Approaches for Regenerative Healing of Cutaneous Wound with an Emphasis on Strategies Activating the Wnt/β-Catenin Pathway

Sehee Choi, Minguen Yoon, Kang Yell Choi

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)


Significance: In adult mammals, spontaneous repair of a cutaneous wound occurs slowly and leaves a scar with skin adnexa deficiencies. To accelerate cutaneous wound-healing rates and avoid scar formation, current studies have focused on regenerative therapies. Recent Advances: Emerging therapeutics for regenerative wound healing often focus on the use of growth factors and stem cells. However, these therapeutic approaches have limited routine clinical use due to high costs and technical requirements. Critical Issue: Understanding the molecular mechanisms involved in the signaling pathways for cutaneous wound healing and neogenic synthesis of the skin components is important for identification of novel targets for the development of regenerative wound-healing agents. Future Directions: The Wnt/β-catenin pathway is a well-known key player for enhancement of the overall healing process involving tissue regeneration via crosstalk with other signaling pathways. Strategies that activate the Wnt/β-catenin pathway via modulation of the pathway-controlling regulatory factors could provide effective therapeutic approaches for regenerative wound healing.

Original languageEnglish
Pages (from-to)70-86
Number of pages17
JournalAdvances in Wound Care
Issue number2
Publication statusPublished - 2022 Feb 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation (NRF) of Korea grant funded by the Korean Government (MSIP) (2019R1A2C3002 751, 2020M3E5E2040018). M.Y. was supported by a BK21 PLUS program.

Publisher Copyright:
© Sehee Choi et al., 2022; Published by Mary Ann Liebert, Inc. 2022.

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine


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