Application of nanomaterials as an advanced strategy for the diagnosis, prevention, and treatment of viral diseases

Jong Woo Lim, Yu Rim Ahn, Geunseon Park, Hyun Ouk Kim, Seungjoo Haam

Research output: Contribution to journalReview articlepeer-review

Abstract

The coronavirus disease (COVID-19) pandemic poses serious global health concerns with the continued emergence of new variants. The periodic outbreak of novel emerging and re-emerging infectious pathogens has elevated concerns and challenges for the future. To develop mitigation strategies against infectious diseases, nano-based approaches are being increasingly applied in diagnostic systems, prophylactic vaccines, and therapeutics. This review presents the properties of various nanoplatforms and discusses their role in the development of sensors, vectors, delivery agents, intrinsic immunostimulants, and viral inhibitors. Advanced nanomedical applications for infectious diseases have been highlighted. Moreover, physicochemical properties that confer physiological advantages and contribute to the control and inhibition of infectious diseases have been discussed. Safety concerns limit the commercial production and clinical use of these technologies in humans; however, overcoming these limitations may enable the use of nanomaterials to resolve current infection control issues via application of nanomaterials as a platform for the diagnosis, prevention, and treatment of viral diseases.

Original languageEnglish
Article number1570
JournalPharmaceutics
Volume13
Issue number10
DOIs
Publication statusPublished - 2021 Oct

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF-2019R1I1A1 A01057005, NRF-2018M3A9E2022819, NRF-2021M3E5E3083400, and NRF-2021M3E5E3080565).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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