Arterial stiffness is related to augmented seasonal variation of blood pressure in hypertensive patients

Jong Chan Youn, Se Joong Rim, Sungha Park, Young Guk Ko, Seok Min Kang, Donghoon Choi, Jong Won Ha, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background. Seasonal variation in blood pressure (BP), a usual tendency of both systolic (SBP) and diastolic BP (DBP) to rise during winter in hypertensive patients, may be related to the higher cardiovascular mortality in winter. However, it is not yet clear what factors are relevant to the seasonal BP changes. We hypothesized that arterial stiffness is related to the BP changes between summer and winter. Methods and results. Eighty-five elderly (>55 years) patients with essential hypertension (33 males, 64 ± 6.0 years) were enrolled. Seasonal BP profiles over at least 2 years were studied along with arterial stiffness and clinical variables (age, gender, smoking, duration of hypertension, anti-hypertensive medications and body mass index). Both SBP and DBP were significantly higher during winter compared with three other seasons (spring 128 ± 10.0/79 ± 7.3 mmHg, summer 127 ± 9.8/78 ± 7.1 mmHg, autumn 127 ± 10.3/78 ± 8.0 mmHg, winter 136 ± 12.5/81 ± 7.6 mmHg; SBP changes; p < 0.001, DBP changes; p < 0.001). There were no significant seasonal differences among spring, summer and autumn. Pulse wave velocity (PWV), a widely used clinical indicator of arterial stiffness was correlated with winter-summer differences in SBP (r = 0.272, p = 0.012), but not in DBP (r = 0.188, p = 0.085). Age, which was correlated with PWV strongly (p < 0.001), was not significantly related to the seasonal changes in BP (SBP changes; p = 0.114, DBP changes; p = 0.298). No other clinical variables had significant correlation with seasonal BP changes. Multivariate regression analysis revealed that PWV is the only significant predictor for winter-summer SBP changes. Conclusions. Our results established a feasible link between arterial stiffness and seasonal BP variation. These findings may partly explain higher cardiovascular risk in patients with increased arterial stiffness.

Original languageEnglish
Pages (from-to)375-380
Number of pages6
JournalBlood Pressure
Volume16
Issue number6
DOIs
Publication statusPublished - 2007 Dec 14

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Vascular Stiffness
Blood Pressure
Pulse Wave Analysis
Antihypertensive Agents
Body Mass Index
Multivariate Analysis
Smoking
Regression Analysis
Hypertension
Mortality

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Youn, Jong Chan ; Rim, Se Joong ; Park, Sungha ; Ko, Young Guk ; Kang, Seok Min ; Choi, Donghoon ; Ha, Jong Won ; Jang, Yangsoo ; Chung, Namsik. / Arterial stiffness is related to augmented seasonal variation of blood pressure in hypertensive patients. In: Blood Pressure. 2007 ; Vol. 16, No. 6. pp. 375-380.
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title = "Arterial stiffness is related to augmented seasonal variation of blood pressure in hypertensive patients",
abstract = "Background. Seasonal variation in blood pressure (BP), a usual tendency of both systolic (SBP) and diastolic BP (DBP) to rise during winter in hypertensive patients, may be related to the higher cardiovascular mortality in winter. However, it is not yet clear what factors are relevant to the seasonal BP changes. We hypothesized that arterial stiffness is related to the BP changes between summer and winter. Methods and results. Eighty-five elderly (>55 years) patients with essential hypertension (33 males, 64 ± 6.0 years) were enrolled. Seasonal BP profiles over at least 2 years were studied along with arterial stiffness and clinical variables (age, gender, smoking, duration of hypertension, anti-hypertensive medications and body mass index). Both SBP and DBP were significantly higher during winter compared with three other seasons (spring 128 ± 10.0/79 ± 7.3 mmHg, summer 127 ± 9.8/78 ± 7.1 mmHg, autumn 127 ± 10.3/78 ± 8.0 mmHg, winter 136 ± 12.5/81 ± 7.6 mmHg; SBP changes; p < 0.001, DBP changes; p < 0.001). There were no significant seasonal differences among spring, summer and autumn. Pulse wave velocity (PWV), a widely used clinical indicator of arterial stiffness was correlated with winter-summer differences in SBP (r = 0.272, p = 0.012), but not in DBP (r = 0.188, p = 0.085). Age, which was correlated with PWV strongly (p < 0.001), was not significantly related to the seasonal changes in BP (SBP changes; p = 0.114, DBP changes; p = 0.298). No other clinical variables had significant correlation with seasonal BP changes. Multivariate regression analysis revealed that PWV is the only significant predictor for winter-summer SBP changes. Conclusions. Our results established a feasible link between arterial stiffness and seasonal BP variation. These findings may partly explain higher cardiovascular risk in patients with increased arterial stiffness.",
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Arterial stiffness is related to augmented seasonal variation of blood pressure in hypertensive patients. / Youn, Jong Chan; Rim, Se Joong; Park, Sungha; Ko, Young Guk; Kang, Seok Min; Choi, Donghoon; Ha, Jong Won; Jang, Yangsoo; Chung, Namsik.

In: Blood Pressure, Vol. 16, No. 6, 14.12.2007, p. 375-380.

Research output: Contribution to journalArticle

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T1 - Arterial stiffness is related to augmented seasonal variation of blood pressure in hypertensive patients

AU - Youn, Jong Chan

AU - Rim, Se Joong

AU - Park, Sungha

AU - Ko, Young Guk

AU - Kang, Seok Min

AU - Choi, Donghoon

AU - Ha, Jong Won

AU - Jang, Yangsoo

AU - Chung, Namsik

PY - 2007/12/14

Y1 - 2007/12/14

N2 - Background. Seasonal variation in blood pressure (BP), a usual tendency of both systolic (SBP) and diastolic BP (DBP) to rise during winter in hypertensive patients, may be related to the higher cardiovascular mortality in winter. However, it is not yet clear what factors are relevant to the seasonal BP changes. We hypothesized that arterial stiffness is related to the BP changes between summer and winter. Methods and results. Eighty-five elderly (>55 years) patients with essential hypertension (33 males, 64 ± 6.0 years) were enrolled. Seasonal BP profiles over at least 2 years were studied along with arterial stiffness and clinical variables (age, gender, smoking, duration of hypertension, anti-hypertensive medications and body mass index). Both SBP and DBP were significantly higher during winter compared with three other seasons (spring 128 ± 10.0/79 ± 7.3 mmHg, summer 127 ± 9.8/78 ± 7.1 mmHg, autumn 127 ± 10.3/78 ± 8.0 mmHg, winter 136 ± 12.5/81 ± 7.6 mmHg; SBP changes; p < 0.001, DBP changes; p < 0.001). There were no significant seasonal differences among spring, summer and autumn. Pulse wave velocity (PWV), a widely used clinical indicator of arterial stiffness was correlated with winter-summer differences in SBP (r = 0.272, p = 0.012), but not in DBP (r = 0.188, p = 0.085). Age, which was correlated with PWV strongly (p < 0.001), was not significantly related to the seasonal changes in BP (SBP changes; p = 0.114, DBP changes; p = 0.298). No other clinical variables had significant correlation with seasonal BP changes. Multivariate regression analysis revealed that PWV is the only significant predictor for winter-summer SBP changes. Conclusions. Our results established a feasible link between arterial stiffness and seasonal BP variation. These findings may partly explain higher cardiovascular risk in patients with increased arterial stiffness.

AB - Background. Seasonal variation in blood pressure (BP), a usual tendency of both systolic (SBP) and diastolic BP (DBP) to rise during winter in hypertensive patients, may be related to the higher cardiovascular mortality in winter. However, it is not yet clear what factors are relevant to the seasonal BP changes. We hypothesized that arterial stiffness is related to the BP changes between summer and winter. Methods and results. Eighty-five elderly (>55 years) patients with essential hypertension (33 males, 64 ± 6.0 years) were enrolled. Seasonal BP profiles over at least 2 years were studied along with arterial stiffness and clinical variables (age, gender, smoking, duration of hypertension, anti-hypertensive medications and body mass index). Both SBP and DBP were significantly higher during winter compared with three other seasons (spring 128 ± 10.0/79 ± 7.3 mmHg, summer 127 ± 9.8/78 ± 7.1 mmHg, autumn 127 ± 10.3/78 ± 8.0 mmHg, winter 136 ± 12.5/81 ± 7.6 mmHg; SBP changes; p < 0.001, DBP changes; p < 0.001). There were no significant seasonal differences among spring, summer and autumn. Pulse wave velocity (PWV), a widely used clinical indicator of arterial stiffness was correlated with winter-summer differences in SBP (r = 0.272, p = 0.012), but not in DBP (r = 0.188, p = 0.085). Age, which was correlated with PWV strongly (p < 0.001), was not significantly related to the seasonal changes in BP (SBP changes; p = 0.114, DBP changes; p = 0.298). No other clinical variables had significant correlation with seasonal BP changes. Multivariate regression analysis revealed that PWV is the only significant predictor for winter-summer SBP changes. Conclusions. Our results established a feasible link between arterial stiffness and seasonal BP variation. These findings may partly explain higher cardiovascular risk in patients with increased arterial stiffness.

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