Abstract
Erythema induratum of Bazin is a chronic, nodular subcutaneous eruption usually occurring on the lower legs of young women. Erythema induratum of Bazin hasbeen regarded as a tuberculide, a hypersensitivity response to Mycobacterium tuberculosis. The pathogenesis of erythema induratum of Bazin associated with tuberculosis is still debatable because mycobacteria cannot be cultured from the skin lesions. QuantiFERON®-TB Gold test detects INF- γ released by T cells in response to Mycobacterium tuberculosis-specific antigens, which offers an improved diagnostic test of latent tuberculosis infection. We experienced two cases of erythema induratum of Bazin, which showed normal chest X-ray and negative TB-PCR. However the QuantiFERON -TB Gold test was positive which led us to a diagnosis of latent tuberculosis infection. Both patients were treated with anti-tuberculosis medications, which was followed by successful resolution of the skin lesions. Therefore, we report the application of the QuantiFERON®-TB Gold test for the confirmation of latent tuberculosis infection in erythema induratum of Bazin patients.
| Original language | English |
|---|---|
| Pages (from-to) | 850-854 |
| Number of pages | 5 |
| Journal | Korean Journal of Dermatology |
| Volume | 47 |
| Issue number | 7 |
| Publication status | Published - 2009 Jul 1 |
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All Science Journal Classification (ASJC) codes
- Dermatology
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Application of the QuantiFERON® -TB gold test in two cases of Erythema Induratum of Bazin. / Ji, Jae Hong; Park, Hwa Young; Lee, Yoon Hee; Lee, Hae Jin; Choi, Eung Ho.
In: Korean Journal of Dermatology, Vol. 47, No. 7, 01.07.2009, p. 850-854.Research output: Contribution to journal › Article
TY - JOUR
T1 - Application of the QuantiFERON® -TB gold test in two cases of Erythema Induratum of Bazin
AU - Ji, Jae Hong
AU - Park, Hwa Young
AU - Lee, Yoon Hee
AU - Lee, Hae Jin
AU - Choi, Eung Ho
PY - 2009/7/1
Y1 - 2009/7/1
N2 - Erythema induratum of Bazin is a chronic, nodular subcutaneous eruption usually occurring on the lower legs of young women. Erythema induratum of Bazin hasbeen regarded as a tuberculide, a hypersensitivity response to Mycobacterium tuberculosis. The pathogenesis of erythema induratum of Bazin associated with tuberculosis is still debatable because mycobacteria cannot be cultured from the skin lesions. QuantiFERON®-TB Gold test detects INF- γ released by T cells in response to Mycobacterium tuberculosis-specific antigens, which offers an improved diagnostic test of latent tuberculosis infection. We experienced two cases of erythema induratum of Bazin, which showed normal chest X-ray and negative TB-PCR. However the QuantiFERON -TB Gold test was positive which led us to a diagnosis of latent tuberculosis infection. Both patients were treated with anti-tuberculosis medications, which was followed by successful resolution of the skin lesions. Therefore, we report the application of the QuantiFERON®-TB Gold test for the confirmation of latent tuberculosis infection in erythema induratum of Bazin patients.
AB - Erythema induratum of Bazin is a chronic, nodular subcutaneous eruption usually occurring on the lower legs of young women. Erythema induratum of Bazin hasbeen regarded as a tuberculide, a hypersensitivity response to Mycobacterium tuberculosis. The pathogenesis of erythema induratum of Bazin associated with tuberculosis is still debatable because mycobacteria cannot be cultured from the skin lesions. QuantiFERON®-TB Gold test detects INF- γ released by T cells in response to Mycobacterium tuberculosis-specific antigens, which offers an improved diagnostic test of latent tuberculosis infection. We experienced two cases of erythema induratum of Bazin, which showed normal chest X-ray and negative TB-PCR. However the QuantiFERON -TB Gold test was positive which led us to a diagnosis of latent tuberculosis infection. Both patients were treated with anti-tuberculosis medications, which was followed by successful resolution of the skin lesions. Therefore, we report the application of the QuantiFERON®-TB Gold test for the confirmation of latent tuberculosis infection in erythema induratum of Bazin patients.
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M3 - Article
VL - 47
SP - 850
EP - 854
JO - Korean Journal of Dermatology
JF - Korean Journal of Dermatology
SN - 0494-4739
IS - 7
ER -