Arterial stiffness as a risk factor for subclinical coronary artery calcification in predialysis chronic kidney disease: From the KNOW-CKD Study

Young Youl Hyun, Hyang Kim, Kook Hwan Oh, Curie Ahn, Sue K. Park, Dong Wan Chae, Seung Hyeok Han, Yong Soo Kim, Sung Woo Lee, Chang Seong Kim, Kyu Beck Lee

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background/Aims: Both arterial stiffness and coronary artery calcification (CAC) are important predictors of cardiovascular disease in the general population and in chronic kidney disease (CKD) patients. Recent studies on arterial stiffness and CAC in subjects with preserved renal function have verified the association between the two. However, the relationship is not well evaluated in CKD patients. Methods: This cross-sectional study analyzed 1,385 predialysis CKD patients from the KNOW-CKD cohort. Participants were divided into four groups according to brachial-ankle pulse wave velocity (baPWV) quartile. Coronary artery calcium scores (CACS) were assessed using cardiac computed tomography and CAC was defined as a CACS >100. Results: CAC prevalence was higher in the higher baPWV groups (6.4, 9.8, 23.7, and 43.8% for the 1st to 4th quartiles of baPWV, respectively, p < 0.001). In Tobit regression analyses that were fully adjusted for traditional and renal cardiovascular risk factors, the CACS ratio comparing the highest and lowest baPWV quartiles was 3.03 (95% CI, 1.59-6.87). Similarly, the OR for CAC in the highest baPWV quartile compared to the lowest quartile was 1.98 (95% CI, 1.09-3.60) in a fully adjusted multivariate logistic model. Results were consistent across analyses with different cutoffs for CAC or with different clinically relevant subgroups. Conclusion: Increased arterial stiffness measured by high baPWV was associated with CAC in a predialysis CKD cohort. Longitudinal studies are needed to determine the effect of arterial stiffness on the development or progression of CAC in CKD.

Original languageEnglish
Pages (from-to)426-434
Number of pages9
JournalKidney and Blood Pressure Research
Issue number3
Publication statusPublished - 2019 Jun 1

Bibliographical note

Funding Information:
This work was supported by the Research Program funded by the Korea Centers for Disease Control and Prevention (2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201).

Publisher Copyright:
© 2019 The Author(s) Published by S. Karger AG, Basel.

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Arterial stiffness as a risk factor for subclinical coronary artery calcification in predialysis chronic kidney disease: From the KNOW-CKD Study'. Together they form a unique fingerprint.

Cite this