Assessment of extent and role of tau in subcortical vascular cognitive impairment using 18F-AV1451 positron emission tomography imaging

Hee Jin Kim, Seongbeom Park, Hanna Cho, Young Kyoung Jang, Jin San Lee, Hyemin Jang, Yeshin Kim, Ko Woon Kim, Young Hoon Ryu, Jae Yong Choi, Seung Hwan Moon, Michael W. Weiner, William J. Jagust, Gil D. Rabinovici, Charles DeCarli, Chul Hyoung Lyoo, Duk L. Na, Sang Won Seo

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Abstract

IMPORTANCE Amyloid-β (Aβ), tau, and cerebral small vessel disease (CSVD), which occasionally coexist, are the most common causes of cognitive impairments in older people. However, whether tau is observed in patients with subcortical vascular cognitive impairment (SVCI), as well as its associations with Aβ and CSVD, are not yet established. More importantly, the role of tau underlying cognitive impairments in SVCI is unknown. OBJECTIVE To investigate the extent and the role of tau in patients with SVCI using 18F-AV1451, which is a new ligand to detect neurofibrillary tangles in vivo. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study recruited 64 patients with SVCI from June 2015 to December 2016 at Samsung Medical Center, Seoul, Korea. The patients had significant ischemia on brain magnetic resonance imaging, defined as periventricular white matter hyperintensity at least 10mmand deep white matter hyperintensity at least 25 mm.We excluded 3 patients with SVCI owing to segmentation error during AV1451 positron emission tomography analysis. MAIN OUTCOMES AND MEASURES We calculated CSVD scores based on the volumes of white matter hyperintensities, numbers of lacunes, and microbleeds usingmagnetic resonance imaging data. The presence of Aβ was assessed using fluorine 18-labeled (18F) florbetaben positron emission tomography. Tau was measured using 18F-AV1451 positron emission tomography.We determined the spreading order of tau by sorting the regional frequencies of cortical involvement.We evaluated the complex associations between Aβ, CSVD, AV1451 uptake, and cognition in patients with SVCI. RESULTS Of the 61 patients with SVCI, 44 (72.1%) were women and the mean (SD) age was 78.7 (6.3) years. Patients with SVCI, especially patients with Aβ-negative SVCI, showed higher AV1451 uptake in the inferior temporal areas compared with normal control individuals. In patients with SVCI, Aβ positivity and CSVD score were each independently associated with increased AV1451 uptake in the medial temporal and inferior temporal regions, respectively. Involvement frequency of AV1451 uptake in the fusiform gyrus, inferior temporal, and precuneus regions were higher than that in the parahippocampal region. In patients with SVCI, higher AV1451 uptake in the inferior temporal and medial temporal regions correlated with worse language and general cognitive function. In patients with SVCI, Aβ positivity and CSVD score each correlated with worse general cognitive function, which was completely mediated by AV1451 uptake in the entorhinal cortex and inferior temporal gyrus, respectively. CONCLUSIONS AND RELEVANCE Our findings suggest that in SVCI, both Aβ and CSVD were independently associated with increased tau accumulation. Furthermore, tau burden played a pivotal role because it was the final common pathway for the cognitive impairment in patients with SVCI.

Original languageEnglish
Pages (from-to)999-1007
Number of pages9
JournalJAMA Neurology
Volume75
Issue number8
DOIs
Publication statusPublished - 2018 Aug

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Positron-Emission Tomography
Blood Vessels
Cerebral Small Vessel Diseases
Temporal Lobe
Cognition
Cognitive Dysfunction
Entorhinal Cortex
Parietal Lobe
Neurofibrillary Tangles
Fluorine
Korea
Brain Ischemia
Amyloid

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Kim, Hee Jin ; Park, Seongbeom ; Cho, Hanna ; Jang, Young Kyoung ; Lee, Jin San ; Jang, Hyemin ; Kim, Yeshin ; Kim, Ko Woon ; Ryu, Young Hoon ; Choi, Jae Yong ; Moon, Seung Hwan ; Weiner, Michael W. ; Jagust, William J. ; Rabinovici, Gil D. ; DeCarli, Charles ; Lyoo, Chul Hyoung ; Na, Duk L. ; Seo, Sang Won. / Assessment of extent and role of tau in subcortical vascular cognitive impairment using 18F-AV1451 positron emission tomography imaging. In: JAMA Neurology. 2018 ; Vol. 75, No. 8. pp. 999-1007.
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abstract = "IMPORTANCE Amyloid-β (Aβ), tau, and cerebral small vessel disease (CSVD), which occasionally coexist, are the most common causes of cognitive impairments in older people. However, whether tau is observed in patients with subcortical vascular cognitive impairment (SVCI), as well as its associations with Aβ and CSVD, are not yet established. More importantly, the role of tau underlying cognitive impairments in SVCI is unknown. OBJECTIVE To investigate the extent and the role of tau in patients with SVCI using 18F-AV1451, which is a new ligand to detect neurofibrillary tangles in vivo. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study recruited 64 patients with SVCI from June 2015 to December 2016 at Samsung Medical Center, Seoul, Korea. The patients had significant ischemia on brain magnetic resonance imaging, defined as periventricular white matter hyperintensity at least 10mmand deep white matter hyperintensity at least 25 mm.We excluded 3 patients with SVCI owing to segmentation error during AV1451 positron emission tomography analysis. MAIN OUTCOMES AND MEASURES We calculated CSVD scores based on the volumes of white matter hyperintensities, numbers of lacunes, and microbleeds usingmagnetic resonance imaging data. The presence of Aβ was assessed using fluorine 18-labeled (18F) florbetaben positron emission tomography. Tau was measured using 18F-AV1451 positron emission tomography.We determined the spreading order of tau by sorting the regional frequencies of cortical involvement.We evaluated the complex associations between Aβ, CSVD, AV1451 uptake, and cognition in patients with SVCI. RESULTS Of the 61 patients with SVCI, 44 (72.1{\%}) were women and the mean (SD) age was 78.7 (6.3) years. Patients with SVCI, especially patients with Aβ-negative SVCI, showed higher AV1451 uptake in the inferior temporal areas compared with normal control individuals. In patients with SVCI, Aβ positivity and CSVD score were each independently associated with increased AV1451 uptake in the medial temporal and inferior temporal regions, respectively. Involvement frequency of AV1451 uptake in the fusiform gyrus, inferior temporal, and precuneus regions were higher than that in the parahippocampal region. In patients with SVCI, higher AV1451 uptake in the inferior temporal and medial temporal regions correlated with worse language and general cognitive function. In patients with SVCI, Aβ positivity and CSVD score each correlated with worse general cognitive function, which was completely mediated by AV1451 uptake in the entorhinal cortex and inferior temporal gyrus, respectively. CONCLUSIONS AND RELEVANCE Our findings suggest that in SVCI, both Aβ and CSVD were independently associated with increased tau accumulation. Furthermore, tau burden played a pivotal role because it was the final common pathway for the cognitive impairment in patients with SVCI.",
author = "Kim, {Hee Jin} and Seongbeom Park and Hanna Cho and Jang, {Young Kyoung} and Lee, {Jin San} and Hyemin Jang and Yeshin Kim and Kim, {Ko Woon} and Ryu, {Young Hoon} and Choi, {Jae Yong} and Moon, {Seung Hwan} and Weiner, {Michael W.} and Jagust, {William J.} and Rabinovici, {Gil D.} and Charles DeCarli and Lyoo, {Chul Hyoung} and Na, {Duk L.} and Seo, {Sang Won}",
year = "2018",
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pages = "999--1007",
journal = "JAMA Neurology",
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Kim, HJ, Park, S, Cho, H, Jang, YK, Lee, JS, Jang, H, Kim, Y, Kim, KW, Ryu, YH, Choi, JY, Moon, SH, Weiner, MW, Jagust, WJ, Rabinovici, GD, DeCarli, C, Lyoo, CH, Na, DL & Seo, SW 2018, 'Assessment of extent and role of tau in subcortical vascular cognitive impairment using 18F-AV1451 positron emission tomography imaging', JAMA Neurology, vol. 75, no. 8, pp. 999-1007. https://doi.org/10.1001/jamaneurol.2018.0975

Assessment of extent and role of tau in subcortical vascular cognitive impairment using 18F-AV1451 positron emission tomography imaging. / Kim, Hee Jin; Park, Seongbeom; Cho, Hanna; Jang, Young Kyoung; Lee, Jin San; Jang, Hyemin; Kim, Yeshin; Kim, Ko Woon; Ryu, Young Hoon; Choi, Jae Yong; Moon, Seung Hwan; Weiner, Michael W.; Jagust, William J.; Rabinovici, Gil D.; DeCarli, Charles; Lyoo, Chul Hyoung; Na, Duk L.; Seo, Sang Won.

In: JAMA Neurology, Vol. 75, No. 8, 08.2018, p. 999-1007.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Assessment of extent and role of tau in subcortical vascular cognitive impairment using 18F-AV1451 positron emission tomography imaging

AU - Kim, Hee Jin

AU - Park, Seongbeom

AU - Cho, Hanna

AU - Jang, Young Kyoung

AU - Lee, Jin San

AU - Jang, Hyemin

AU - Kim, Yeshin

AU - Kim, Ko Woon

AU - Ryu, Young Hoon

AU - Choi, Jae Yong

AU - Moon, Seung Hwan

AU - Weiner, Michael W.

AU - Jagust, William J.

AU - Rabinovici, Gil D.

AU - DeCarli, Charles

AU - Lyoo, Chul Hyoung

AU - Na, Duk L.

AU - Seo, Sang Won

PY - 2018/8

Y1 - 2018/8

N2 - IMPORTANCE Amyloid-β (Aβ), tau, and cerebral small vessel disease (CSVD), which occasionally coexist, are the most common causes of cognitive impairments in older people. However, whether tau is observed in patients with subcortical vascular cognitive impairment (SVCI), as well as its associations with Aβ and CSVD, are not yet established. More importantly, the role of tau underlying cognitive impairments in SVCI is unknown. OBJECTIVE To investigate the extent and the role of tau in patients with SVCI using 18F-AV1451, which is a new ligand to detect neurofibrillary tangles in vivo. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study recruited 64 patients with SVCI from June 2015 to December 2016 at Samsung Medical Center, Seoul, Korea. The patients had significant ischemia on brain magnetic resonance imaging, defined as periventricular white matter hyperintensity at least 10mmand deep white matter hyperintensity at least 25 mm.We excluded 3 patients with SVCI owing to segmentation error during AV1451 positron emission tomography analysis. MAIN OUTCOMES AND MEASURES We calculated CSVD scores based on the volumes of white matter hyperintensities, numbers of lacunes, and microbleeds usingmagnetic resonance imaging data. The presence of Aβ was assessed using fluorine 18-labeled (18F) florbetaben positron emission tomography. Tau was measured using 18F-AV1451 positron emission tomography.We determined the spreading order of tau by sorting the regional frequencies of cortical involvement.We evaluated the complex associations between Aβ, CSVD, AV1451 uptake, and cognition in patients with SVCI. RESULTS Of the 61 patients with SVCI, 44 (72.1%) were women and the mean (SD) age was 78.7 (6.3) years. Patients with SVCI, especially patients with Aβ-negative SVCI, showed higher AV1451 uptake in the inferior temporal areas compared with normal control individuals. In patients with SVCI, Aβ positivity and CSVD score were each independently associated with increased AV1451 uptake in the medial temporal and inferior temporal regions, respectively. Involvement frequency of AV1451 uptake in the fusiform gyrus, inferior temporal, and precuneus regions were higher than that in the parahippocampal region. In patients with SVCI, higher AV1451 uptake in the inferior temporal and medial temporal regions correlated with worse language and general cognitive function. In patients with SVCI, Aβ positivity and CSVD score each correlated with worse general cognitive function, which was completely mediated by AV1451 uptake in the entorhinal cortex and inferior temporal gyrus, respectively. CONCLUSIONS AND RELEVANCE Our findings suggest that in SVCI, both Aβ and CSVD were independently associated with increased tau accumulation. Furthermore, tau burden played a pivotal role because it was the final common pathway for the cognitive impairment in patients with SVCI.

AB - IMPORTANCE Amyloid-β (Aβ), tau, and cerebral small vessel disease (CSVD), which occasionally coexist, are the most common causes of cognitive impairments in older people. However, whether tau is observed in patients with subcortical vascular cognitive impairment (SVCI), as well as its associations with Aβ and CSVD, are not yet established. More importantly, the role of tau underlying cognitive impairments in SVCI is unknown. OBJECTIVE To investigate the extent and the role of tau in patients with SVCI using 18F-AV1451, which is a new ligand to detect neurofibrillary tangles in vivo. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study recruited 64 patients with SVCI from June 2015 to December 2016 at Samsung Medical Center, Seoul, Korea. The patients had significant ischemia on brain magnetic resonance imaging, defined as periventricular white matter hyperintensity at least 10mmand deep white matter hyperintensity at least 25 mm.We excluded 3 patients with SVCI owing to segmentation error during AV1451 positron emission tomography analysis. MAIN OUTCOMES AND MEASURES We calculated CSVD scores based on the volumes of white matter hyperintensities, numbers of lacunes, and microbleeds usingmagnetic resonance imaging data. The presence of Aβ was assessed using fluorine 18-labeled (18F) florbetaben positron emission tomography. Tau was measured using 18F-AV1451 positron emission tomography.We determined the spreading order of tau by sorting the regional frequencies of cortical involvement.We evaluated the complex associations between Aβ, CSVD, AV1451 uptake, and cognition in patients with SVCI. RESULTS Of the 61 patients with SVCI, 44 (72.1%) were women and the mean (SD) age was 78.7 (6.3) years. Patients with SVCI, especially patients with Aβ-negative SVCI, showed higher AV1451 uptake in the inferior temporal areas compared with normal control individuals. In patients with SVCI, Aβ positivity and CSVD score were each independently associated with increased AV1451 uptake in the medial temporal and inferior temporal regions, respectively. Involvement frequency of AV1451 uptake in the fusiform gyrus, inferior temporal, and precuneus regions were higher than that in the parahippocampal region. In patients with SVCI, higher AV1451 uptake in the inferior temporal and medial temporal regions correlated with worse language and general cognitive function. In patients with SVCI, Aβ positivity and CSVD score each correlated with worse general cognitive function, which was completely mediated by AV1451 uptake in the entorhinal cortex and inferior temporal gyrus, respectively. CONCLUSIONS AND RELEVANCE Our findings suggest that in SVCI, both Aβ and CSVD were independently associated with increased tau accumulation. Furthermore, tau burden played a pivotal role because it was the final common pathway for the cognitive impairment in patients with SVCI.

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