TY - JOUR
T1 - Assessment of scoring systems for acute-on-chronic liver failure at predicting short-Term mortality in patients with
AU - Kim, Hee Yeon
AU - Kim, Chang Wook
AU - Kim, Tae Yeob
AU - Song, Do Seon
AU - Sinn, Dong Hyun
AU - Yoon, Eileen L.
AU - Jung, Young Kul
AU - Suk, Ki Tae
AU - Lee, Sang Soo
AU - Lee, Chang Hyeong
AU - Kim, Tae Hun
AU - Kim, Jeong Han
AU - Yim, Hyung Joon
AU - Kim, Sung Eun
AU - Baik, Soon Koo
AU - Lee, Byung Seok
AU - Jang, Jae Young
AU - Kim, Young Seok
AU - Kim, Sang Gyune
AU - Yang, Jin Mo
AU - Sohn, Joo Hyun
AU - Lee, Heon Ju
AU - Park, Seung Ha
AU - Choi, Eun Hee
AU - Kim, Dong Joon
N1 - Publisher Copyright:
© 2016 Baishideng Publishing Group Inc. All rights reserved.
PY - 2016/11/7
Y1 - 2016/11/7
N2 - AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis. METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-Term mortality was calculated for Chronic Liver Failure- Sequential Organ Failure Assessment (CLIF-SOFA), CLIF Consortium Organ Failure score (CLIF-C OFs), Maddrey's discriminant function (DF), age, bilirubin, international normalized ratio and creatinine score (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), model for end-stage liver disease (MELD), and MELD-Na. RESULTS Of 264 patients, 32 (12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86 (0.81-0.90), 0.89 (0.84-0.92), 0.79 (0.74-0.84), 0.78 (0.72-0.83), 0.81 (0.76-0.86), 0.83 (0.78-0.88), and 0.83 (0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality. CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-Term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.
AB - AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis. METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-Term mortality was calculated for Chronic Liver Failure- Sequential Organ Failure Assessment (CLIF-SOFA), CLIF Consortium Organ Failure score (CLIF-C OFs), Maddrey's discriminant function (DF), age, bilirubin, international normalized ratio and creatinine score (ABIC), Glasgow Alcoholic Hepatitis Score (GAHS), model for end-stage liver disease (MELD), and MELD-Na. RESULTS Of 264 patients, 32 (12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86 (0.81-0.90), 0.89 (0.84-0.92), 0.79 (0.74-0.84), 0.78 (0.72-0.83), 0.81 (0.76-0.86), 0.83 (0.78-0.88), and 0.83 (0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality. CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-Term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis.
UR - http://www.scopus.com/inward/record.url?scp=84995480794&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84995480794&partnerID=8YFLogxK
U2 - 10.3748/wjg.v22.i41.9205
DO - 10.3748/wjg.v22.i41.9205
M3 - Article
C2 - 27895407
AN - SCOPUS:84995480794
VL - 22
SP - 9205
EP - 9213
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 41
ER -