Application of topical acids improves atopic dermatitis in murine model by enhancement of skin barrier functions regardless of the origin of acids

Noo Ri Lee, Hae Jin Lee, Na Young Yoon, Donghye Kim, Minyoung Jung, Eung Ho Choi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The acidic pH of the stratum corneum (SC) is important for epidermal permeability barrier homeostasis. Acidification of the skin surface has been suggested as a therapeutic strategy for skin disorders such as atopic dermatitis (AD). Objective: We performed an animal study to evaluate the usefulness of acidification of SC for inhibition of AD lesions and to find out if the therapeutic effect of vinegar is attributable to its herbal contents, rather than its acidity. Methods: Five groups of six oxazolone-Treated (Ox)-AD mice were treated for three weeks with creams of different acidity: vehicle cream alone (pH 5.5), neutralized vinegar cream (pH 7.4), pH 5.0 vinegar cream, pH 3.5 vinegar cream, and pH 3.5 hydrogen chloride (HCl) cream. Also, we have compared two groups of Ox-AD mice treated with pH 5.5 vehicle cream or pH 5.5 vinegar cream. Results: Ox-AD mice treated with acidic creams exhibited fewer AD-like lesions, had significantly lower eczema scores, decreased basal by transepidermal water loss (TEWL), and increased SC hydration compared to the groups given only vehicle and neutral cream. There was no significant difference between the acidic vinegar and HCl groups. Between the groups treated with vehicle and pH 5.5 vinegar cream, there was no difference in eczema score, basal TEWL and SC hydration. Conclusion: Application of topical acids, regardless of their source materials, inhibits the development of AD lesions by maintenance of skin surface pH and skin barrier function in murine model.

Original languageEnglish
Pages (from-to)690-696
Number of pages7
JournalAnnals of Dermatology
Volume28
Issue number6
DOIs
Publication statusPublished - 2016 Dec

Fingerprint

Atopic Dermatitis
Acetic Acid
Skin
Acids
Oxazolone
Cornea
Hydrochloric Acid
Eczema
Water
Therapeutic Uses
Permeability
Homeostasis
Maintenance

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Lee, Noo Ri ; Lee, Hae Jin ; Yoon, Na Young ; Kim, Donghye ; Jung, Minyoung ; Choi, Eung Ho. / Application of topical acids improves atopic dermatitis in murine model by enhancement of skin barrier functions regardless of the origin of acids. In: Annals of Dermatology. 2016 ; Vol. 28, No. 6. pp. 690-696.
@article{b71ce95d33a24482bc7a36afbd854508,
title = "Application of topical acids improves atopic dermatitis in murine model by enhancement of skin barrier functions regardless of the origin of acids",
abstract = "Background: The acidic pH of the stratum corneum (SC) is important for epidermal permeability barrier homeostasis. Acidification of the skin surface has been suggested as a therapeutic strategy for skin disorders such as atopic dermatitis (AD). Objective: We performed an animal study to evaluate the usefulness of acidification of SC for inhibition of AD lesions and to find out if the therapeutic effect of vinegar is attributable to its herbal contents, rather than its acidity. Methods: Five groups of six oxazolone-Treated (Ox)-AD mice were treated for three weeks with creams of different acidity: vehicle cream alone (pH 5.5), neutralized vinegar cream (pH 7.4), pH 5.0 vinegar cream, pH 3.5 vinegar cream, and pH 3.5 hydrogen chloride (HCl) cream. Also, we have compared two groups of Ox-AD mice treated with pH 5.5 vehicle cream or pH 5.5 vinegar cream. Results: Ox-AD mice treated with acidic creams exhibited fewer AD-like lesions, had significantly lower eczema scores, decreased basal by transepidermal water loss (TEWL), and increased SC hydration compared to the groups given only vehicle and neutral cream. There was no significant difference between the acidic vinegar and HCl groups. Between the groups treated with vehicle and pH 5.5 vinegar cream, there was no difference in eczema score, basal TEWL and SC hydration. Conclusion: Application of topical acids, regardless of their source materials, inhibits the development of AD lesions by maintenance of skin surface pH and skin barrier function in murine model.",
author = "Lee, {Noo Ri} and Lee, {Hae Jin} and Yoon, {Na Young} and Donghye Kim and Minyoung Jung and Choi, {Eung Ho}",
year = "2016",
month = "12",
doi = "10.5021/ad.2016.28.6.690",
language = "English",
volume = "28",
pages = "690--696",
journal = "Annals of Dermatology",
issn = "1013-9087",
publisher = "Korean Dermatological Association",
number = "6",

}

Application of topical acids improves atopic dermatitis in murine model by enhancement of skin barrier functions regardless of the origin of acids. / Lee, Noo Ri; Lee, Hae Jin; Yoon, Na Young; Kim, Donghye; Jung, Minyoung; Choi, Eung Ho.

In: Annals of Dermatology, Vol. 28, No. 6, 12.2016, p. 690-696.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Application of topical acids improves atopic dermatitis in murine model by enhancement of skin barrier functions regardless of the origin of acids

AU - Lee, Noo Ri

AU - Lee, Hae Jin

AU - Yoon, Na Young

AU - Kim, Donghye

AU - Jung, Minyoung

AU - Choi, Eung Ho

PY - 2016/12

Y1 - 2016/12

N2 - Background: The acidic pH of the stratum corneum (SC) is important for epidermal permeability barrier homeostasis. Acidification of the skin surface has been suggested as a therapeutic strategy for skin disorders such as atopic dermatitis (AD). Objective: We performed an animal study to evaluate the usefulness of acidification of SC for inhibition of AD lesions and to find out if the therapeutic effect of vinegar is attributable to its herbal contents, rather than its acidity. Methods: Five groups of six oxazolone-Treated (Ox)-AD mice were treated for three weeks with creams of different acidity: vehicle cream alone (pH 5.5), neutralized vinegar cream (pH 7.4), pH 5.0 vinegar cream, pH 3.5 vinegar cream, and pH 3.5 hydrogen chloride (HCl) cream. Also, we have compared two groups of Ox-AD mice treated with pH 5.5 vehicle cream or pH 5.5 vinegar cream. Results: Ox-AD mice treated with acidic creams exhibited fewer AD-like lesions, had significantly lower eczema scores, decreased basal by transepidermal water loss (TEWL), and increased SC hydration compared to the groups given only vehicle and neutral cream. There was no significant difference between the acidic vinegar and HCl groups. Between the groups treated with vehicle and pH 5.5 vinegar cream, there was no difference in eczema score, basal TEWL and SC hydration. Conclusion: Application of topical acids, regardless of their source materials, inhibits the development of AD lesions by maintenance of skin surface pH and skin barrier function in murine model.

AB - Background: The acidic pH of the stratum corneum (SC) is important for epidermal permeability barrier homeostasis. Acidification of the skin surface has been suggested as a therapeutic strategy for skin disorders such as atopic dermatitis (AD). Objective: We performed an animal study to evaluate the usefulness of acidification of SC for inhibition of AD lesions and to find out if the therapeutic effect of vinegar is attributable to its herbal contents, rather than its acidity. Methods: Five groups of six oxazolone-Treated (Ox)-AD mice were treated for three weeks with creams of different acidity: vehicle cream alone (pH 5.5), neutralized vinegar cream (pH 7.4), pH 5.0 vinegar cream, pH 3.5 vinegar cream, and pH 3.5 hydrogen chloride (HCl) cream. Also, we have compared two groups of Ox-AD mice treated with pH 5.5 vehicle cream or pH 5.5 vinegar cream. Results: Ox-AD mice treated with acidic creams exhibited fewer AD-like lesions, had significantly lower eczema scores, decreased basal by transepidermal water loss (TEWL), and increased SC hydration compared to the groups given only vehicle and neutral cream. There was no significant difference between the acidic vinegar and HCl groups. Between the groups treated with vehicle and pH 5.5 vinegar cream, there was no difference in eczema score, basal TEWL and SC hydration. Conclusion: Application of topical acids, regardless of their source materials, inhibits the development of AD lesions by maintenance of skin surface pH and skin barrier function in murine model.

UR - http://www.scopus.com/inward/record.url?scp=85000428290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85000428290&partnerID=8YFLogxK

U2 - 10.5021/ad.2016.28.6.690

DO - 10.5021/ad.2016.28.6.690

M3 - Article

AN - SCOPUS:85000428290

VL - 28

SP - 690

EP - 696

JO - Annals of Dermatology

JF - Annals of Dermatology

SN - 1013-9087

IS - 6

ER -