Assessment of meibomian glands and tear film in post-refractive surgery patients

Ji Won Jung, Jung Yong Kim, Hee Seung Chin, Young Ju Suh, Tae-im Kim, KyoungYul Seo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Importance: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. Background: To compare ocular surface parameters between post-refractive surgery patients and normal controls. Design: Cross-sectional single centre study. Participants: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients. Methods: Tear meniscus height, non-invasive keratographic tear film break-up time and meibography were measured using the Keratograph ® 5M. Fluorescein break-up time, ocular surface staining, examination of lid margins and meibomian glands, Schirmer's test and Ocular Surface Disease Index questionnaire were performed. Main Outcome Measures: Ordinary logistic regression was performed to evaluate the impact of clinical variables including refractive surgery on the meiboscores. Results: In post-LASIK patients, ocular surface parameters including Ocular Surface Disease Index scores, fluorescein break-up time and staining scores, except Schirmer's scores, were significantly worse than those in controls (P < 0.050). Ocular surface staining scores in post-LASEK/PRK patients was higher than that in the controls (P = 0.001). In post-refractive surgery patients, grade of meibomian gland parameters and meiboscores were worse than those of controls (all P < 0.050). Histories of refractive surgery were associated with high meiboscore (β = 1.100, P = 0.043 for LASIK and β = 1.039, P = 0.042 for LASEK/PRK). Conclusions and relevance: Corneal refractive surgery may adversely affect the ocular surface, and a reduction of functional meibomian glands can contribute to chronic tear film dysfunction after corneal refractive surgery.

Original languageEnglish
Pages (from-to)857-866
Number of pages10
JournalClinical and Experimental Ophthalmology
Volume45
Issue number9
DOIs
Publication statusPublished - 2017 Dec 1

Fingerprint

Meibomian Glands
Refractive Surgical Procedures
Tears
Laser In Situ Keratomileusis
Lasers
Eye Diseases
Staining and Labeling
Fluorescein
Logistic Models
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Jung, Ji Won ; Kim, Jung Yong ; Chin, Hee Seung ; Suh, Young Ju ; Kim, Tae-im ; Seo, KyoungYul. / Assessment of meibomian glands and tear film in post-refractive surgery patients. In: Clinical and Experimental Ophthalmology. 2017 ; Vol. 45, No. 9. pp. 857-866.
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abstract = "Importance: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. Background: To compare ocular surface parameters between post-refractive surgery patients and normal controls. Design: Cross-sectional single centre study. Participants: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients. Methods: Tear meniscus height, non-invasive keratographic tear film break-up time and meibography were measured using the Keratograph {\circledR} 5M. Fluorescein break-up time, ocular surface staining, examination of lid margins and meibomian glands, Schirmer's test and Ocular Surface Disease Index questionnaire were performed. Main Outcome Measures: Ordinary logistic regression was performed to evaluate the impact of clinical variables including refractive surgery on the meiboscores. Results: In post-LASIK patients, ocular surface parameters including Ocular Surface Disease Index scores, fluorescein break-up time and staining scores, except Schirmer's scores, were significantly worse than those in controls (P < 0.050). Ocular surface staining scores in post-LASEK/PRK patients was higher than that in the controls (P = 0.001). In post-refractive surgery patients, grade of meibomian gland parameters and meiboscores were worse than those of controls (all P < 0.050). Histories of refractive surgery were associated with high meiboscore (β = 1.100, P = 0.043 for LASIK and β = 1.039, P = 0.042 for LASEK/PRK). Conclusions and relevance: Corneal refractive surgery may adversely affect the ocular surface, and a reduction of functional meibomian glands can contribute to chronic tear film dysfunction after corneal refractive surgery.",
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Assessment of meibomian glands and tear film in post-refractive surgery patients. / Jung, Ji Won; Kim, Jung Yong; Chin, Hee Seung; Suh, Young Ju; Kim, Tae-im; Seo, KyoungYul.

In: Clinical and Experimental Ophthalmology, Vol. 45, No. 9, 01.12.2017, p. 857-866.

Research output: Contribution to journalArticle

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T1 - Assessment of meibomian glands and tear film in post-refractive surgery patients

AU - Jung, Ji Won

AU - Kim, Jung Yong

AU - Chin, Hee Seung

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N2 - Importance: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. Background: To compare ocular surface parameters between post-refractive surgery patients and normal controls. Design: Cross-sectional single centre study. Participants: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients. Methods: Tear meniscus height, non-invasive keratographic tear film break-up time and meibography were measured using the Keratograph ® 5M. Fluorescein break-up time, ocular surface staining, examination of lid margins and meibomian glands, Schirmer's test and Ocular Surface Disease Index questionnaire were performed. Main Outcome Measures: Ordinary logistic regression was performed to evaluate the impact of clinical variables including refractive surgery on the meiboscores. Results: In post-LASIK patients, ocular surface parameters including Ocular Surface Disease Index scores, fluorescein break-up time and staining scores, except Schirmer's scores, were significantly worse than those in controls (P < 0.050). Ocular surface staining scores in post-LASEK/PRK patients was higher than that in the controls (P = 0.001). In post-refractive surgery patients, grade of meibomian gland parameters and meiboscores were worse than those of controls (all P < 0.050). Histories of refractive surgery were associated with high meiboscore (β = 1.100, P = 0.043 for LASIK and β = 1.039, P = 0.042 for LASEK/PRK). Conclusions and relevance: Corneal refractive surgery may adversely affect the ocular surface, and a reduction of functional meibomian glands can contribute to chronic tear film dysfunction after corneal refractive surgery.

AB - Importance: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. Background: To compare ocular surface parameters between post-refractive surgery patients and normal controls. Design: Cross-sectional single centre study. Participants: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients. Methods: Tear meniscus height, non-invasive keratographic tear film break-up time and meibography were measured using the Keratograph ® 5M. Fluorescein break-up time, ocular surface staining, examination of lid margins and meibomian glands, Schirmer's test and Ocular Surface Disease Index questionnaire were performed. Main Outcome Measures: Ordinary logistic regression was performed to evaluate the impact of clinical variables including refractive surgery on the meiboscores. Results: In post-LASIK patients, ocular surface parameters including Ocular Surface Disease Index scores, fluorescein break-up time and staining scores, except Schirmer's scores, were significantly worse than those in controls (P < 0.050). Ocular surface staining scores in post-LASEK/PRK patients was higher than that in the controls (P = 0.001). In post-refractive surgery patients, grade of meibomian gland parameters and meiboscores were worse than those of controls (all P < 0.050). Histories of refractive surgery were associated with high meiboscore (β = 1.100, P = 0.043 for LASIK and β = 1.039, P = 0.042 for LASEK/PRK). Conclusions and relevance: Corneal refractive surgery may adversely affect the ocular surface, and a reduction of functional meibomian glands can contribute to chronic tear film dysfunction after corneal refractive surgery.

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