Apolipoprotein A5 gene variants are associated with decreased adiponectin levels and increased arterial stiffness in subjects with low high-density lipoprotein-cholesterol levels

Minkyung Kim, Minjoo Kim, Hye Jin Yoo, Yung Ju Bang, Sang Hyun Lee, Jong Ho Lee

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We performed a genome-wide association study to find genetic variants associated with high-density lipoprotein (HDL)-cholesterol levels in a Korean population and verified two apolipoprotein A5 (APOA5) gene variants, rs662799 (-1131T>C) and rs2075291 (c.553G>T), in 612 subjects with low HDL-cholesterol (cases) and 1536 subjects with normal HDL-cholesterol (controls). To explain this association, we compared clinical outcomes according to their genotype in normal (control) and low HDL (case) groups. In both the case and control groups, the rare alleles of rs662799 and rs2075291 were associated with higher triglyceride and lower HDL-cholesterol levels. In the subjects with the rs662799 CC genotype, lower levels of apoA-I and apoA-V and a smaller low-density lipoprotein (LDL) particle size were detected in both the case and control groups. In the case group, APOA5 rs662799 single nucleotide polymorphisms (SNPs) were associated with lower adiponectin and higher brachial-ankle pulse wave velocity (ba-PWV). Our results show that two APOA5 variants, rs662799 (-1131T>C) and rs2075291 (c.553G>T), are associated with HDL-cholesterol levels in a Korean population, and suggest that individuals with an APOA5 rs662799 CC genotype are at higher risk of atherosclerosis, particularly when they have low HDL-cholesterol, and this association is related to adiponectin levels.

Original languageEnglish
Pages (from-to)438-444
Number of pages7
JournalClinical Genetics
Volume94
Issue number5
DOIs
Publication statusPublished - 2018 Nov

Bibliographical note

Funding Information:
This study was funded by the Bio-Synergy Research Project (NRF-2012 M3A9C4048762) and the Mid-career Researcher Program (NRF-2016R1A2B4011662) of the Ministry of Science, ICT and Future Planning through the National Research Foundation, Republic of Korea. The genotype data were produced using the Korean Chip (K-CHIP) available through the K-CHIP consortium. The K-CHIP was designed by the Center for Genome Science, Korea National Institute of Health, Korea (4845-301, 3000-3031).

Publisher Copyright:
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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