Artificial transmembrane ion transporters as potential therapeutics

Jie Yang; Guocan Yu; Jonathan L. Sessler; Injae Shin; Philip A. Gale; Feihe Huang

doi:10.1016/j.chempr.2021.10.028

Artificial transmembrane ion transporters as potential therapeutics

Jie Yang, Guocan Yu, Jonathan L. Sessler, Injae Shin, Philip A. Gale, Feihe Huang

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Various artificial transmembrane transporters, designed to function through mobile carrier or channel mechanisms, have been developed in the past decade. With the aid of structural manipulation and by employing either discrete chemical entities or self-assembled nanostructures, progress has been made in achieving the selective recognition and transmembrane transport of key ions. The ability to perturb intracellular pH or disrupt intracellular ion homeostasis makes transmembrane ion transporters of interest as potential therapeutics that might see use as cancer treatments or as antibacterial agents. In this review, recent progress in the area of artificial transmembrane ion transporter research is summarized with an emphasis on applications involving anticancer research and antibiotic applications. The examples chosen for highlights are meant to be illustrative of key themes involving synthetic ion transport rather than comprehensive. Nevertheless, it is anticipated that this review will provide a useful entry point for the general reader and set the stage for further progress in the area.

Original language	English
Pages (from-to)	3256-3291
Number of pages	36
Journal	Chem
Volume	7
Issue number	12
DOIs	https://doi.org/10.1016/j.chempr.2021.10.028
Publication status	Published - 2021 Dec 9

Bibliographical note

Funding Information:
This work was supported in part by the Start-up Fund of the Nanjing Forestry University . J.Y. thanks the National Natural Science Foundation of China ( 22101134 ) for financial support. G.C.Y. thanks the startup funding from Tsinghua University for support. J.L.S. thanks the Robert A. Welch Foundation ( F-0018 ) for support. I.S. thanks the National Research Foundation of Korea ( 2020R1A2C3003462 ) for funding. P.A.G. acknowledges and pays respect to the Gadigal people of the Eora Nation, the traditional owners of the land on which we research, teach, and collaborate at the University of Sydney. P.A.G. thanks the Australian Research Council ( DP180100612 and DP200100453 ) and the University of Sydney for funding. F.H. thanks the National Natural Science Foundation of China ( 22035006 ) and Zhejiang Provincial Natural Science Foundation of China ( LD21B020001 ) for financial support.

Publisher Copyright:
© 2021 Elsevier Inc.

All Science Journal Classification (ASJC) codes

Chemistry(all)
Biochemistry
Environmental Chemistry
Chemical Engineering(all)
Biochemistry, medical
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.chempr.2021.10.028

Cite this

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abstract = "Various artificial transmembrane transporters, designed to function through mobile carrier or channel mechanisms, have been developed in the past decade. With the aid of structural manipulation and by employing either discrete chemical entities or self-assembled nanostructures, progress has been made in achieving the selective recognition and transmembrane transport of key ions. The ability to perturb intracellular pH or disrupt intracellular ion homeostasis makes transmembrane ion transporters of interest as potential therapeutics that might see use as cancer treatments or as antibacterial agents. In this review, recent progress in the area of artificial transmembrane ion transporter research is summarized with an emphasis on applications involving anticancer research and antibiotic applications. The examples chosen for highlights are meant to be illustrative of key themes involving synthetic ion transport rather than comprehensive. Nevertheless, it is anticipated that this review will provide a useful entry point for the general reader and set the stage for further progress in the area.",

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note = "Funding Information: This work was supported in part by the Start-up Fund of the Nanjing Forestry University . J.Y. thanks the National Natural Science Foundation of China ( 22101134 ) for financial support. G.C.Y. thanks the startup funding from Tsinghua University for support. J.L.S. thanks the Robert A. Welch Foundation ( F-0018 ) for support. I.S. thanks the National Research Foundation of Korea ( 2020R1A2C3003462 ) for funding. P.A.G. acknowledges and pays respect to the Gadigal people of the Eora Nation, the traditional owners of the land on which we research, teach, and collaborate at the University of Sydney. P.A.G. thanks the Australian Research Council ( DP180100612 and DP200100453 ) and the University of Sydney for funding. F.H. thanks the National Natural Science Foundation of China ( 22035006 ) and Zhejiang Provincial Natural Science Foundation of China ( LD21B020001 ) for financial support. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

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Artificial transmembrane ion transporters as potential therapeutics

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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