Abstract
Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage cell death, a common outcome during Mtb infection, may initiate host- or pathogen-favored immune responses, resulting in facilitating protection or pathogenesis, respectively. In addition, virulent Mtb strains are known to inhibit apoptosis and consequently down-regulates immune response using a variety of strategies. In many recent studies have shown that virulent Mtb can either augment or reduce apoptosis by regulating expression of pro-apoptotic and anti-apoptotic proteins belonging to Bcl-2 family proteins. In this review, we will discuss and dissect the apoptotic pathways of Bcl-2 family proteins in Mtb-infected macrophages.
| Original language | English |
|---|---|
| Pages (from-to) | 312-318 |
| Number of pages | 7 |
| Journal | Journal of Bacteriology and Virology |
| Volume | 46 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2016 Dec |
Bibliographical note
Funding Information:This study was supported by the Basic Science Research Program and the International Research & Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning of Korea (NRF-2016R1A2A1A05005263 and NRF-2014K1A3A7A03075054).
Publisher Copyright:
© 2016, Chonnam National University Medical School. All rights reserved.
All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Virology
