Apoptotic effect of macrophages against Mycobacterium tuberculosis

Lee Han Kim, Sung Jae Shin

Research output: Contribution to journalReview articlepeer-review

Abstract

Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage cell death, a common outcome during Mtb infection, may initiate host- or pathogen-favored immune responses, resulting in facilitating protection or pathogenesis, respectively. In addition, virulent Mtb strains are known to inhibit apoptosis and consequently down-regulates immune response using a variety of strategies. In many recent studies have shown that virulent Mtb can either augment or reduce apoptosis by regulating expression of pro-apoptotic and anti-apoptotic proteins belonging to Bcl-2 family proteins. In this review, we will discuss and dissect the apoptotic pathways of Bcl-2 family proteins in Mtb-infected macrophages.

Original languageEnglish
Pages (from-to)312-318
Number of pages7
JournalJournal of Bacteriology and Virology
Volume46
Issue number4
DOIs
Publication statusPublished - 2016 Dec

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program and the International Research & Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning of Korea (NRF-2016R1A2A1A05005263 and NRF-2014K1A3A7A03075054).

Publisher Copyright:
© 2016, Chonnam National University Medical School. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

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