Application of Cl3CCONH2/PPh3 towards the synthesis of bioactive amides

Skydow Chaysripongkul; Wanchai Pluempanupat; Doo Ok Jang; Warinthorn Chavasiri

doi:10.5012/bkcs.2009.30.9.2066

Application of Cl₃CCONH₂/PPh₃ towards the synthesis of bioactive amides

Skydow Chaysripongkul, Wanchai Pluempanupat, Doo Ok Jang, Warinthorn Chavasiri

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

Cl₃CCONH₂ coupled with PPh₃ was determined to be an effective reagent for the conversion of carboxylic acids to their corresponding acid chlorides. Subsequently, these acid chlorides were successfully trapped with amines in the presence of 4-picoline, yielding amides. This practical and efficient protocol can be utilized for the synthesis of biological amides in excellent yields.

Original language	English
Pages (from-to)	2066-2070
Number of pages	5
Journal	Bulletin of the Korean Chemical Society
Volume	30
Issue number	9
DOIs	https://doi.org/10.5012/bkcs.2009.30.9.2066
Publication status	Published - 2009 Sep 1

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All Science Journal Classification (ASJC) codes

Chemistry(all)

Cite this

Chaysripongkul, S., Pluempanupat, W., Jang, D. O., & Chavasiri, W. (2009). Application of Cl₃CCONH₂/PPh₃ towards the synthesis of bioactive amides. Bulletin of the Korean Chemical Society, 30(9), 2066-2070. https://doi.org/10.5012/bkcs.2009.30.9.2066

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10.5012/bkcs.2009.30.9.2066