Assessment of myocardial metaiodobenzylguanidine uptake and its relation to left ventricular systolic and diastolic functional parameters in dilated cardiomyopathy

Jong Won Ha, Jong Doo Lee, Namsik Chung, Yangsoo Jang, Sang Ho Cho, Byung Soo Kim, Se Joong Rim, Won Heum Shim, Seung Yun Cho, Sung Soon Kim

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to assess the relation between myocardial metaiodobenzylguanidine (MIBG) uptake and left ventricular systolic and diastolic functional parameters, both of which are known as predictors of prognosis in patients with dilated cardiomyopathy. Echocardiography and iodine-123-MIBG myocardial scintigraphy were performed in 35 patients of dilated cardiomyopathy with normal sinus rhythm. Mean myocardial MIBG uptake in the patient group at early and delayed images were significantly lower than those in normal control subjects (10.6±1.1, 9.8±1.2 vs 12.4±1.0, 12.1±1.0, p<0.01). There were, however, no significant differences of mean MIBG uptake in the lung and mediastinum between the two groups (p>0.05). There were no significant correlations between myocardial MIBG uptake, expressed as the ratio of heart/mediastinum MIBG activity at delayed image, and left ventricular systolic and diastolic functional parameters {left ventricular ejection fraction, left ventricular end-diastolic dimension, peak velocity of early diastolic filling (E velocity), deceleration time of E wave, cardiac output, left ventricular end-diastolic pressure}. In conclusion, the myocardial uptake of MIBG is decreased in patients with dilated cardiomyopathy assessed by iodine-123-MIBG myocardial scintigraphy. There were, however, no significant correlations between myocardial MIBG uptake and left ventricular systolic and diastolic functional parameters derived from echocardiography.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalYonsei medical journal
Volume40
Issue number3
DOIs
Publication statusPublished - 1999 Jun

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Dilated Cardiomyopathy
Myocardial Perfusion Imaging
Iodine
Echocardiography
Deceleration
Mediastinum
Cardiac Output
Stroke Volume
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ha, Jong Won ; Lee, Jong Doo ; Chung, Namsik ; Jang, Yangsoo ; Cho, Sang Ho ; Kim, Byung Soo ; Rim, Se Joong ; Shim, Won Heum ; Cho, Seung Yun ; Kim, Sung Soon. / Assessment of myocardial metaiodobenzylguanidine uptake and its relation to left ventricular systolic and diastolic functional parameters in dilated cardiomyopathy. In: Yonsei medical journal. 1999 ; Vol. 40, No. 3. pp. 199-206.
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abstract = "The purpose of this study was to assess the relation between myocardial metaiodobenzylguanidine (MIBG) uptake and left ventricular systolic and diastolic functional parameters, both of which are known as predictors of prognosis in patients with dilated cardiomyopathy. Echocardiography and iodine-123-MIBG myocardial scintigraphy were performed in 35 patients of dilated cardiomyopathy with normal sinus rhythm. Mean myocardial MIBG uptake in the patient group at early and delayed images were significantly lower than those in normal control subjects (10.6±1.1, 9.8±1.2 vs 12.4±1.0, 12.1±1.0, p<0.01). There were, however, no significant differences of mean MIBG uptake in the lung and mediastinum between the two groups (p>0.05). There were no significant correlations between myocardial MIBG uptake, expressed as the ratio of heart/mediastinum MIBG activity at delayed image, and left ventricular systolic and diastolic functional parameters {left ventricular ejection fraction, left ventricular end-diastolic dimension, peak velocity of early diastolic filling (E velocity), deceleration time of E wave, cardiac output, left ventricular end-diastolic pressure}. In conclusion, the myocardial uptake of MIBG is decreased in patients with dilated cardiomyopathy assessed by iodine-123-MIBG myocardial scintigraphy. There were, however, no significant correlations between myocardial MIBG uptake and left ventricular systolic and diastolic functional parameters derived from echocardiography.",
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Assessment of myocardial metaiodobenzylguanidine uptake and its relation to left ventricular systolic and diastolic functional parameters in dilated cardiomyopathy. / Ha, Jong Won; Lee, Jong Doo; Chung, Namsik; Jang, Yangsoo; Cho, Sang Ho; Kim, Byung Soo; Rim, Se Joong; Shim, Won Heum; Cho, Seung Yun; Kim, Sung Soon.

In: Yonsei medical journal, Vol. 40, No. 3, 06.1999, p. 199-206.

Research output: Contribution to journalArticle

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T1 - Assessment of myocardial metaiodobenzylguanidine uptake and its relation to left ventricular systolic and diastolic functional parameters in dilated cardiomyopathy

AU - Ha, Jong Won

AU - Lee, Jong Doo

AU - Chung, Namsik

AU - Jang, Yangsoo

AU - Cho, Sang Ho

AU - Kim, Byung Soo

AU - Rim, Se Joong

AU - Shim, Won Heum

AU - Cho, Seung Yun

AU - Kim, Sung Soon

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N2 - The purpose of this study was to assess the relation between myocardial metaiodobenzylguanidine (MIBG) uptake and left ventricular systolic and diastolic functional parameters, both of which are known as predictors of prognosis in patients with dilated cardiomyopathy. Echocardiography and iodine-123-MIBG myocardial scintigraphy were performed in 35 patients of dilated cardiomyopathy with normal sinus rhythm. Mean myocardial MIBG uptake in the patient group at early and delayed images were significantly lower than those in normal control subjects (10.6±1.1, 9.8±1.2 vs 12.4±1.0, 12.1±1.0, p<0.01). There were, however, no significant differences of mean MIBG uptake in the lung and mediastinum between the two groups (p>0.05). There were no significant correlations between myocardial MIBG uptake, expressed as the ratio of heart/mediastinum MIBG activity at delayed image, and left ventricular systolic and diastolic functional parameters {left ventricular ejection fraction, left ventricular end-diastolic dimension, peak velocity of early diastolic filling (E velocity), deceleration time of E wave, cardiac output, left ventricular end-diastolic pressure}. In conclusion, the myocardial uptake of MIBG is decreased in patients with dilated cardiomyopathy assessed by iodine-123-MIBG myocardial scintigraphy. There were, however, no significant correlations between myocardial MIBG uptake and left ventricular systolic and diastolic functional parameters derived from echocardiography.

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