Arterial stiffness is associated with cytomegalovirus-specific senescent CD8+ T Cells

Hee Tae Yu, Jong Chan Youn, Jong Hoon Kim, Yeon Jae Seong, Su Hyung Park, Hyeon Chang Kim, Won Woo Lee, Sungha Park, Eui Cheol Shin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background--Arterial stiffness is a well-known predictor of future cardiovascular events. Search for the underlying mechanism of arterial stiffening is still under way. We investigated the relationship between arterial stiffness and cytomegalovirus infection in terms of T-cell senescence. Methods and Results--Arterial stiffness was evaluated using pulse wave velocity measurements in 415 Koreans (age 59±12 years). We also investigated the frequency of CD57+ or CD28null senescent T cells in peripheral blood lymphocytes and analyzed which immune parameters were correlated with pulse wave velocity. Furthermore, cytomegalovirus-specific T cells were stimulated with overlapping peptides covering pp65 protein, and T-cell function was evaluated by intracellular cytokine staining of interferon-γ, tumor necrosis factor-α, and CD107a. In a multivariate analysis, it was found that the frequency of CD57+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity after adjusting for traditional cardiovascular risk factors such as age, sex, diabetes mellitus history, smoking history, body mass index, blood pressure, serum creatinine, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein. Cytomegalovirus pp65-specific T cells were more frequently observed in the CD8+CD57+ population than in the CD8+CD57- population, and multivariate analysis revealed that the frequency of cytomegalovirus pp65-specific interferon-γ+, tumor necrosis factor-α+, or CD107a+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity as well. Conclusions--We demonstrate that arterial stiffness is associated with senescent CD57+ T cells and CMV pp65-specific T cells in the CD8+ T-cell subset. The precise role of cytomegalovirus-specific, senescent T cells in vascular aging needs to be further investigated.

Original languageEnglish
Article numbere006535
JournalJournal of the American Heart Association
Volume6
Issue number9
DOIs
Publication statusPublished - 2017 Sep 1

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Vascular Stiffness
Cytomegalovirus
T-Lymphocytes
Pulse Wave Analysis
T-Lymphocyte Subsets
Interferons
Multivariate Analysis
Tumor Necrosis Factor-alpha
Cell Aging
Cytomegalovirus Infections
C-Reactive Protein
HDL Cholesterol
Population
Blood Vessels
Creatinine
Diabetes Mellitus
Body Mass Index
Smoking
History
Lymphocytes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Yu, Hee Tae ; Youn, Jong Chan ; Kim, Jong Hoon ; Seong, Yeon Jae ; Park, Su Hyung ; Kim, Hyeon Chang ; Lee, Won Woo ; Park, Sungha ; Shin, Eui Cheol. / Arterial stiffness is associated with cytomegalovirus-specific senescent CD8+ T Cells. In: Journal of the American Heart Association. 2017 ; Vol. 6, No. 9.
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abstract = "Background--Arterial stiffness is a well-known predictor of future cardiovascular events. Search for the underlying mechanism of arterial stiffening is still under way. We investigated the relationship between arterial stiffness and cytomegalovirus infection in terms of T-cell senescence. Methods and Results--Arterial stiffness was evaluated using pulse wave velocity measurements in 415 Koreans (age 59±12 years). We also investigated the frequency of CD57+ or CD28null senescent T cells in peripheral blood lymphocytes and analyzed which immune parameters were correlated with pulse wave velocity. Furthermore, cytomegalovirus-specific T cells were stimulated with overlapping peptides covering pp65 protein, and T-cell function was evaluated by intracellular cytokine staining of interferon-γ, tumor necrosis factor-α, and CD107a. In a multivariate analysis, it was found that the frequency of CD57+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity after adjusting for traditional cardiovascular risk factors such as age, sex, diabetes mellitus history, smoking history, body mass index, blood pressure, serum creatinine, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein. Cytomegalovirus pp65-specific T cells were more frequently observed in the CD8+CD57+ population than in the CD8+CD57- population, and multivariate analysis revealed that the frequency of cytomegalovirus pp65-specific interferon-γ+, tumor necrosis factor-α+, or CD107a+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity as well. Conclusions--We demonstrate that arterial stiffness is associated with senescent CD57+ T cells and CMV pp65-specific T cells in the CD8+ T-cell subset. The precise role of cytomegalovirus-specific, senescent T cells in vascular aging needs to be further investigated.",
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Arterial stiffness is associated with cytomegalovirus-specific senescent CD8+ T Cells. / Yu, Hee Tae; Youn, Jong Chan; Kim, Jong Hoon; Seong, Yeon Jae; Park, Su Hyung; Kim, Hyeon Chang; Lee, Won Woo; Park, Sungha; Shin, Eui Cheol.

In: Journal of the American Heart Association, Vol. 6, No. 9, e006535, 01.09.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Arterial stiffness is associated with cytomegalovirus-specific senescent CD8+ T Cells

AU - Yu, Hee Tae

AU - Youn, Jong Chan

AU - Kim, Jong Hoon

AU - Seong, Yeon Jae

AU - Park, Su Hyung

AU - Kim, Hyeon Chang

AU - Lee, Won Woo

AU - Park, Sungha

AU - Shin, Eui Cheol

PY - 2017/9/1

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N2 - Background--Arterial stiffness is a well-known predictor of future cardiovascular events. Search for the underlying mechanism of arterial stiffening is still under way. We investigated the relationship between arterial stiffness and cytomegalovirus infection in terms of T-cell senescence. Methods and Results--Arterial stiffness was evaluated using pulse wave velocity measurements in 415 Koreans (age 59±12 years). We also investigated the frequency of CD57+ or CD28null senescent T cells in peripheral blood lymphocytes and analyzed which immune parameters were correlated with pulse wave velocity. Furthermore, cytomegalovirus-specific T cells were stimulated with overlapping peptides covering pp65 protein, and T-cell function was evaluated by intracellular cytokine staining of interferon-γ, tumor necrosis factor-α, and CD107a. In a multivariate analysis, it was found that the frequency of CD57+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity after adjusting for traditional cardiovascular risk factors such as age, sex, diabetes mellitus history, smoking history, body mass index, blood pressure, serum creatinine, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein. Cytomegalovirus pp65-specific T cells were more frequently observed in the CD8+CD57+ population than in the CD8+CD57- population, and multivariate analysis revealed that the frequency of cytomegalovirus pp65-specific interferon-γ+, tumor necrosis factor-α+, or CD107a+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity as well. Conclusions--We demonstrate that arterial stiffness is associated with senescent CD57+ T cells and CMV pp65-specific T cells in the CD8+ T-cell subset. The precise role of cytomegalovirus-specific, senescent T cells in vascular aging needs to be further investigated.

AB - Background--Arterial stiffness is a well-known predictor of future cardiovascular events. Search for the underlying mechanism of arterial stiffening is still under way. We investigated the relationship between arterial stiffness and cytomegalovirus infection in terms of T-cell senescence. Methods and Results--Arterial stiffness was evaluated using pulse wave velocity measurements in 415 Koreans (age 59±12 years). We also investigated the frequency of CD57+ or CD28null senescent T cells in peripheral blood lymphocytes and analyzed which immune parameters were correlated with pulse wave velocity. Furthermore, cytomegalovirus-specific T cells were stimulated with overlapping peptides covering pp65 protein, and T-cell function was evaluated by intracellular cytokine staining of interferon-γ, tumor necrosis factor-α, and CD107a. In a multivariate analysis, it was found that the frequency of CD57+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity after adjusting for traditional cardiovascular risk factors such as age, sex, diabetes mellitus history, smoking history, body mass index, blood pressure, serum creatinine, high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein. Cytomegalovirus pp65-specific T cells were more frequently observed in the CD8+CD57+ population than in the CD8+CD57- population, and multivariate analysis revealed that the frequency of cytomegalovirus pp65-specific interferon-γ+, tumor necrosis factor-α+, or CD107a+ cells in the CD8+ T-cell subset was independently correlated with pulse wave velocity as well. Conclusions--We demonstrate that arterial stiffness is associated with senescent CD57+ T cells and CMV pp65-specific T cells in the CD8+ T-cell subset. The precise role of cytomegalovirus-specific, senescent T cells in vascular aging needs to be further investigated.

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