Assessment of cognitive impairment in a mouse model of high-fat diet-induced metabolic stress with touchscreen-based automated battery system

Saeram Lee, Jong Youl Kim, Eosu Kim, KyoungYul Seo, Youn Jae Kang, Jae Young Kim, Chul Hoon Kim, Ho Taek Song, Lisa M. Saksida, Jongeun Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Obesity-related metabolic disorders can affect not only systemic health but also brain function. Recent studies have elucidated that amyloid beta deposition cannot satisfactorily explain the development of Alzheimer's disease (AD) and that dysregulation of glucose metabolism is a critical factor for the sporadic onset of non-genetic AD. Identifying the pathophysiology of AD due to changes in brain metabolism is crucial; however, it is limited in measuring changes in brain cognitive function due to metabolic changes in animal models. The touchscreen-based automated battery system, which is more accurate and less invasive than conventional behavioral test tools, is used to assess the cognition of mice with dysregulated metabolism. This system was introduced in humans to evaluate cognitive function and was recently back-translated in monkeys and rodents. We used outbred ICR mice fed on highfat diet (HFD) and performed the paired associates learning (PAL) test to detect their visual memory and new learning ability loss as well as to assess memory impairment. The behavioral performance of the HFD mice was weaker than that of normal mice in the training but was not significantly associated with motivation. In the PAL test, the average number of trials completed and proportion of correct touches was significantly lower in HFD mice than in normal diet-fed mice. Our results reveal that HFD-induced metabolic dysregulation has detrimental effects on operant learning according to the percentage of correct responses in PAL. These findings establish that HFD-induced metabolic stress may have an effect in accelerating AD-like pathogenesis.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalExperimental Neurobiology
Volume27
Issue number4
DOIs
Publication statusPublished - 2018 Aug 1

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Physiological Stress
High Fat Diet
Paired-Associate Learning
Diet
Alzheimer Disease
Cognition
Brain
Learning
Inbred ICR Mouse
Aptitude
Touch
Amyloid
Haplorhini
Cognitive Dysfunction
Motivation
Rodentia
Animal Models
Obesity
Glucose
Health

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Lee, Saeram ; Kim, Jong Youl ; Kim, Eosu ; Seo, KyoungYul ; Kang, Youn Jae ; Kim, Jae Young ; Kim, Chul Hoon ; Song, Ho Taek ; Saksida, Lisa M. ; Lee, Jongeun. / Assessment of cognitive impairment in a mouse model of high-fat diet-induced metabolic stress with touchscreen-based automated battery system. In: Experimental Neurobiology. 2018 ; Vol. 27, No. 4. pp. 277-286.
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Assessment of cognitive impairment in a mouse model of high-fat diet-induced metabolic stress with touchscreen-based automated battery system. / Lee, Saeram; Kim, Jong Youl; Kim, Eosu; Seo, KyoungYul; Kang, Youn Jae; Kim, Jae Young; Kim, Chul Hoon; Song, Ho Taek; Saksida, Lisa M.; Lee, Jongeun.

In: Experimental Neurobiology, Vol. 27, No. 4, 01.08.2018, p. 277-286.

Research output: Contribution to journalArticle

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