Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin αvβ3 via magnetic resonance imaging

Eun Kyung Lim, Bongjune Kim, Yuna Choi, Youngjun Ro, Eun Jin Cho, Jung Hwan Lee, Sung Ho Ryu, Jinsuck Suh, Seungjoo Haam, yongmin Huh

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An understanding of neovascularization and/or angiogenesis in cancer is acutely required for effective cancer therapy due to concerns about tumor growth and metastasis. In particular, integrin αvβ3 is closely associated with cell migration and invasion during angiogenesis. Hence, we developed aptamer αvβ3 -conjugated magnetic nanoparticles (Apt αvβ3 -MNPs) to enable precise detection of integrin-expressing cancer cells using magnetic resonance imaging. Apt αvβ3 -MNPs exhibited not only cytocompatibility, but also an efficient targeting ability with high magnetic sensitivity through in vitro/in vivo studies. The results of this study demonstrate that Apt αvβ3 -MNPs have the potential to be used for accurate tumor diagnosis and therapy.

Original languageEnglish
Pages (from-to)49-59
Number of pages11
JournalJournal of Biomedical Materials Research - Part A
Volume102
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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