Application of the QuantiFERON® -TB gold test in two cases of Erythema Induratum of Bazin

Jae Hong Ji, Hwa Young Park, Yoon Hee Lee, Hae Jin Lee, Eung Ho Choi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Erythema induratum of Bazin is a chronic, nodular subcutaneous eruption usually occurring on the lower legs of young women. Erythema induratum of Bazin hasbeen regarded as a tuberculide, a hypersensitivity response to Mycobacterium tuberculosis. The pathogenesis of erythema induratum of Bazin associated with tuberculosis is still debatable because mycobacteria cannot be cultured from the skin lesions. QuantiFERON®-TB Gold test detects INF- γ released by T cells in response to Mycobacterium tuberculosis-specific antigens, which offers an improved diagnostic test of latent tuberculosis infection. We experienced two cases of erythema induratum of Bazin, which showed normal chest X-ray and negative TB-PCR. However the QuantiFERON -TB Gold test was positive which led us to a diagnosis of latent tuberculosis infection. Both patients were treated with anti-tuberculosis medications, which was followed by successful resolution of the skin lesions. Therefore, we report the application of the QuantiFERON®-TB Gold test for the confirmation of latent tuberculosis infection in erythema induratum of Bazin patients.

Original languageEnglish
Pages (from-to)850-854
Number of pages5
JournalKorean Journal of Dermatology
Volume47
Issue number7
Publication statusPublished - 2009 Jul 1

Fingerprint

Erythema Induratum
Gold
Latent Tuberculosis
Tuberculosis
cutaneous Tuberculosis
Skin
Mycobacterium
Mycobacterium tuberculosis
Routine Diagnostic Tests
Leg
Hypersensitivity
Thorax
X-Rays
T-Lymphocytes
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Ji, Jae Hong ; Park, Hwa Young ; Lee, Yoon Hee ; Lee, Hae Jin ; Choi, Eung Ho. / Application of the QuantiFERON® -TB gold test in two cases of Erythema Induratum of Bazin. In: Korean Journal of Dermatology. 2009 ; Vol. 47, No. 7. pp. 850-854.
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abstract = "Erythema induratum of Bazin is a chronic, nodular subcutaneous eruption usually occurring on the lower legs of young women. Erythema induratum of Bazin hasbeen regarded as a tuberculide, a hypersensitivity response to Mycobacterium tuberculosis. The pathogenesis of erythema induratum of Bazin associated with tuberculosis is still debatable because mycobacteria cannot be cultured from the skin lesions. QuantiFERON{\circledR}-TB Gold test detects INF- γ released by T cells in response to Mycobacterium tuberculosis-specific antigens, which offers an improved diagnostic test of latent tuberculosis infection. We experienced two cases of erythema induratum of Bazin, which showed normal chest X-ray and negative TB-PCR. However the QuantiFERON -TB Gold test was positive which led us to a diagnosis of latent tuberculosis infection. Both patients were treated with anti-tuberculosis medications, which was followed by successful resolution of the skin lesions. Therefore, we report the application of the QuantiFERON{\circledR}-TB Gold test for the confirmation of latent tuberculosis infection in erythema induratum of Bazin patients.",
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Application of the QuantiFERON® -TB gold test in two cases of Erythema Induratum of Bazin. / Ji, Jae Hong; Park, Hwa Young; Lee, Yoon Hee; Lee, Hae Jin; Choi, Eung Ho.

In: Korean Journal of Dermatology, Vol. 47, No. 7, 01.07.2009, p. 850-854.

Research output: Contribution to journalArticle

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