DIRE were found for the change in TG (P= 0.002) and HDL cholesterol (P= 0.039). In good compliance group, T/. T subjects showed greater reduction of TG and higher increase of HDL cholesterol than other subjects. On the other hand, non-good compliance group had no significant improvement in these variables. Conclusions: APOA5-1131. T/. T carriers may benefit more from the DIRE than C allele carriers. These effects were remarkable in patients with moderate hypertriglyceridemia and the individuals with good compliance.

Original languageEnglish
Pages (from-to)512-519
Number of pages8
JournalAtherosclerosis
Volume211
Issue number2
DOIs
Publication statusPublished - 2010 Aug 1

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Triglycerides
Genotype
Exercise
HDL Cholesterol
Genes
Hypertriglyceridemia
Alleles
Apolipoprotein A-V
Fabaceae
Vegetables
Compliance
Walking
Single Nucleotide Polymorphism
Diet
Weights and Measures
Therapeutics
Serum

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Jang, Yangsoo ; Chae, Jey Sook ; Kim, Oh Yoen ; Park, Hey Jun ; Kim, Ji Young ; Paik, Jean Kyung ; Lee, Sang Hyun ; Lee, Jong Ho. / APOA5-1131T>C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects. In: Atherosclerosis. 2010 ; Vol. 211, No. 2. pp. 512-519.
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abstract = "Objective: We aimed to determine the influence of apolipoprotein A5 gene (APOA5)-1131. T> C single nucleotide polymorphism on the effects of dietary intervention and regular exercise (DIRE) targeting ApoA5 and triglyceride (TG) concentrations. Methods: Hypertriglyceridemia patients (TG, 150-500 mg/dL, n= 283) undertook a 12-week DIRE (replacing 1/3 of refined rice in their diets with legumes, increasing vegetable intake, and regular walking). Results: Pre-treatment, no genotype-related differences were detected in ApoA5, TG, or HDL cholesterol levels; however, post-treatment, subjects homozygous (T/. T) for the T allele had lower serum TG (P= 0.009) and higher HDL cholesterol (P= 0.036) than other subjects. In T/. T subjects, after adjustments for age, sex and weight changes (r1) or initial TG levels (r2), changes in ApoA5 levels negatively correlated with TG changes (r1. = -0.29, P= 0.05, r2. = -0.28, P< 0.1) and positively correlated with changes in HDL cholesterol (r1. = 0.30, P< 0.05, r2. = 0.32, P< 0.05) and free fatty acid (r1. = 0.38, P< 0.01, r2. = 0.40, P< 0.01). In those with moderate hypertriglyceridemia (TG, 200-500 mg/dL, n= 130), APOA5-1131. T/. T carriers achieved significantly lower TG (P= 0.007) and higher HDL cholesterol (P< 0.001) than -1131. C allele carriers. Additionally, statistically significant interactions between the -1131. T> C and the compliance of DIRE were found for the change in TG (P= 0.002) and HDL cholesterol (P= 0.039). In good compliance group, T/. T subjects showed greater reduction of TG and higher increase of HDL cholesterol than other subjects. On the other hand, non-good compliance group had no significant improvement in these variables. Conclusions: APOA5-1131. T/. T carriers may benefit more from the DIRE than C allele carriers. These effects were remarkable in patients with moderate hypertriglyceridemia and the individuals with good compliance.",
author = "Yangsoo Jang and Chae, {Jey Sook} and Kim, {Oh Yoen} and Park, {Hey Jun} and Kim, {Ji Young} and Paik, {Jean Kyung} and Lee, {Sang Hyun} and Lee, {Jong Ho}",
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APOA5-1131T>C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects. / Jang, Yangsoo; Chae, Jey Sook; Kim, Oh Yoen; Park, Hey Jun; Kim, Ji Young; Paik, Jean Kyung; Lee, Sang Hyun; Lee, Jong Ho.

In: Atherosclerosis, Vol. 211, No. 2, 01.08.2010, p. 512-519.

Research output: Contribution to journalArticle

TY - JOUR

T1 - APOA5-1131T>C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects

AU - Jang, Yangsoo

AU - Chae, Jey Sook

AU - Kim, Oh Yoen

AU - Park, Hey Jun

AU - Kim, Ji Young

AU - Paik, Jean Kyung

AU - Lee, Sang Hyun

AU - Lee, Jong Ho

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Objective: We aimed to determine the influence of apolipoprotein A5 gene (APOA5)-1131. T> C single nucleotide polymorphism on the effects of dietary intervention and regular exercise (DIRE) targeting ApoA5 and triglyceride (TG) concentrations. Methods: Hypertriglyceridemia patients (TG, 150-500 mg/dL, n= 283) undertook a 12-week DIRE (replacing 1/3 of refined rice in their diets with legumes, increasing vegetable intake, and regular walking). Results: Pre-treatment, no genotype-related differences were detected in ApoA5, TG, or HDL cholesterol levels; however, post-treatment, subjects homozygous (T/. T) for the T allele had lower serum TG (P= 0.009) and higher HDL cholesterol (P= 0.036) than other subjects. In T/. T subjects, after adjustments for age, sex and weight changes (r1) or initial TG levels (r2), changes in ApoA5 levels negatively correlated with TG changes (r1. = -0.29, P= 0.05, r2. = -0.28, P< 0.1) and positively correlated with changes in HDL cholesterol (r1. = 0.30, P< 0.05, r2. = 0.32, P< 0.05) and free fatty acid (r1. = 0.38, P< 0.01, r2. = 0.40, P< 0.01). In those with moderate hypertriglyceridemia (TG, 200-500 mg/dL, n= 130), APOA5-1131. T/. T carriers achieved significantly lower TG (P= 0.007) and higher HDL cholesterol (P< 0.001) than -1131. C allele carriers. Additionally, statistically significant interactions between the -1131. T> C and the compliance of DIRE were found for the change in TG (P= 0.002) and HDL cholesterol (P= 0.039). In good compliance group, T/. T subjects showed greater reduction of TG and higher increase of HDL cholesterol than other subjects. On the other hand, non-good compliance group had no significant improvement in these variables. Conclusions: APOA5-1131. T/. T carriers may benefit more from the DIRE than C allele carriers. These effects were remarkable in patients with moderate hypertriglyceridemia and the individuals with good compliance.

AB - Objective: We aimed to determine the influence of apolipoprotein A5 gene (APOA5)-1131. T> C single nucleotide polymorphism on the effects of dietary intervention and regular exercise (DIRE) targeting ApoA5 and triglyceride (TG) concentrations. Methods: Hypertriglyceridemia patients (TG, 150-500 mg/dL, n= 283) undertook a 12-week DIRE (replacing 1/3 of refined rice in their diets with legumes, increasing vegetable intake, and regular walking). Results: Pre-treatment, no genotype-related differences were detected in ApoA5, TG, or HDL cholesterol levels; however, post-treatment, subjects homozygous (T/. T) for the T allele had lower serum TG (P= 0.009) and higher HDL cholesterol (P= 0.036) than other subjects. In T/. T subjects, after adjustments for age, sex and weight changes (r1) or initial TG levels (r2), changes in ApoA5 levels negatively correlated with TG changes (r1. = -0.29, P= 0.05, r2. = -0.28, P< 0.1) and positively correlated with changes in HDL cholesterol (r1. = 0.30, P< 0.05, r2. = 0.32, P< 0.05) and free fatty acid (r1. = 0.38, P< 0.01, r2. = 0.40, P< 0.01). In those with moderate hypertriglyceridemia (TG, 200-500 mg/dL, n= 130), APOA5-1131. T/. T carriers achieved significantly lower TG (P= 0.007) and higher HDL cholesterol (P< 0.001) than -1131. C allele carriers. Additionally, statistically significant interactions between the -1131. T> C and the compliance of DIRE were found for the change in TG (P= 0.002) and HDL cholesterol (P= 0.039). In good compliance group, T/. T subjects showed greater reduction of TG and higher increase of HDL cholesterol than other subjects. On the other hand, non-good compliance group had no significant improvement in these variables. Conclusions: APOA5-1131. T/. T carriers may benefit more from the DIRE than C allele carriers. These effects were remarkable in patients with moderate hypertriglyceridemia and the individuals with good compliance.

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