Abstract
Importance: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. Background: To compare ocular surface parameters between post-refractive surgery patients and normal controls. Design: Cross-sectional single centre study. Participants: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients. Methods: Tear meniscus height, non-invasive keratographic tear film break-up time and meibography were measured using the Keratograph ® 5M. Fluorescein break-up time, ocular surface staining, examination of lid margins and meibomian glands, Schirmer's test and Ocular Surface Disease Index questionnaire were performed. Main Outcome Measures: Ordinary logistic regression was performed to evaluate the impact of clinical variables including refractive surgery on the meiboscores. Results: In post-LASIK patients, ocular surface parameters including Ocular Surface Disease Index scores, fluorescein break-up time and staining scores, except Schirmer's scores, were significantly worse than those in controls (P < 0.050). Ocular surface staining scores in post-LASEK/PRK patients was higher than that in the controls (P = 0.001). In post-refractive surgery patients, grade of meibomian gland parameters and meiboscores were worse than those of controls (all P < 0.050). Histories of refractive surgery were associated with high meiboscore (β = 1.100, P = 0.043 for LASIK and β = 1.039, P = 0.042 for LASEK/PRK). Conclusions and relevance: Corneal refractive surgery may adversely affect the ocular surface, and a reduction of functional meibomian glands can contribute to chronic tear film dysfunction after corneal refractive surgery.
| Original language | English |
|---|---|
| Pages (from-to) | 857-866 |
| Number of pages | 10 |
| Journal | Clinical and Experimental Ophthalmology |
| Volume | 45 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2017 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Ophthalmology
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Assessment of meibomian glands and tear film in post-refractive surgery patients. / Jung, Ji Won; Kim, Jung Yong; Chin, Hee Seung; Suh, Young Ju; Kim, Tae-im; Seo, KyoungYul.
In: Clinical and Experimental Ophthalmology, Vol. 45, No. 9, 01.12.2017, p. 857-866.Research output: Contribution to journal › Article
TY - JOUR
T1 - Assessment of meibomian glands and tear film in post-refractive surgery patients
AU - Jung, Ji Won
AU - Kim, Jung Yong
AU - Chin, Hee Seung
AU - Suh, Young Ju
AU - Kim, Tae-im
AU - Seo, KyoungYul
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Importance: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. Background: To compare ocular surface parameters between post-refractive surgery patients and normal controls. Design: Cross-sectional single centre study. Participants: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients. Methods: Tear meniscus height, non-invasive keratographic tear film break-up time and meibography were measured using the Keratograph ® 5M. Fluorescein break-up time, ocular surface staining, examination of lid margins and meibomian glands, Schirmer's test and Ocular Surface Disease Index questionnaire were performed. Main Outcome Measures: Ordinary logistic regression was performed to evaluate the impact of clinical variables including refractive surgery on the meiboscores. Results: In post-LASIK patients, ocular surface parameters including Ocular Surface Disease Index scores, fluorescein break-up time and staining scores, except Schirmer's scores, were significantly worse than those in controls (P < 0.050). Ocular surface staining scores in post-LASEK/PRK patients was higher than that in the controls (P = 0.001). In post-refractive surgery patients, grade of meibomian gland parameters and meiboscores were worse than those of controls (all P < 0.050). Histories of refractive surgery were associated with high meiboscore (β = 1.100, P = 0.043 for LASIK and β = 1.039, P = 0.042 for LASEK/PRK). Conclusions and relevance: Corneal refractive surgery may adversely affect the ocular surface, and a reduction of functional meibomian glands can contribute to chronic tear film dysfunction after corneal refractive surgery.
AB - Importance: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. Background: To compare ocular surface parameters between post-refractive surgery patients and normal controls. Design: Cross-sectional single centre study. Participants: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients. Methods: Tear meniscus height, non-invasive keratographic tear film break-up time and meibography were measured using the Keratograph ® 5M. Fluorescein break-up time, ocular surface staining, examination of lid margins and meibomian glands, Schirmer's test and Ocular Surface Disease Index questionnaire were performed. Main Outcome Measures: Ordinary logistic regression was performed to evaluate the impact of clinical variables including refractive surgery on the meiboscores. Results: In post-LASIK patients, ocular surface parameters including Ocular Surface Disease Index scores, fluorescein break-up time and staining scores, except Schirmer's scores, were significantly worse than those in controls (P < 0.050). Ocular surface staining scores in post-LASEK/PRK patients was higher than that in the controls (P = 0.001). In post-refractive surgery patients, grade of meibomian gland parameters and meiboscores were worse than those of controls (all P < 0.050). Histories of refractive surgery were associated with high meiboscore (β = 1.100, P = 0.043 for LASIK and β = 1.039, P = 0.042 for LASEK/PRK). Conclusions and relevance: Corneal refractive surgery may adversely affect the ocular surface, and a reduction of functional meibomian glands can contribute to chronic tear film dysfunction after corneal refractive surgery.
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U2 - 10.1111/ceo.12993
DO - 10.1111/ceo.12993
M3 - Article
VL - 45
SP - 857
EP - 866
JO - Clinical and Experimental Ophthalmology
JF - Clinical and Experimental Ophthalmology
SN - 1442-6404
IS - 9
ER -