Successful development of ultra-sensitive molecular imaging nanoprobes for the detection of targeted biological objects is a challenging task. Although magnetic nanoprobes have the potential to perform such a role, the results from probes that are currently available have been far from optimal. Here we used artificial engineering approaches to develop innovative magnetic nanoprobes, through a process that involved the systematic evaluation of the magnetic spin, size and type of spinel metal ferrites. These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available. Also, we successfully visualized small tumors implanted in a mouse. Such high-performance, nanotechnology-based molecular probes could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.
Bibliographical noteFunding Information:
We would like to thank J.-S. Shin and K.-S. Kim for discussions, Y.-J. Kim for MR imaging, E.-S. Lee (Yonsei) and H.-J. Ko (Yonsei) for cell culture, J.-M. Oh (Chuncheon-Korea Basic Science Institute) for transmission electron microscopy (TEM), J.-g. Kim for high-voltage electron microscopic analyses, H.C. Kim for superconducting quantum interference device (SQUID) analyses, K.G. Cho for CLIO synthesis and J.D. Lee for the biodistribution study. This work was supported in part by the National Research Laboratory (M10600000255), National Cancer Institute Center for Cancer Nanotechnology Excellence, National Core Research Center (R15-2004-024-02002-0), the National R&D Program for Cancer Control of the Ministry of Health & Welfare (0320250-2), and the Korea Research Foundation (2004-003-E00171) and Second Stage of Brain Korea 21 of Chemistry and Medicine.
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)