Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model

Jeong Hyun Lee, Hye Lee Kim, Mi Hee Lee, Kyung Eun You, Byeong Ju Kwon, Hyok Jin Seo, Jong Chul Park

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Wound healing proceeds through a complex collaborative process involving many types of cells. Keratinocytes and fibroblasts of epidermal and dermal layers of the skin play prominent roles in this process. Asiaticoside, an active component of Centella asiatica, is known for beneficial effects on keloid and hypertrophic scar. However, the effects of this compound on normal human skin cells are not well known. Using in vitro systems, we observed the effects of asiaticoside on normal human skin cell behaviors related to healing. In a wound closure seeding model, asiaticoside increased migration rates of skin cells. By observing the numbers of cells attached and the area occupied by the cells, we concluded that asiaticoside also enhanced the initial skin cell adhesion. In cell proliferation assays, asiaticoside induced an increase in the number of normal human dermal fibroblasts. In conclusion, asiaticoside promotes skin cell behaviors involved in wound healing; and as a bioactive component of an artificial skin, may have therapeutic value.

Original languageEnglish
Pages (from-to)1223-1227
Number of pages5
JournalPhytomedicine
Volume19
Issue number13
DOIs
Publication statusPublished - 2012 Oct 15

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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