Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy

Jong Doo Lee, Hae Jeong Park, Eun Sook Park, Dong Goo Kim, Dong Wook Rha, Eung Yeop Kim, Dong Ik Kim, Jae Jin Kim, Mijin Yun, Young Hoon Ryu, Jinu Lee, Jae Min Jeong, Dong Soo Lee, Myung Chul Lee, Chang Il Park

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Abstract

Periventricular leukomalacia (PVL) due to hypoxic-ischemic insult to the immature brain, chorioamnionitis and maternal infection are the major etiological factors of spastic type cerebral palsy (CP). Despite advances in preventing and treating certain causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric acid (GABA) receptor PET imaging using [18F]-fluoroflumazenil showed increased GABAA receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients (n = 20) compared with normal controls (n = 10). As GABAA receptor signaling modulates biological perception and production of movement, complex motor skills and use-dependent plasticity in the motor cortex, increased GABAA receptor binding in the motor cortex might play a important role in poor motor control. Decreased GABAA receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalNeuroImage
Volume34
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Lee, J. D., Park, H. J., Park, E. S., Kim, D. G., Rha, D. W., Kim, E. Y., Kim, D. I., Kim, J. J., Yun, M., Ryu, Y. H., Lee, J., Jeong, J. M., Lee, D. S., Lee, M. C., & Park, C. I. (2007). Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy. NeuroImage, 34(1), 19-25. https://doi.org/10.1016/j.neuroimage.2006.09.004