Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy

Jong Doo Lee, Hae Jeong Park, Eun Sook Park, Dong Goo Kim, Dong Wook Rha, Eung Yeop Kim, Dong Ik Kim, Jae Jin Kim, Mijin Yun, Young Hoon Ryu, Jinu Lee, Jae Min Jeong, Dong Soo Lee, Myung Chul Lee, Chang Il Park

Research output: Contribution to journalArticle

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Abstract

Periventricular leukomalacia (PVL) due to hypoxic-ischemic insult to the immature brain, chorioamnionitis and maternal infection are the major etiological factors of spastic type cerebral palsy (CP). Despite advances in preventing and treating certain causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric acid (GABA) receptor PET imaging using [18F]-fluoroflumazenil showed increased GABAA receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients (n = 20) compared with normal controls (n = 10). As GABAA receptor signaling modulates biological perception and production of movement, complex motor skills and use-dependent plasticity in the motor cortex, increased GABAA receptor binding in the motor cortex might play a important role in poor motor control. Decreased GABAA receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalNeuroImage
Volume34
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1

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GABA-A Receptors
Cerebral Palsy
Positron-Emission Tomography
Motor Cortex
Periventricular Leukomalacia
Chorioamnionitis
Motor Skills
GABA Receptors
Muscle Spasticity
Visual Cortex
Brain Stem
Mothers
Brain
Infection
Cerebral palsy, spastic, diplegic

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Lee, Jong Doo ; Park, Hae Jeong ; Park, Eun Sook ; Kim, Dong Goo ; Rha, Dong Wook ; Kim, Eung Yeop ; Kim, Dong Ik ; Kim, Jae Jin ; Yun, Mijin ; Ryu, Young Hoon ; Lee, Jinu ; Jeong, Jae Min ; Lee, Dong Soo ; Lee, Myung Chul ; Park, Chang Il. / Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy. In: NeuroImage. 2007 ; Vol. 34, No. 1. pp. 19-25.
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title = "Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy",
abstract = "Periventricular leukomalacia (PVL) due to hypoxic-ischemic insult to the immature brain, chorioamnionitis and maternal infection are the major etiological factors of spastic type cerebral palsy (CP). Despite advances in preventing and treating certain causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric acid (GABA) receptor PET imaging using [18F]-fluoroflumazenil showed increased GABAA receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients (n = 20) compared with normal controls (n = 10). As GABAA receptor signaling modulates biological perception and production of movement, complex motor skills and use-dependent plasticity in the motor cortex, increased GABAA receptor binding in the motor cortex might play a important role in poor motor control. Decreased GABAA receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom.",
author = "Lee, {Jong Doo} and Park, {Hae Jeong} and Park, {Eun Sook} and Kim, {Dong Goo} and Rha, {Dong Wook} and Kim, {Eung Yeop} and Kim, {Dong Ik} and Kim, {Jae Jin} and Mijin Yun and Ryu, {Young Hoon} and Jinu Lee and Jeong, {Jae Min} and Lee, {Dong Soo} and Lee, {Myung Chul} and Park, {Chang Il}",
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Lee, JD, Park, HJ, Park, ES, Kim, DG, Rha, DW, Kim, EY, Kim, DI, Kim, JJ, Yun, M, Ryu, YH, Lee, J, Jeong, JM, Lee, DS, Lee, MC & Park, CI 2007, 'Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy', NeuroImage, vol. 34, no. 1, pp. 19-25. https://doi.org/10.1016/j.neuroimage.2006.09.004

Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy. / Lee, Jong Doo; Park, Hae Jeong; Park, Eun Sook; Kim, Dong Goo; Rha, Dong Wook; Kim, Eung Yeop; Kim, Dong Ik; Kim, Jae Jin; Yun, Mijin; Ryu, Young Hoon; Lee, Jinu; Jeong, Jae Min; Lee, Dong Soo; Lee, Myung Chul; Park, Chang Il.

In: NeuroImage, Vol. 34, No. 1, 01.01.2007, p. 19-25.

Research output: Contribution to journalArticle

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T1 - Assessment of regional GABAA receptor binding using 18F-fluoroflumazenil positron emission tomography in spastic type cerebral palsy

AU - Lee, Jong Doo

AU - Park, Hae Jeong

AU - Park, Eun Sook

AU - Kim, Dong Goo

AU - Rha, Dong Wook

AU - Kim, Eung Yeop

AU - Kim, Dong Ik

AU - Kim, Jae Jin

AU - Yun, Mijin

AU - Ryu, Young Hoon

AU - Lee, Jinu

AU - Jeong, Jae Min

AU - Lee, Dong Soo

AU - Lee, Myung Chul

AU - Park, Chang Il

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Periventricular leukomalacia (PVL) due to hypoxic-ischemic insult to the immature brain, chorioamnionitis and maternal infection are the major etiological factors of spastic type cerebral palsy (CP). Despite advances in preventing and treating certain causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric acid (GABA) receptor PET imaging using [18F]-fluoroflumazenil showed increased GABAA receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients (n = 20) compared with normal controls (n = 10). As GABAA receptor signaling modulates biological perception and production of movement, complex motor skills and use-dependent plasticity in the motor cortex, increased GABAA receptor binding in the motor cortex might play a important role in poor motor control. Decreased GABAA receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom.

AB - Periventricular leukomalacia (PVL) due to hypoxic-ischemic insult to the immature brain, chorioamnionitis and maternal infection are the major etiological factors of spastic type cerebral palsy (CP). Despite advances in preventing and treating certain causes of CP, the number of patients has remained essentially unchanged and the pathophysiological mechanisms related to motor dysfunction remain poorly understood. In this study, statistical parametric mapping (SPM) analysis of cerebral gamma-aminobutyric acid (GABA) receptor PET imaging using [18F]-fluoroflumazenil showed increased GABAA receptor binding in the bilateral motor and visual cortices in spastic diplegia (SD) type CP patients (n = 20) compared with normal controls (n = 10). As GABAA receptor signaling modulates biological perception and production of movement, complex motor skills and use-dependent plasticity in the motor cortex, increased GABAA receptor binding in the motor cortex might play a important role in poor motor control. Decreased GABAA receptor binding was seen in the brain stem in SD CP patients, which appears to be related to spastic symptom.

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