Application of a novel diagnostic rule in the differential diagnosis between acute gouty arthritis and septic arthritis

Kwang Hoon Lee, Sang Tae Choi, Soo Kyung Lee, Joo Hyun Lee, Bo Young Yoon

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Septic arthritis and gout are major diseases that should be suspected in patients with acute monoarthritis. These two diseases are clinically similar and often indistinguishable without the help of synovial fluid analysis. Recently, a novel diagnostic rule for gout without synovial fluid analysis was developed and showed relevant performances. This study aimed to determine whether this diagnostic rule could perform well in distinguishing gout from septic arthritis. The diagnostic rule comprises 7 clinical and laboratory variables, each of which is given a specified score. The probability of gout is classified into 3 groups according to the sum of the scores: high (= 8), intermediate (> 4 to < 8) and low probability (= 4). In this retrospective study, we applied this diagnostic rule to 136 patients who presented as acute monoarthritis and were subsequently diagnosed as acute gout (n = 82) and septic arthritis (n = 54) based on synovial fluid analysis. The mean sum of scores of acute gout patients was significantly higher than that of those with septic arthritis (8.6 ± 0.2 vs. 3.6 ± 0.32, P < 0.001). Patients with acute gout had significantly more 'high', and less 'low' probabilities compared to those with septic arthritis (Eta[η]: 0.776). The prevalence of acute gouty arthritis, as confirmed by the presence of monosodium crystal, was 95.5% (61/64), 57.5% (19/33), and 5.1% (2/39) in high, intermediate and low probability group, respectively. The recently introduced diagnostic rule properly discriminates acute gout from septic arthritis. It may help physicians diagnose gout in cases difficult to be differentiated from septic arthritis.

Original languageEnglish
Pages (from-to)700-704
Number of pages5
JournalJournal of Korean medical science
Volume30
Issue number6
DOIs
Publication statusPublished - 2015 Jan 1

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Gouty Arthritis
Infectious Arthritis
Gout
Differential Diagnosis
Synovial Fluid
Retrospective Studies
Physicians

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Kwang Hoon ; Choi, Sang Tae ; Lee, Soo Kyung ; Lee, Joo Hyun ; Yoon, Bo Young. / Application of a novel diagnostic rule in the differential diagnosis between acute gouty arthritis and septic arthritis. In: Journal of Korean medical science. 2015 ; Vol. 30, No. 6. pp. 700-704.
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abstract = "Septic arthritis and gout are major diseases that should be suspected in patients with acute monoarthritis. These two diseases are clinically similar and often indistinguishable without the help of synovial fluid analysis. Recently, a novel diagnostic rule for gout without synovial fluid analysis was developed and showed relevant performances. This study aimed to determine whether this diagnostic rule could perform well in distinguishing gout from septic arthritis. The diagnostic rule comprises 7 clinical and laboratory variables, each of which is given a specified score. The probability of gout is classified into 3 groups according to the sum of the scores: high (= 8), intermediate (> 4 to < 8) and low probability (= 4). In this retrospective study, we applied this diagnostic rule to 136 patients who presented as acute monoarthritis and were subsequently diagnosed as acute gout (n = 82) and septic arthritis (n = 54) based on synovial fluid analysis. The mean sum of scores of acute gout patients was significantly higher than that of those with septic arthritis (8.6 ± 0.2 vs. 3.6 ± 0.32, P < 0.001). Patients with acute gout had significantly more 'high', and less 'low' probabilities compared to those with septic arthritis (Eta[η]: 0.776). The prevalence of acute gouty arthritis, as confirmed by the presence of monosodium crystal, was 95.5{\%} (61/64), 57.5{\%} (19/33), and 5.1{\%} (2/39) in high, intermediate and low probability group, respectively. The recently introduced diagnostic rule properly discriminates acute gout from septic arthritis. It may help physicians diagnose gout in cases difficult to be differentiated from septic arthritis.",
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Application of a novel diagnostic rule in the differential diagnosis between acute gouty arthritis and septic arthritis. / Lee, Kwang Hoon; Choi, Sang Tae; Lee, Soo Kyung; Lee, Joo Hyun; Yoon, Bo Young.

In: Journal of Korean medical science, Vol. 30, No. 6, 01.01.2015, p. 700-704.

Research output: Contribution to journalArticle

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