Assessment of chromosomal losses and gains in hepatocellular carcinoma

Joon Chang, Nam Gyun Kim, Zhe Piao, Chanil Park, Kang Sik Park, Young Ki Paik, Woo Jung Lee, Byong Ro Kim, Hoguen Kim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We examined the chromosomal changes of 22 hepatocellular carcinomas (HCCs) by comparative genomic hybridization (CGH) analysis and compared the results with that of allelotype by polymerase chain reaction based loss of heterozygosity (PCR-LOH) analysis. By CGH analysis, frequent chromosomal losses were noted in the chromosomal region of 4q (59%), 8p (77%), and 16q (50%), whereas gains were noted in 1q (86%) and 8q (77%). All of these chromosomal arms were revealed to have frequent allelic imbalances by PCR-LOH analysis, however, 9% of chromosomal aberrations were detected only by CGH analysis and 2% were detected only by PCR-LOH analysis. Our results suggest that CGH analysis gives more precise results for the screening of chromosomal aberrations in HCCs than that of PCR-LOH analysis with randomly selected microsatellite markers.

Original languageEnglish
Pages (from-to)193-202
Number of pages10
JournalCancer Letters
Volume182
Issue number2
DOIs
Publication statusPublished - 2002 Aug 28

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Chang, J., Kim, N. G., Piao, Z., Park, C., Park, K. S., Paik, Y. K., Lee, W. J., Kim, B. R., & Kim, H. (2002). Assessment of chromosomal losses and gains in hepatocellular carcinoma. Cancer Letters, 182(2), 193-202. https://doi.org/10.1016/S0304-3835(02)00083-6