Artemisia iwayomogi extract attenuates high-fat diet-induced hypertriglyceridemia in mice: Potential involvement of the adiponectin-AMPK pathway and very low density lipoprotein assembly in the liver

Jinhui Lee, Vikram P. Narayan, Eun Young Hong, Wan Kyunn Whang, Taesun Park

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3 Citations (Scopus)

Abstract

This study aimed to examine the protective effect of Artemisia iwayomogi extract (AI) against hypertriglyceridemia induced by a high-fat diet (HFD) in mice and to uncover the underlying molecular mechanisms. C57BL/6N mice were fed chow, HFD, HFD + 0.1% AI, HFD + 0.25% AI, or HFD + 0.5% AI for 10 weeks. The addition of 0.25% and 0.5% AI resulted in dose-dependent improvements in the major parameters of hypertriglyceridemia, including plasma triglyceride, free fatty acids, apolipoprotein B, and lipoprotein lipase, with parallel reductions in body weight gain, hepatic lipid accumulation, and insulin resistance. These beneficial effects were accompanied by the activation of adiponectin-adenosine monophosphate-activated protein kinase (AMPK) mediated signaling cascades in the liver, which downregulated molecules involved in lipogenesis and concurrently upregulated molecules related to fatty acid oxidation. The downregulation of molecules involved in very low density lipoprotein assembly, which was associated with improved hepatic insulin signaling, also appeared to contribute to the AI-induced attenuation of hypertriglyceridemia.

Original languageEnglish
Article number1762
JournalInternational journal of molecular sciences
Volume18
Issue number8
DOIs
Publication statusPublished - 2017 Aug 12

Fingerprint

adenosine monophosphate
lipoproteins
Artemisia
Lipoproteins
diets
VLDL Lipoproteins
Hypertriglyceridemia
Adiponectin
fats
High Fat Diet
Adenosine Monophosphate
Nutrition
Oils and fats
liver
Liver
Protein Kinases
mice
assembly
Fats
proteins

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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title = "Artemisia iwayomogi extract attenuates high-fat diet-induced hypertriglyceridemia in mice: Potential involvement of the adiponectin-AMPK pathway and very low density lipoprotein assembly in the liver",
abstract = "This study aimed to examine the protective effect of Artemisia iwayomogi extract (AI) against hypertriglyceridemia induced by a high-fat diet (HFD) in mice and to uncover the underlying molecular mechanisms. C57BL/6N mice were fed chow, HFD, HFD + 0.1{\%} AI, HFD + 0.25{\%} AI, or HFD + 0.5{\%} AI for 10 weeks. The addition of 0.25{\%} and 0.5{\%} AI resulted in dose-dependent improvements in the major parameters of hypertriglyceridemia, including plasma triglyceride, free fatty acids, apolipoprotein B, and lipoprotein lipase, with parallel reductions in body weight gain, hepatic lipid accumulation, and insulin resistance. These beneficial effects were accompanied by the activation of adiponectin-adenosine monophosphate-activated protein kinase (AMPK) mediated signaling cascades in the liver, which downregulated molecules involved in lipogenesis and concurrently upregulated molecules related to fatty acid oxidation. The downregulation of molecules involved in very low density lipoprotein assembly, which was associated with improved hepatic insulin signaling, also appeared to contribute to the AI-induced attenuation of hypertriglyceridemia.",
author = "Jinhui Lee and Narayan, {Vikram P.} and Hong, {Eun Young} and Whang, {Wan Kyunn} and Taesun Park",
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AU - Park, Taesun

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