Assessment of total/specific IgE levels against 7 inhalant allergens in children aged 3 to 6 years in seoul, Korea

Eun Jin Kim, Ji Won Kwon, Yeon Mi Lim, Yoon Dankyu, Joo Hee Seo, Woo Sung Chang, Hyung Young Hyung, Jungwon Park, Sang Heon Sang, Soo Jong Hong, Joo Shi Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: Childhood allergies are a serious problem, as they may lead to lifetime chronic disease. Determination of total and specific IgE levels is known to be a diagnostic tool for allergic sensitization; however, IgE levels are affected by various factors, such as age, sex, ethnicity, and geographic area. Thus, we evaluated the distribution of total and specific serum IgE levels against seven inhalant allergens in preschool children and examined their association with allergic diseases in Seoul, Korea. Methods: Total/specific serum IgE determination and skin prick tests for seven common allergens were performed on 509 children aged 3 to 6 years from 16 child care centers in Seoul, Korea. Demographic characteristics were surveyed from parents using a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. A diagnosis of atopic dermatitis was made by physicians. Results: The geometric mean of total IgE was 80.48±3.80 kU/L in preschool children. IgE levels were higher in boys (boys, 102.34±3.52 kU/L; girls, 62.37±3.93 kU/L; P<0.001) and atopic subjects (atopic, 158.00±3.35 kU/L; non-atopic, 52.75±3.44 kU/L; P<0.001). An increased prevalence of atopy was associated with a high monthly household income (P=0.004) and higher maternal education level (above university-level education; P=0.009), as well as increased total IgE levels (P=0.036). Physician-diagnosed atopic dermatitis was associated with sensitization to inhalant allergens. Conclusions: Total IgE levels were very high as compared with those in previous reports from other countries. The most common sensitized allergen was Dermatophagoides farinae, and the positive response rate peaked at age 3 years and was maintained thereafter, particularly in boys. Specific IgE levels for seven inhalant allergens varied with age in preschool children. Although further investigations are needed with a broad range of ages and various allergens, the distribution of the total and specific serum IgE levels in preschool children might help to serve as a reference value to diagnose atopy.

Original languageEnglish
Pages (from-to)162-169
Number of pages8
JournalAllergy, Asthma and Immunology Research
Volume5
Issue number3
DOIs
Publication statusPublished - 2013 May 1

Fingerprint

Korea
Allergens
Immunoglobulin E
Preschool Children
Atopic Dermatitis
Hypersensitivity
Serum
Seoul
Dermatophagoides Antigens
Physicians
Education
Child Care
Skin Tests
Reference Values
Chronic Disease
Asthma
Parents
Mothers
Demography

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Kim, Eun Jin ; Kwon, Ji Won ; Lim, Yeon Mi ; Dankyu, Yoon ; Seo, Joo Hee ; Chang, Woo Sung ; Hyung, Hyung Young ; Park, Jungwon ; Sang, Sang Heon ; Hong, Soo Jong ; Lee, Joo Shi. / Assessment of total/specific IgE levels against 7 inhalant allergens in children aged 3 to 6 years in seoul, Korea. In: Allergy, Asthma and Immunology Research. 2013 ; Vol. 5, No. 3. pp. 162-169.
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abstract = "Purpose: Childhood allergies are a serious problem, as they may lead to lifetime chronic disease. Determination of total and specific IgE levels is known to be a diagnostic tool for allergic sensitization; however, IgE levels are affected by various factors, such as age, sex, ethnicity, and geographic area. Thus, we evaluated the distribution of total and specific serum IgE levels against seven inhalant allergens in preschool children and examined their association with allergic diseases in Seoul, Korea. Methods: Total/specific serum IgE determination and skin prick tests for seven common allergens were performed on 509 children aged 3 to 6 years from 16 child care centers in Seoul, Korea. Demographic characteristics were surveyed from parents using a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. A diagnosis of atopic dermatitis was made by physicians. Results: The geometric mean of total IgE was 80.48±3.80 kU/L in preschool children. IgE levels were higher in boys (boys, 102.34±3.52 kU/L; girls, 62.37±3.93 kU/L; P<0.001) and atopic subjects (atopic, 158.00±3.35 kU/L; non-atopic, 52.75±3.44 kU/L; P<0.001). An increased prevalence of atopy was associated with a high monthly household income (P=0.004) and higher maternal education level (above university-level education; P=0.009), as well as increased total IgE levels (P=0.036). Physician-diagnosed atopic dermatitis was associated with sensitization to inhalant allergens. Conclusions: Total IgE levels were very high as compared with those in previous reports from other countries. The most common sensitized allergen was Dermatophagoides farinae, and the positive response rate peaked at age 3 years and was maintained thereafter, particularly in boys. Specific IgE levels for seven inhalant allergens varied with age in preschool children. Although further investigations are needed with a broad range of ages and various allergens, the distribution of the total and specific serum IgE levels in preschool children might help to serve as a reference value to diagnose atopy.",
author = "Kim, {Eun Jin} and Kwon, {Ji Won} and Lim, {Yeon Mi} and Yoon Dankyu and Seo, {Joo Hee} and Chang, {Woo Sung} and Hyung, {Hyung Young} and Jungwon Park and Sang, {Sang Heon} and Hong, {Soo Jong} and Lee, {Joo Shi}",
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Kim, EJ, Kwon, JW, Lim, YM, Dankyu, Y, Seo, JH, Chang, WS, Hyung, HY, Park, J, Sang, SH, Hong, SJ & Lee, JS 2013, 'Assessment of total/specific IgE levels against 7 inhalant allergens in children aged 3 to 6 years in seoul, Korea', Allergy, Asthma and Immunology Research, vol. 5, no. 3, pp. 162-169. https://doi.org/10.4168/aair.2013.5.3.162

Assessment of total/specific IgE levels against 7 inhalant allergens in children aged 3 to 6 years in seoul, Korea. / Kim, Eun Jin; Kwon, Ji Won; Lim, Yeon Mi; Dankyu, Yoon; Seo, Joo Hee; Chang, Woo Sung; Hyung, Hyung Young; Park, Jungwon; Sang, Sang Heon; Hong, Soo Jong; Lee, Joo Shi.

In: Allergy, Asthma and Immunology Research, Vol. 5, No. 3, 01.05.2013, p. 162-169.

Research output: Contribution to journalArticle

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T1 - Assessment of total/specific IgE levels against 7 inhalant allergens in children aged 3 to 6 years in seoul, Korea

AU - Kim, Eun Jin

AU - Kwon, Ji Won

AU - Lim, Yeon Mi

AU - Dankyu, Yoon

AU - Seo, Joo Hee

AU - Chang, Woo Sung

AU - Hyung, Hyung Young

AU - Park, Jungwon

AU - Sang, Sang Heon

AU - Hong, Soo Jong

AU - Lee, Joo Shi

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Purpose: Childhood allergies are a serious problem, as they may lead to lifetime chronic disease. Determination of total and specific IgE levels is known to be a diagnostic tool for allergic sensitization; however, IgE levels are affected by various factors, such as age, sex, ethnicity, and geographic area. Thus, we evaluated the distribution of total and specific serum IgE levels against seven inhalant allergens in preschool children and examined their association with allergic diseases in Seoul, Korea. Methods: Total/specific serum IgE determination and skin prick tests for seven common allergens were performed on 509 children aged 3 to 6 years from 16 child care centers in Seoul, Korea. Demographic characteristics were surveyed from parents using a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. A diagnosis of atopic dermatitis was made by physicians. Results: The geometric mean of total IgE was 80.48±3.80 kU/L in preschool children. IgE levels were higher in boys (boys, 102.34±3.52 kU/L; girls, 62.37±3.93 kU/L; P<0.001) and atopic subjects (atopic, 158.00±3.35 kU/L; non-atopic, 52.75±3.44 kU/L; P<0.001). An increased prevalence of atopy was associated with a high monthly household income (P=0.004) and higher maternal education level (above university-level education; P=0.009), as well as increased total IgE levels (P=0.036). Physician-diagnosed atopic dermatitis was associated with sensitization to inhalant allergens. Conclusions: Total IgE levels were very high as compared with those in previous reports from other countries. The most common sensitized allergen was Dermatophagoides farinae, and the positive response rate peaked at age 3 years and was maintained thereafter, particularly in boys. Specific IgE levels for seven inhalant allergens varied with age in preschool children. Although further investigations are needed with a broad range of ages and various allergens, the distribution of the total and specific serum IgE levels in preschool children might help to serve as a reference value to diagnose atopy.

AB - Purpose: Childhood allergies are a serious problem, as they may lead to lifetime chronic disease. Determination of total and specific IgE levels is known to be a diagnostic tool for allergic sensitization; however, IgE levels are affected by various factors, such as age, sex, ethnicity, and geographic area. Thus, we evaluated the distribution of total and specific serum IgE levels against seven inhalant allergens in preschool children and examined their association with allergic diseases in Seoul, Korea. Methods: Total/specific serum IgE determination and skin prick tests for seven common allergens were performed on 509 children aged 3 to 6 years from 16 child care centers in Seoul, Korea. Demographic characteristics were surveyed from parents using a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. A diagnosis of atopic dermatitis was made by physicians. Results: The geometric mean of total IgE was 80.48±3.80 kU/L in preschool children. IgE levels were higher in boys (boys, 102.34±3.52 kU/L; girls, 62.37±3.93 kU/L; P<0.001) and atopic subjects (atopic, 158.00±3.35 kU/L; non-atopic, 52.75±3.44 kU/L; P<0.001). An increased prevalence of atopy was associated with a high monthly household income (P=0.004) and higher maternal education level (above university-level education; P=0.009), as well as increased total IgE levels (P=0.036). Physician-diagnosed atopic dermatitis was associated with sensitization to inhalant allergens. Conclusions: Total IgE levels were very high as compared with those in previous reports from other countries. The most common sensitized allergen was Dermatophagoides farinae, and the positive response rate peaked at age 3 years and was maintained thereafter, particularly in boys. Specific IgE levels for seven inhalant allergens varied with age in preschool children. Although further investigations are needed with a broad range of ages and various allergens, the distribution of the total and specific serum IgE levels in preschool children might help to serve as a reference value to diagnose atopy.

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