Are serum vitamin D levels associated with dry eye disease? Results from the study group for environmental eye disease

Da Hye Jeon, Hyungseon Yeom, Jaewon Yang, Jong Suk Song, Hyung Keun Lee, Hyeon Chang Kim

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Objectives: Dry eye disease (DED) is an increasingly important public health problem in Korea. Previous studies conducted in Korea have reported inconsistent results regarding the protective effects of vitamin D on DED, and these discrepancies may be related to the relatively simple questionnaire that has been used. Thus, we evaluated the association of serum vitamin D levels with DED using the ocular surface disease index (OSDI). Methods: The present study evaluated data from participants in the Study Group for Environmental Eye Disease (2014-2015). This group included data from 752 participants, and data from 740 participants (253 men and 487 women) were analyzed in the present study. DED severity was evaluated using the OSDI. Results: Higher serum vitamin D levels were associated with a non-significantly reduced risk of DED in the crude analysis (odds ratio [OR], 0.991; 95% confidence interval [CI], 0.971 to 1.011) and in the adjusted analysis (OR, 0.988; 95% CI, 0.966 to 1.010). In the crude analysis of no/mild DED vs. moderate/severe DED, men exhibited a decreased risk with increasing serum vitamin D levels (OR, 0.999; 95% CI, 0.950 to 1.051), while women exhibited an increased risk (OR, 1.003; 95% CI, 0.979 to 1.027). In these analyses, we found no significant associations. Conclusions: The findings of the present study support previous reports that serum vitamin D levels are not associated with DED.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalJournal of Preventive Medicine and Public Health
Issue number6
Publication statusPublished - 2017 Nov

Bibliographical note

Funding Information:
This study was funded by the Korean Health Technology R&D Project (HI13C0055).

Publisher Copyright:
Copyright © 2017 The Korean Society for Preventive Medicine.

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Are serum vitamin D levels associated with dry eye disease? Results from the study group for environmental eye disease'. Together they form a unique fingerprint.

Cite this