Ascidian-Inspired Fast-Forming Hydrogel System for Versatile Biomedical Applications: Pyrogallol Chemistry for Dual Modes of Crosslinking Mechanism

Jung Ho Cho, Jung Seung Lee, Jisoo Shin, Eun Je Jeon, Soohwan An, Yi Sun Choi, Seung-Woo Cho

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Exploitation of unique biochemical and biophysical properties of marine organisms has led to the development of functional biomaterials for various biomedical applications. Recently, ascidians have received great attention, owing to their extraordinary properties such as strong underwater adhesion and rapid self-regeneration. Specific polypeptides containing 3,4,5-trihydroxyphenylalanine (TOPA) in the blood cells of ascidians are associated with such intrinsic properties generated through complex oxidative processes. In this study, a bioinspired hydrogel platform is developed, demonstrating versatile applicability for tissue engineering and drug delivery, by conjugating pyrogallol (PG) moiety resembling ascidian TOPA to hyaluronic acid (HA). The HA–PG conjugate can be rapidly crosslinked by dual modes of oxidative mechanisms using an oxidant or pH control, resulting in hydrogels with different mechanical and physical characteristics. The versatile utility of HA–PG hydrogels formed via different crosslinking mechanisms is tested for different biomedical platforms, including microparticles for sustained drug delivery and tissue adhesive for noninvasive cell transplantation. With extraordinarily fast and different routes of PG oxidation, ascidian-inspired HA–PG hydrogel system may provide a promising biomaterial platform for a wide range of biomedical applications.

Original languageEnglish
Article number1705244
JournalAdvanced Functional Materials
Volume28
Issue number6
DOIs
Publication statusPublished - 2018 Feb 7

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrochemistry

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