Abstract
Mitochondrial biogenesis-a process that leads to an increment in the number and density of mitochondria, improves physical performance and body health by enhancing exercise capacity. In the present study, we investigated the stimulatory effect of Ashitaba and red ginseng complex (ARC) on exercise capacity in L6 skeletal muscle cells and mice. In L6 skeletal muscle cells, ARC increased the mitochondrial contents and ATP production by activating AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1), and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and up-regulating the mRNA expression of nuclear respiratory factor-1 (NRF-1) and mitochondrial transcription factor A (TFAM). In the animal experiments, mice treated with ARC showed an increment in exercise capacity as compared with mice treated with Ashitaba extract or red ginseng extract alone. These studies indicate that ARC might serve as a potential natural candidate for enhancing exercise capacity by stimulation of mitochondrial biogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 685-692 |
| Number of pages | 8 |
| Journal | Korean Journal of Food Science and Technology |
| Volume | 49 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2017 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Food Science
- Applied Microbiology and Biotechnology
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Ashitaba and red ginseng complex stimulates exercise capacity by increasing mitochondrial biogenesis. / Kim, Changhee; Kim, Mi Bo; Lee, Seung Ho; Kim, Ye Jin; Hwang, Jae Kwan.
In: Korean Journal of Food Science and Technology, Vol. 49, No. 6, 01.01.2017, p. 685-692.Research output: Contribution to journal › Article
TY - JOUR
T1 - Ashitaba and red ginseng complex stimulates exercise capacity by increasing mitochondrial biogenesis
AU - Kim, Changhee
AU - Kim, Mi Bo
AU - Lee, Seung Ho
AU - Kim, Ye Jin
AU - Hwang, Jae Kwan
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Mitochondrial biogenesis-a process that leads to an increment in the number and density of mitochondria, improves physical performance and body health by enhancing exercise capacity. In the present study, we investigated the stimulatory effect of Ashitaba and red ginseng complex (ARC) on exercise capacity in L6 skeletal muscle cells and mice. In L6 skeletal muscle cells, ARC increased the mitochondrial contents and ATP production by activating AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1), and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and up-regulating the mRNA expression of nuclear respiratory factor-1 (NRF-1) and mitochondrial transcription factor A (TFAM). In the animal experiments, mice treated with ARC showed an increment in exercise capacity as compared with mice treated with Ashitaba extract or red ginseng extract alone. These studies indicate that ARC might serve as a potential natural candidate for enhancing exercise capacity by stimulation of mitochondrial biogenesis.
AB - Mitochondrial biogenesis-a process that leads to an increment in the number and density of mitochondria, improves physical performance and body health by enhancing exercise capacity. In the present study, we investigated the stimulatory effect of Ashitaba and red ginseng complex (ARC) on exercise capacity in L6 skeletal muscle cells and mice. In L6 skeletal muscle cells, ARC increased the mitochondrial contents and ATP production by activating AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1), and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and up-regulating the mRNA expression of nuclear respiratory factor-1 (NRF-1) and mitochondrial transcription factor A (TFAM). In the animal experiments, mice treated with ARC showed an increment in exercise capacity as compared with mice treated with Ashitaba extract or red ginseng extract alone. These studies indicate that ARC might serve as a potential natural candidate for enhancing exercise capacity by stimulation of mitochondrial biogenesis.
UR - http://www.scopus.com/inward/record.url?scp=85042396031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042396031&partnerID=8YFLogxK
U2 - 10.9721/KJFST.2017.49.6.685
DO - 10.9721/KJFST.2017.49.6.685
M3 - Article
VL - 49
SP - 685
EP - 692
JO - Korean Journal of Food Science and Technology
JF - Korean Journal of Food Science and Technology
SN - 0367-6293
IS - 6
ER -