Apoptotic effect of macrophages against Mycobacterium tuberculosis

Lee Han Kim, SungJae Shin

Research output: Contribution to journalReview article

Abstract

Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage cell death, a common outcome during Mtb infection, may initiate host- or pathogen-favored immune responses, resulting in facilitating protection or pathogenesis, respectively. In addition, virulent Mtb strains are known to inhibit apoptosis and consequently down-regulates immune response using a variety of strategies. In many recent studies have shown that virulent Mtb can either augment or reduce apoptosis by regulating expression of pro-apoptotic and anti-apoptotic proteins belonging to Bcl-2 family proteins. In this review, we will discuss and dissect the apoptotic pathways of Bcl-2 family proteins in Mtb-infected macrophages.

Original languageEnglish
Pages (from-to)312-318
Number of pages7
JournalJournal of Bacteriology and Virology
Volume46
Issue number4
DOIs
Publication statusPublished - 2016 Dec 1

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Mycobacterium tuberculosis
Macrophages
Mycobacterium Infections
Apoptosis
Apoptosis Regulatory Proteins
Alveolar Macrophages
Aerosols
Inhalation
Tuberculosis
Proteins
Cell Death
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

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title = "Apoptotic effect of macrophages against Mycobacterium tuberculosis",
abstract = "Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage cell death, a common outcome during Mtb infection, may initiate host- or pathogen-favored immune responses, resulting in facilitating protection or pathogenesis, respectively. In addition, virulent Mtb strains are known to inhibit apoptosis and consequently down-regulates immune response using a variety of strategies. In many recent studies have shown that virulent Mtb can either augment or reduce apoptosis by regulating expression of pro-apoptotic and anti-apoptotic proteins belonging to Bcl-2 family proteins. In this review, we will discuss and dissect the apoptotic pathways of Bcl-2 family proteins in Mtb-infected macrophages.",
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Apoptotic effect of macrophages against Mycobacterium tuberculosis. / Kim, Lee Han; Shin, SungJae.

In: Journal of Bacteriology and Virology, Vol. 46, No. 4, 01.12.2016, p. 312-318.

Research output: Contribution to journalReview article

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