Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population

Suhg Namgoong, Hyun Sub Cheong, Jeong Hyun Kim, Lyoung Hyo Kim, Jung Yeon Seo, Seok-Gu Kang, Seon Jin Yoon, SeHoon Kim, Jong Hee Chang, Hyoung Doo Shin

Research output: Contribution to journalArticle

Abstract

Previous studies have identified multiple loci for inherited susceptibility to glioma development, including the regulator of telomere elongation helicase 1 (RTEL1). However, the association between RTEL1 variants and risk of glioma has not been well understood. Therefore, we sought to comprehensively examine the genetic interaction between RTEL1 variants and risk of glioma with respect to defined histological and molecular subtypes. We employed a case-control study involving 250 adult glioma patients with previous molecular alterations and 375 population–based controls within Korean populations. Statistical analyses on the association between RTEL1 single nucleotide polymorphisms (SNPs) and glioma risk were conducted using unconditional logistic regression. Additional conditional and stepwise analyses were performed on significant RTEL1 SNPs. We detected significant associations (Bonferroni P < .05) between six SNPs (rs6089953, rs3848669, rs6010620, rs3787089, rs6062302, and rs115303435) and risk of glioma in the Korean subjects. The two coding variants, rs6062302 (D664D) and rs115303435 (A1059T), were plausibly causal variants and were independent among the significantly associated RTEL1 variants. The glioma subgroup analyses showed that the causal variants (rs6062302 and rs115303435) may be associated with increased risk of glioma regardless of histological grades and molecular alterations. This study provides a deeper understanding of relationships between RTEL1 variants and risk of glioma. Further studies are required to ascertain the impact of those variants on glioma susceptibility.

Original languageEnglish
Article numbere0207660
JournalPloS one
Volume13
Issue number11
DOIs
Publication statusPublished - 2018 Nov 1

Fingerprint

telomeres
Telomere
Glioma
Elongation
Population
Polymorphism
single nucleotide polymorphism
Nucleotides
Single Nucleotide Polymorphism
case-control studies
Logistics
loci
Case-Control Studies
Logistic Models

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Namgoong, S., Cheong, H. S., Kim, J. H., Kim, L. H., Seo, J. Y., Kang, S-G., ... Shin, H. D. (2018). Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population. PloS one, 13(11), [e0207660]. https://doi.org/10.1371/journal.pone.0207660
Namgoong, Suhg ; Cheong, Hyun Sub ; Kim, Jeong Hyun ; Kim, Lyoung Hyo ; Seo, Jung Yeon ; Kang, Seok-Gu ; Yoon, Seon Jin ; Kim, SeHoon ; Chang, Jong Hee ; Shin, Hyoung Doo. / Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population. In: PloS one. 2018 ; Vol. 13, No. 11.
@article{8d5b51cfeb2a4cd78fb094156bef35c1,
title = "Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population",
abstract = "Previous studies have identified multiple loci for inherited susceptibility to glioma development, including the regulator of telomere elongation helicase 1 (RTEL1). However, the association between RTEL1 variants and risk of glioma has not been well understood. Therefore, we sought to comprehensively examine the genetic interaction between RTEL1 variants and risk of glioma with respect to defined histological and molecular subtypes. We employed a case-control study involving 250 adult glioma patients with previous molecular alterations and 375 population–based controls within Korean populations. Statistical analyses on the association between RTEL1 single nucleotide polymorphisms (SNPs) and glioma risk were conducted using unconditional logistic regression. Additional conditional and stepwise analyses were performed on significant RTEL1 SNPs. We detected significant associations (Bonferroni P < .05) between six SNPs (rs6089953, rs3848669, rs6010620, rs3787089, rs6062302, and rs115303435) and risk of glioma in the Korean subjects. The two coding variants, rs6062302 (D664D) and rs115303435 (A1059T), were plausibly causal variants and were independent among the significantly associated RTEL1 variants. The glioma subgroup analyses showed that the causal variants (rs6062302 and rs115303435) may be associated with increased risk of glioma regardless of histological grades and molecular alterations. This study provides a deeper understanding of relationships between RTEL1 variants and risk of glioma. Further studies are required to ascertain the impact of those variants on glioma susceptibility.",
author = "Suhg Namgoong and Cheong, {Hyun Sub} and Kim, {Jeong Hyun} and Kim, {Lyoung Hyo} and Seo, {Jung Yeon} and Seok-Gu Kang and Yoon, {Seon Jin} and SeHoon Kim and Chang, {Jong Hee} and Shin, {Hyoung Doo}",
year = "2018",
month = "11",
day = "1",
doi = "10.1371/journal.pone.0207660",
language = "English",
volume = "13",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

Namgoong, S, Cheong, HS, Kim, JH, Kim, LH, Seo, JY, Kang, S-G, Yoon, SJ, Kim, S, Chang, JH & Shin, HD 2018, 'Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population', PloS one, vol. 13, no. 11, e0207660. https://doi.org/10.1371/journal.pone.0207660

Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population. / Namgoong, Suhg; Cheong, Hyun Sub; Kim, Jeong Hyun; Kim, Lyoung Hyo; Seo, Jung Yeon; Kang, Seok-Gu; Yoon, Seon Jin; Kim, SeHoon; Chang, Jong Hee; Shin, Hyoung Doo.

In: PloS one, Vol. 13, No. 11, e0207660, 01.11.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population

AU - Namgoong, Suhg

AU - Cheong, Hyun Sub

AU - Kim, Jeong Hyun

AU - Kim, Lyoung Hyo

AU - Seo, Jung Yeon

AU - Kang, Seok-Gu

AU - Yoon, Seon Jin

AU - Kim, SeHoon

AU - Chang, Jong Hee

AU - Shin, Hyoung Doo

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Previous studies have identified multiple loci for inherited susceptibility to glioma development, including the regulator of telomere elongation helicase 1 (RTEL1). However, the association between RTEL1 variants and risk of glioma has not been well understood. Therefore, we sought to comprehensively examine the genetic interaction between RTEL1 variants and risk of glioma with respect to defined histological and molecular subtypes. We employed a case-control study involving 250 adult glioma patients with previous molecular alterations and 375 population–based controls within Korean populations. Statistical analyses on the association between RTEL1 single nucleotide polymorphisms (SNPs) and glioma risk were conducted using unconditional logistic regression. Additional conditional and stepwise analyses were performed on significant RTEL1 SNPs. We detected significant associations (Bonferroni P < .05) between six SNPs (rs6089953, rs3848669, rs6010620, rs3787089, rs6062302, and rs115303435) and risk of glioma in the Korean subjects. The two coding variants, rs6062302 (D664D) and rs115303435 (A1059T), were plausibly causal variants and were independent among the significantly associated RTEL1 variants. The glioma subgroup analyses showed that the causal variants (rs6062302 and rs115303435) may be associated with increased risk of glioma regardless of histological grades and molecular alterations. This study provides a deeper understanding of relationships between RTEL1 variants and risk of glioma. Further studies are required to ascertain the impact of those variants on glioma susceptibility.

AB - Previous studies have identified multiple loci for inherited susceptibility to glioma development, including the regulator of telomere elongation helicase 1 (RTEL1). However, the association between RTEL1 variants and risk of glioma has not been well understood. Therefore, we sought to comprehensively examine the genetic interaction between RTEL1 variants and risk of glioma with respect to defined histological and molecular subtypes. We employed a case-control study involving 250 adult glioma patients with previous molecular alterations and 375 population–based controls within Korean populations. Statistical analyses on the association between RTEL1 single nucleotide polymorphisms (SNPs) and glioma risk were conducted using unconditional logistic regression. Additional conditional and stepwise analyses were performed on significant RTEL1 SNPs. We detected significant associations (Bonferroni P < .05) between six SNPs (rs6089953, rs3848669, rs6010620, rs3787089, rs6062302, and rs115303435) and risk of glioma in the Korean subjects. The two coding variants, rs6062302 (D664D) and rs115303435 (A1059T), were plausibly causal variants and were independent among the significantly associated RTEL1 variants. The glioma subgroup analyses showed that the causal variants (rs6062302 and rs115303435) may be associated with increased risk of glioma regardless of histological grades and molecular alterations. This study provides a deeper understanding of relationships between RTEL1 variants and risk of glioma. Further studies are required to ascertain the impact of those variants on glioma susceptibility.

UR - http://www.scopus.com/inward/record.url?scp=85056940995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056940995&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0207660

DO - 10.1371/journal.pone.0207660

M3 - Article

VL - 13

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 11

M1 - e0207660

ER -