Various artificial transmembrane transporters, designed to function through mobile carrier or channel mechanisms, have been developed in the past decade. With the aid of structural manipulation and by employing either discrete chemical entities or self-assembled nanostructures, progress has been made in achieving the selective recognition and transmembrane transport of key ions. The ability to perturb intracellular pH or disrupt intracellular ion homeostasis makes transmembrane ion transporters of interest as potential therapeutics that might see use as cancer treatments or as antibacterial agents. In this review, recent progress in the area of artificial transmembrane ion transporter research is summarized with an emphasis on applications involving anticancer research and antibiotic applications. The examples chosen for highlights are meant to be illustrative of key themes involving synthetic ion transport rather than comprehensive. Nevertheless, it is anticipated that this review will provide a useful entry point for the general reader and set the stage for further progress in the area.
|Number of pages||36|
|Publication status||Published - 2021 Dec 9|
Bibliographical noteFunding Information:
This work was supported in part by the Start-up Fund of the Nanjing Forestry University . J.Y. thanks the National Natural Science Foundation of China ( 22101134 ) for financial support. G.C.Y. thanks the startup funding from Tsinghua University for support. J.L.S. thanks the Robert A. Welch Foundation ( F-0018 ) for support. I.S. thanks the National Research Foundation of Korea ( 2020R1A2C3003462 ) for funding. P.A.G. acknowledges and pays respect to the Gadigal people of the Eora Nation, the traditional owners of the land on which we research, teach, and collaborate at the University of Sydney. P.A.G. thanks the Australian Research Council ( DP180100612 and DP200100453 ) and the University of Sydney for funding. F.H. thanks the National Natural Science Foundation of China ( 22035006 ) and Zhejiang Provincial Natural Science Foundation of China ( LD21B020001 ) for financial support.
© 2021 Elsevier Inc.
All Science Journal Classification (ASJC) codes
- Environmental Chemistry
- Chemical Engineering(all)
- Biochemistry, medical
- Materials Chemistry