Are sleep disorders associated with increased mortality in asthma patients?

Kyu Tae Han, Hong Chul Bae, Sang Gyu Lee, Seung Ju Kim, Woorim Kim, Hyo Jung Lee, Yeong Jun Ju, Euncheol Park

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: South Korea has experienced problems regarding poor management of symptoms of asthma patients and remarkable increases in sleep disorders. However, few studies have investigated these issues. We examined the relationship between sleep disorders and mortality in asthma patients to suggest effective alternatives from a novel perspective. Methods: We used data from the National Health Insurance Service (NHIS) National Sample Cohort 2004-2013, which included medical claims filed for 186,491 patients who were newly diagnosed with asthma during the study period. We performed survival analyses using a Cox proportional hazards model with time-dependent covariates to examine the relationship between sleep disorders and mortality in asthma patients. Results: There were 5179 (2.78%) patients who died during the study period. Sleep disorders in patients previously diagnosed with asthma were associated with a higher risk of mortality (hazard ratio [HR]: 1.451, 95% confidence interval [CI]: 1.253-1.681). In addition, significant interaction was found between sleep disorders and Charlson comorbidity index. Conclusions: Our findings suggest that an increased prevalence of sleep disorders in asthma patients increases the risk of mortality. Considering the worsening status of asthma management and the rapid growth of sleep disorders in South Korea, clinicians and health policymakers should work to develop interventions to address these issues.

Original languageEnglish
Article number154
JournalBMC Pulmonary Medicine
Volume16
Issue number1
DOIs
Publication statusPublished - 2016 Nov 17

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Asthma
Mortality
Republic of Korea
National Health Programs
Growth Disorders
Survival Analysis
Sleep Wake Disorders
Proportional Hazards Models
Comorbidity
Confidence Intervals
Health

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Han, Kyu Tae ; Bae, Hong Chul ; Lee, Sang Gyu ; Kim, Seung Ju ; Kim, Woorim ; Lee, Hyo Jung ; Ju, Yeong Jun ; Park, Euncheol. / Are sleep disorders associated with increased mortality in asthma patients?. In: BMC Pulmonary Medicine. 2016 ; Vol. 16, No. 1.
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abstract = "Background: South Korea has experienced problems regarding poor management of symptoms of asthma patients and remarkable increases in sleep disorders. However, few studies have investigated these issues. We examined the relationship between sleep disorders and mortality in asthma patients to suggest effective alternatives from a novel perspective. Methods: We used data from the National Health Insurance Service (NHIS) National Sample Cohort 2004-2013, which included medical claims filed for 186,491 patients who were newly diagnosed with asthma during the study period. We performed survival analyses using a Cox proportional hazards model with time-dependent covariates to examine the relationship between sleep disorders and mortality in asthma patients. Results: There were 5179 (2.78{\%}) patients who died during the study period. Sleep disorders in patients previously diagnosed with asthma were associated with a higher risk of mortality (hazard ratio [HR]: 1.451, 95{\%} confidence interval [CI]: 1.253-1.681). In addition, significant interaction was found between sleep disorders and Charlson comorbidity index. Conclusions: Our findings suggest that an increased prevalence of sleep disorders in asthma patients increases the risk of mortality. Considering the worsening status of asthma management and the rapid growth of sleep disorders in South Korea, clinicians and health policymakers should work to develop interventions to address these issues.",
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Are sleep disorders associated with increased mortality in asthma patients? / Han, Kyu Tae; Bae, Hong Chul; Lee, Sang Gyu; Kim, Seung Ju; Kim, Woorim; Lee, Hyo Jung; Ju, Yeong Jun; Park, Euncheol.

In: BMC Pulmonary Medicine, Vol. 16, No. 1, 154, 17.11.2016.

Research output: Contribution to journalArticle

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AU - Lee, Hyo Jung

AU - Ju, Yeong Jun

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