Applying the bacterial meningitis score in children with cerebrospinal fluid pleocytosis: A single center’s experience

Jungpyo Lee, Hyeeun Kwon, Joon Soo Lee, Heung Dong Kim, Hoon Chul Kang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: The widespread introduction of bacterial conjugate vaccines has decreased the risk of cerebrospinal fluid (CSF) pleocytosis due to bacterial meningitis (BM) in children. However, most patients with CSF pleocytosis are hospitalized and treated with parenteral antibiotics for several days. The bacterial meningitis score (BMS) is a validated multivariate model derived from a pediatric population in the postconjugate vaccine era and has been evaluated in several studies. In the present study, we examined the usefulness of BMS in South Korean patients. Methods: This study included 1,063 patients with CSF pleocytosis aged between 2 months and 18 years. The BMS was calculated for all patients, and the sensitivity and negative predictive value (NPV) of the test were evaluated. Results: Of 1,063 patients, 1,059 (99.6%) had aseptic meningitis (AM). Only four patients (0.4%) had BM. The majority of patients (98%) had a BMS of =1, indicating a diagnosis of AM. The BMS was 0 in 635 patients (60%) and 1 in 405 patients (38%). All four BM patients had a BMS of =4. Conclusion: To our knowledge, this is the first study to investigate the diagnostic strength of the BMS in South Korea. In our study, the BMS showed 100% sensitivity and 100% NPV. Therefore, we believe that the BMS is a good clinical prediction rule to identify children with CSF pleocytosis who are at a risk of BM.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalKorean Journal of Pediatrics
Volume58
Issue number7
DOIs
Publication statusPublished - 2015 Jul 15

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Bacterial Meningitides
Leukocytosis
Cerebrospinal Fluid
Aseptic Meningitis
Bacterial Vaccines
Predictive Value of Tests
Conjugate Vaccines
Republic of Korea
Decision Support Techniques
Vaccines

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

Cite this

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title = "Applying the bacterial meningitis score in children with cerebrospinal fluid pleocytosis: A single center’s experience",
abstract = "Purpose: The widespread introduction of bacterial conjugate vaccines has decreased the risk of cerebrospinal fluid (CSF) pleocytosis due to bacterial meningitis (BM) in children. However, most patients with CSF pleocytosis are hospitalized and treated with parenteral antibiotics for several days. The bacterial meningitis score (BMS) is a validated multivariate model derived from a pediatric population in the postconjugate vaccine era and has been evaluated in several studies. In the present study, we examined the usefulness of BMS in South Korean patients. Methods: This study included 1,063 patients with CSF pleocytosis aged between 2 months and 18 years. The BMS was calculated for all patients, and the sensitivity and negative predictive value (NPV) of the test were evaluated. Results: Of 1,063 patients, 1,059 (99.6{\%}) had aseptic meningitis (AM). Only four patients (0.4{\%}) had BM. The majority of patients (98{\%}) had a BMS of =1, indicating a diagnosis of AM. The BMS was 0 in 635 patients (60{\%}) and 1 in 405 patients (38{\%}). All four BM patients had a BMS of =4. Conclusion: To our knowledge, this is the first study to investigate the diagnostic strength of the BMS in South Korea. In our study, the BMS showed 100{\%} sensitivity and 100{\%} NPV. Therefore, we believe that the BMS is a good clinical prediction rule to identify children with CSF pleocytosis who are at a risk of BM.",
author = "Jungpyo Lee and Hyeeun Kwon and Lee, {Joon Soo} and Kim, {Heung Dong} and Kang, {Hoon Chul}",
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Applying the bacterial meningitis score in children with cerebrospinal fluid pleocytosis : A single center’s experience. / Lee, Jungpyo; Kwon, Hyeeun; Lee, Joon Soo; Kim, Heung Dong; Kang, Hoon Chul.

In: Korean Journal of Pediatrics, Vol. 58, No. 7, 15.07.2015, p. 251-255.

Research output: Contribution to journalArticle

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AU - Lee, Jungpyo

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AU - Lee, Joon Soo

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AB - Purpose: The widespread introduction of bacterial conjugate vaccines has decreased the risk of cerebrospinal fluid (CSF) pleocytosis due to bacterial meningitis (BM) in children. However, most patients with CSF pleocytosis are hospitalized and treated with parenteral antibiotics for several days. The bacterial meningitis score (BMS) is a validated multivariate model derived from a pediatric population in the postconjugate vaccine era and has been evaluated in several studies. In the present study, we examined the usefulness of BMS in South Korean patients. Methods: This study included 1,063 patients with CSF pleocytosis aged between 2 months and 18 years. The BMS was calculated for all patients, and the sensitivity and negative predictive value (NPV) of the test were evaluated. Results: Of 1,063 patients, 1,059 (99.6%) had aseptic meningitis (AM). Only four patients (0.4%) had BM. The majority of patients (98%) had a BMS of =1, indicating a diagnosis of AM. The BMS was 0 in 635 patients (60%) and 1 in 405 patients (38%). All four BM patients had a BMS of =4. Conclusion: To our knowledge, this is the first study to investigate the diagnostic strength of the BMS in South Korea. In our study, the BMS showed 100% sensitivity and 100% NPV. Therefore, we believe that the BMS is a good clinical prediction rule to identify children with CSF pleocytosis who are at a risk of BM.

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