Arterial stiffness as a risk factor for subclinical coronary artery calcification in predialysis chronic kidney disease: From the KNOW-CKD Study

Young Youl Hyun, Hyang Kim, Kook Hwan Oh, Curie Ahn, Sue K. Park, Dong Wan Chae, Seung Hyeok Han, Yong Soo Kim, Sung Woo Lee, Chang Seong Kim, Kyu Beck Lee

Research output: Contribution to journalArticle

Abstract

Background/Aims: Both arterial stiffness and coronary artery calcification (CAC) are important predictors of cardiovascular disease in the general population and in chronic kidney disease (CKD) patients. Recent studies on arterial stiffness and CAC in subjects with preserved renal function have verified the association between the two. However, the relationship is not well evaluated in CKD patients. Methods: This cross-sectional study analyzed 1,385 predialysis CKD patients from the KNOW-CKD cohort. Participants were divided into four groups according to brachial-ankle pulse wave velocity (baPWV) quartile. Coronary artery calcium scores (CACS) were assessed using cardiac computed tomography and CAC was defined as a CACS >100. Results: CAC prevalence was higher in the higher baPWV groups (6.4, 9.8, 23.7, and 43.8% for the 1st to 4th quartiles of baPWV, respectively, p < 0.001). In Tobit regression analyses that were fully adjusted for traditional and renal cardiovascular risk factors, the CACS ratio comparing the highest and lowest baPWV quartiles was 3.03 (95% CI, 1.59-6.87). Similarly, the OR for CAC in the highest baPWV quartile compared to the lowest quartile was 1.98 (95% CI, 1.09-3.60) in a fully adjusted multivariate logistic model. Results were consistent across analyses with different cutoffs for CAC or with different clinically relevant subgroups. Conclusion: Increased arterial stiffness measured by high baPWV was associated with CAC in a predialysis CKD cohort. Longitudinal studies are needed to determine the effect of arterial stiffness on the development or progression of CAC in CKD.

Original languageEnglish
Pages (from-to)426-434
Number of pages9
JournalKidney and Blood Pressure Research
Volume44
Issue number3
DOIs
Publication statusPublished - 2019 Jun 1

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Vascular Stiffness
Chronic Renal Insufficiency
Coronary Vessels
Pulse Wave Analysis
Ankle
Arm
Calcium
Kidney
Longitudinal Studies
Cardiovascular Diseases
Cross-Sectional Studies
Logistic Models
Tomography
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Cardiology and Cardiovascular Medicine

Cite this

Hyun, Young Youl ; Kim, Hyang ; Oh, Kook Hwan ; Ahn, Curie ; Park, Sue K. ; Chae, Dong Wan ; Han, Seung Hyeok ; Kim, Yong Soo ; Lee, Sung Woo ; Kim, Chang Seong ; Lee, Kyu Beck. / Arterial stiffness as a risk factor for subclinical coronary artery calcification in predialysis chronic kidney disease : From the KNOW-CKD Study. In: Kidney and Blood Pressure Research. 2019 ; Vol. 44, No. 3. pp. 426-434.
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title = "Arterial stiffness as a risk factor for subclinical coronary artery calcification in predialysis chronic kidney disease: From the KNOW-CKD Study",
abstract = "Background/Aims: Both arterial stiffness and coronary artery calcification (CAC) are important predictors of cardiovascular disease in the general population and in chronic kidney disease (CKD) patients. Recent studies on arterial stiffness and CAC in subjects with preserved renal function have verified the association between the two. However, the relationship is not well evaluated in CKD patients. Methods: This cross-sectional study analyzed 1,385 predialysis CKD patients from the KNOW-CKD cohort. Participants were divided into four groups according to brachial-ankle pulse wave velocity (baPWV) quartile. Coronary artery calcium scores (CACS) were assessed using cardiac computed tomography and CAC was defined as a CACS >100. Results: CAC prevalence was higher in the higher baPWV groups (6.4, 9.8, 23.7, and 43.8{\%} for the 1st to 4th quartiles of baPWV, respectively, p < 0.001). In Tobit regression analyses that were fully adjusted for traditional and renal cardiovascular risk factors, the CACS ratio comparing the highest and lowest baPWV quartiles was 3.03 (95{\%} CI, 1.59-6.87). Similarly, the OR for CAC in the highest baPWV quartile compared to the lowest quartile was 1.98 (95{\%} CI, 1.09-3.60) in a fully adjusted multivariate logistic model. Results were consistent across analyses with different cutoffs for CAC or with different clinically relevant subgroups. Conclusion: Increased arterial stiffness measured by high baPWV was associated with CAC in a predialysis CKD cohort. Longitudinal studies are needed to determine the effect of arterial stiffness on the development or progression of CAC in CKD.",
author = "Hyun, {Young Youl} and Hyang Kim and Oh, {Kook Hwan} and Curie Ahn and Park, {Sue K.} and Chae, {Dong Wan} and Han, {Seung Hyeok} and Kim, {Yong Soo} and Lee, {Sung Woo} and Kim, {Chang Seong} and Lee, {Kyu Beck}",
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Arterial stiffness as a risk factor for subclinical coronary artery calcification in predialysis chronic kidney disease : From the KNOW-CKD Study. / Hyun, Young Youl; Kim, Hyang; Oh, Kook Hwan; Ahn, Curie; Park, Sue K.; Chae, Dong Wan; Han, Seung Hyeok; Kim, Yong Soo; Lee, Sung Woo; Kim, Chang Seong; Lee, Kyu Beck.

In: Kidney and Blood Pressure Research, Vol. 44, No. 3, 01.06.2019, p. 426-434.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Arterial stiffness as a risk factor for subclinical coronary artery calcification in predialysis chronic kidney disease

T2 - From the KNOW-CKD Study

AU - Hyun, Young Youl

AU - Kim, Hyang

AU - Oh, Kook Hwan

AU - Ahn, Curie

AU - Park, Sue K.

AU - Chae, Dong Wan

AU - Han, Seung Hyeok

AU - Kim, Yong Soo

AU - Lee, Sung Woo

AU - Kim, Chang Seong

AU - Lee, Kyu Beck

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background/Aims: Both arterial stiffness and coronary artery calcification (CAC) are important predictors of cardiovascular disease in the general population and in chronic kidney disease (CKD) patients. Recent studies on arterial stiffness and CAC in subjects with preserved renal function have verified the association between the two. However, the relationship is not well evaluated in CKD patients. Methods: This cross-sectional study analyzed 1,385 predialysis CKD patients from the KNOW-CKD cohort. Participants were divided into four groups according to brachial-ankle pulse wave velocity (baPWV) quartile. Coronary artery calcium scores (CACS) were assessed using cardiac computed tomography and CAC was defined as a CACS >100. Results: CAC prevalence was higher in the higher baPWV groups (6.4, 9.8, 23.7, and 43.8% for the 1st to 4th quartiles of baPWV, respectively, p < 0.001). In Tobit regression analyses that were fully adjusted for traditional and renal cardiovascular risk factors, the CACS ratio comparing the highest and lowest baPWV quartiles was 3.03 (95% CI, 1.59-6.87). Similarly, the OR for CAC in the highest baPWV quartile compared to the lowest quartile was 1.98 (95% CI, 1.09-3.60) in a fully adjusted multivariate logistic model. Results were consistent across analyses with different cutoffs for CAC or with different clinically relevant subgroups. Conclusion: Increased arterial stiffness measured by high baPWV was associated with CAC in a predialysis CKD cohort. Longitudinal studies are needed to determine the effect of arterial stiffness on the development or progression of CAC in CKD.

AB - Background/Aims: Both arterial stiffness and coronary artery calcification (CAC) are important predictors of cardiovascular disease in the general population and in chronic kidney disease (CKD) patients. Recent studies on arterial stiffness and CAC in subjects with preserved renal function have verified the association between the two. However, the relationship is not well evaluated in CKD patients. Methods: This cross-sectional study analyzed 1,385 predialysis CKD patients from the KNOW-CKD cohort. Participants were divided into four groups according to brachial-ankle pulse wave velocity (baPWV) quartile. Coronary artery calcium scores (CACS) were assessed using cardiac computed tomography and CAC was defined as a CACS >100. Results: CAC prevalence was higher in the higher baPWV groups (6.4, 9.8, 23.7, and 43.8% for the 1st to 4th quartiles of baPWV, respectively, p < 0.001). In Tobit regression analyses that were fully adjusted for traditional and renal cardiovascular risk factors, the CACS ratio comparing the highest and lowest baPWV quartiles was 3.03 (95% CI, 1.59-6.87). Similarly, the OR for CAC in the highest baPWV quartile compared to the lowest quartile was 1.98 (95% CI, 1.09-3.60) in a fully adjusted multivariate logistic model. Results were consistent across analyses with different cutoffs for CAC or with different clinically relevant subgroups. Conclusion: Increased arterial stiffness measured by high baPWV was associated with CAC in a predialysis CKD cohort. Longitudinal studies are needed to determine the effect of arterial stiffness on the development or progression of CAC in CKD.

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