Application of Cl3CCONH2/PPh3 towards the synthesis of bioactive amides

Skydow Chaysripongkul, Wanchai Pluempanupat, Doo Ok Jang, Warinthorn Chavasiri

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cl3CCONH2 coupled with PPh3 was determined to be an effective reagent for the conversion of carboxylic acids to their corresponding acid chlorides. Subsequently, these acid chlorides were successfully trapped with amines in the presence of 4-picoline, yielding amides. This practical and efficient protocol can be utilized for the synthesis of biological amides in excellent yields.

Original languageEnglish
Pages (from-to)2066-2070
Number of pages5
JournalBulletin of the Korean Chemical Society
Volume30
Issue number9
DOIs
Publication statusPublished - 2009 Sep 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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