Aspirin-intolerant asthma in the Korean population: Prevalence and characteristics based on a questionnaire survey

Ji Yong Moon, Sang Heon Kim, Tae Bum Kim, Sae Hoon Kim, Yoon Seok Chang, Jae Hyun Lee, You Sook Cho, Jung Won Park, An Soo Jang, Choon Sik Park, Dong Ho Nahm, Young Joo Cho, Sang Heon Cho, Byoung Whui Choi, Hee Bom Moon, Ho Joo Yoon

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Abstract

Background: Aspirin-intolerant asthma is a unique clinical syndrome characterized by acute bronchoconstriction following the administration of aspirin and/or non-steroidal anti-inflammatory drugs. Objective: We assessed the prevalence and investigated the demographic and clinical characteristics of adult patients with aspirin-intolerant asthma in Korea. Methods: Using an adult asthma cohort (COREA) from 11 university hospitals in Korea, we analyzed the prevalence of aspirin-intolerant asthma, defined as a positive response to the question: "Have you ever experienced dyspnea and cough after taking an aspirin or any NSAID (cold medicine)?" Demographic and clinical characteristics were compared between patients with aspirin-intolerant asthma and aspirin-tolerant asthma. Results: Aspirin-intolerant asthma was reported in 68 (5.8%) of 1173 adult asthmatics (age 15-84). Patients with aspirin-intolerant asthma had a lower mean age (43.9 ± 13.4 vs. 49.0 ± 15.6, P = 0.003) and a higher prevalence of rhinosinusitis (77.9% vs. 61.7%, P = 0.012) and atopic dermatitis (16.2% vs. 5.7%, P = 0.001) than aspirin-tolerant asthma patients. There were no significant differences in lung function, asthma severity or the use of asthma controllers. However, aspirin-intolerant asthma was associated with greater use of healthcare services over a lifetime and over the past 12 months. Aspirin-intolerant asthma was significantly associated with emergency room visits over the past 12 months (P = 0.029, OR 2.19, 95% CI 1.08-4.42). Conclusion: Based on histories, the prevalence of aspirin-intolerant asthma is 5.8% among adult asthma patients in Korea. Aspirin-intolerant asthma is associated with lower age, higher prevalence of rhinosinusitis and atopic dermatitis, and more frequent exacerbations.

Original languageEnglish
Pages (from-to)202-208
Number of pages7
JournalRespiratory Medicine
Volume107
Issue number2
DOIs
Publication statusPublished - 2013 Feb

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Population Characteristics
Aspirin
Asthma
Korea
Surveys and Questionnaires
Atopic Dermatitis
Demography
Bronchoconstriction
Non-Steroidal Anti-Inflammatory Agents
Cough
Dyspnea
Hospital Emergency Service

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Moon, J. Y., Kim, S. H., Kim, T. B., Kim, S. H., Chang, Y. S., Lee, J. H., ... Yoon, H. J. (2013). Aspirin-intolerant asthma in the Korean population: Prevalence and characteristics based on a questionnaire survey. Respiratory Medicine, 107(2), 202-208. https://doi.org/10.1016/j.rmed.2012.10.020
Moon, Ji Yong ; Kim, Sang Heon ; Kim, Tae Bum ; Kim, Sae Hoon ; Chang, Yoon Seok ; Lee, Jae Hyun ; Cho, You Sook ; Park, Jung Won ; Jang, An Soo ; Park, Choon Sik ; Nahm, Dong Ho ; Cho, Young Joo ; Cho, Sang Heon ; Choi, Byoung Whui ; Moon, Hee Bom ; Yoon, Ho Joo. / Aspirin-intolerant asthma in the Korean population : Prevalence and characteristics based on a questionnaire survey. In: Respiratory Medicine. 2013 ; Vol. 107, No. 2. pp. 202-208.
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abstract = "Background: Aspirin-intolerant asthma is a unique clinical syndrome characterized by acute bronchoconstriction following the administration of aspirin and/or non-steroidal anti-inflammatory drugs. Objective: We assessed the prevalence and investigated the demographic and clinical characteristics of adult patients with aspirin-intolerant asthma in Korea. Methods: Using an adult asthma cohort (COREA) from 11 university hospitals in Korea, we analyzed the prevalence of aspirin-intolerant asthma, defined as a positive response to the question: {"}Have you ever experienced dyspnea and cough after taking an aspirin or any NSAID (cold medicine)?{"} Demographic and clinical characteristics were compared between patients with aspirin-intolerant asthma and aspirin-tolerant asthma. Results: Aspirin-intolerant asthma was reported in 68 (5.8{\%}) of 1173 adult asthmatics (age 15-84). Patients with aspirin-intolerant asthma had a lower mean age (43.9 ± 13.4 vs. 49.0 ± 15.6, P = 0.003) and a higher prevalence of rhinosinusitis (77.9{\%} vs. 61.7{\%}, P = 0.012) and atopic dermatitis (16.2{\%} vs. 5.7{\%}, P = 0.001) than aspirin-tolerant asthma patients. There were no significant differences in lung function, asthma severity or the use of asthma controllers. However, aspirin-intolerant asthma was associated with greater use of healthcare services over a lifetime and over the past 12 months. Aspirin-intolerant asthma was significantly associated with emergency room visits over the past 12 months (P = 0.029, OR 2.19, 95{\%} CI 1.08-4.42). Conclusion: Based on histories, the prevalence of aspirin-intolerant asthma is 5.8{\%} among adult asthma patients in Korea. Aspirin-intolerant asthma is associated with lower age, higher prevalence of rhinosinusitis and atopic dermatitis, and more frequent exacerbations.",
author = "Moon, {Ji Yong} and Kim, {Sang Heon} and Kim, {Tae Bum} and Kim, {Sae Hoon} and Chang, {Yoon Seok} and Lee, {Jae Hyun} and Cho, {You Sook} and Park, {Jung Won} and Jang, {An Soo} and Park, {Choon Sik} and Nahm, {Dong Ho} and Cho, {Young Joo} and Cho, {Sang Heon} and Choi, {Byoung Whui} and Moon, {Hee Bom} and Yoon, {Ho Joo}",
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Moon, JY, Kim, SH, Kim, TB, Kim, SH, Chang, YS, Lee, JH, Cho, YS, Park, JW, Jang, AS, Park, CS, Nahm, DH, Cho, YJ, Cho, SH, Choi, BW, Moon, HB & Yoon, HJ 2013, 'Aspirin-intolerant asthma in the Korean population: Prevalence and characteristics based on a questionnaire survey', Respiratory Medicine, vol. 107, no. 2, pp. 202-208. https://doi.org/10.1016/j.rmed.2012.10.020

Aspirin-intolerant asthma in the Korean population : Prevalence and characteristics based on a questionnaire survey. / Moon, Ji Yong; Kim, Sang Heon; Kim, Tae Bum; Kim, Sae Hoon; Chang, Yoon Seok; Lee, Jae Hyun; Cho, You Sook; Park, Jung Won; Jang, An Soo; Park, Choon Sik; Nahm, Dong Ho; Cho, Young Joo; Cho, Sang Heon; Choi, Byoung Whui; Moon, Hee Bom; Yoon, Ho Joo.

In: Respiratory Medicine, Vol. 107, No. 2, 02.2013, p. 202-208.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Aspirin-intolerant asthma in the Korean population

T2 - Prevalence and characteristics based on a questionnaire survey

AU - Moon, Ji Yong

AU - Kim, Sang Heon

AU - Kim, Tae Bum

AU - Kim, Sae Hoon

AU - Chang, Yoon Seok

AU - Lee, Jae Hyun

AU - Cho, You Sook

AU - Park, Jung Won

AU - Jang, An Soo

AU - Park, Choon Sik

AU - Nahm, Dong Ho

AU - Cho, Young Joo

AU - Cho, Sang Heon

AU - Choi, Byoung Whui

AU - Moon, Hee Bom

AU - Yoon, Ho Joo

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N2 - Background: Aspirin-intolerant asthma is a unique clinical syndrome characterized by acute bronchoconstriction following the administration of aspirin and/or non-steroidal anti-inflammatory drugs. Objective: We assessed the prevalence and investigated the demographic and clinical characteristics of adult patients with aspirin-intolerant asthma in Korea. Methods: Using an adult asthma cohort (COREA) from 11 university hospitals in Korea, we analyzed the prevalence of aspirin-intolerant asthma, defined as a positive response to the question: "Have you ever experienced dyspnea and cough after taking an aspirin or any NSAID (cold medicine)?" Demographic and clinical characteristics were compared between patients with aspirin-intolerant asthma and aspirin-tolerant asthma. Results: Aspirin-intolerant asthma was reported in 68 (5.8%) of 1173 adult asthmatics (age 15-84). Patients with aspirin-intolerant asthma had a lower mean age (43.9 ± 13.4 vs. 49.0 ± 15.6, P = 0.003) and a higher prevalence of rhinosinusitis (77.9% vs. 61.7%, P = 0.012) and atopic dermatitis (16.2% vs. 5.7%, P = 0.001) than aspirin-tolerant asthma patients. There were no significant differences in lung function, asthma severity or the use of asthma controllers. However, aspirin-intolerant asthma was associated with greater use of healthcare services over a lifetime and over the past 12 months. Aspirin-intolerant asthma was significantly associated with emergency room visits over the past 12 months (P = 0.029, OR 2.19, 95% CI 1.08-4.42). Conclusion: Based on histories, the prevalence of aspirin-intolerant asthma is 5.8% among adult asthma patients in Korea. Aspirin-intolerant asthma is associated with lower age, higher prevalence of rhinosinusitis and atopic dermatitis, and more frequent exacerbations.

AB - Background: Aspirin-intolerant asthma is a unique clinical syndrome characterized by acute bronchoconstriction following the administration of aspirin and/or non-steroidal anti-inflammatory drugs. Objective: We assessed the prevalence and investigated the demographic and clinical characteristics of adult patients with aspirin-intolerant asthma in Korea. Methods: Using an adult asthma cohort (COREA) from 11 university hospitals in Korea, we analyzed the prevalence of aspirin-intolerant asthma, defined as a positive response to the question: "Have you ever experienced dyspnea and cough after taking an aspirin or any NSAID (cold medicine)?" Demographic and clinical characteristics were compared between patients with aspirin-intolerant asthma and aspirin-tolerant asthma. Results: Aspirin-intolerant asthma was reported in 68 (5.8%) of 1173 adult asthmatics (age 15-84). Patients with aspirin-intolerant asthma had a lower mean age (43.9 ± 13.4 vs. 49.0 ± 15.6, P = 0.003) and a higher prevalence of rhinosinusitis (77.9% vs. 61.7%, P = 0.012) and atopic dermatitis (16.2% vs. 5.7%, P = 0.001) than aspirin-tolerant asthma patients. There were no significant differences in lung function, asthma severity or the use of asthma controllers. However, aspirin-intolerant asthma was associated with greater use of healthcare services over a lifetime and over the past 12 months. Aspirin-intolerant asthma was significantly associated with emergency room visits over the past 12 months (P = 0.029, OR 2.19, 95% CI 1.08-4.42). Conclusion: Based on histories, the prevalence of aspirin-intolerant asthma is 5.8% among adult asthma patients in Korea. Aspirin-intolerant asthma is associated with lower age, higher prevalence of rhinosinusitis and atopic dermatitis, and more frequent exacerbations.

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