Assessment of tissue characteristics of noncalcified coronary plaques by 64-slice computed tomography in comparison with integrated backscatter intravascular ultrasound

Woo In Yang, Jin Hur, Young Guk Ko, Byung Wook Choi, Jung Sun Kim, Donghoon Choi, Jong Won Ha, Meonong Ki Hong, Yangsoo Jang, Namsik Chung, Won Heum Shim, Seung Yun Cho

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Background: The ability of 64-slice computed tomography (CT) angiography to differentiate plaque types remains unclear. We evaluated whether the density of noncalcified coronary plaques by 64-slice CT angiography correlates with plaque components assessed by integrated backscatter intravascular ultrasound (IB-IVUS). Methods: Eighty-six patients [stable angina/acute coronary syndrome (ACS) 67/19, mean age 62±11 years] who showed significant coronary artery stenosis (≥ 50% diameter stenosis) by 64-slice CT angiography underwent coronary angiography and were evaluated using IB-IVUS. Results: A total of 92 noncalcified coronary plaques on CT angiography were evaluated with IB-IVUS. There was a positive correlation between CT density and calcified tissue content (r=0.41, P<0.001). However, the CT density of plaques did not correlate with other tissue components. Patients with ACS showed more lipid (43.1±13.2 vs. 35.8±13.5, P=0.03) and less soft fibrous tissue (50.5±11.7 vs. 56.5±12.0, P=0.05) by IB-IVUS than those with stable angina. However, the mean CT density of plaques in ACS was not different from that in stable angina (140.6±88.5 vs. 113.1±80.9, P=0.19). Conclusion: Except for calcified tissue, CT angiography failed to differentiate plaque types of noncalcified tissue. Therefore, the role of 64-slice CT angiography in identifying lipid-rich plaques remains limited.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalCoronary artery disease
Issue number3
Publication statusPublished - 2010 May 1


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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