Association between bacterial vaginosis and cervical intraepithelial neoplasia

Ka Hyun Nam, Young Tae Kim, Soo Rim Kim, Sang Wun Kim, Jae Wook Kim, Mi Kyung Lee, Eun Ji Nam, Yong Wook Jung

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine whether the presence of bacterial vaginosis (BV) is associated with cervical intraepithelial neoplasia (CIN) and human papilloma virus (HPV) infection. Methods: A total of 588 women who had abnormal Pap smears and had finally undergone loop electrosurgical excision procedure (LEEP) in our institute from September 2002 to May 2006 were selected. The screening tests for BV were done in 552 of the 588, and BV was diagnosed if three of the following four findings were satisfied: presence of abnormal discharge, vaginal pH>4.5, presence of clue cells, positive amine or whiff test. Five hundred and five patients had HPV typing tests by the HPV DNA chip. Forty two patients diagnosed with invasive cancer were excluded from this study. CIN was subdivided into low-grade CIN (CIN I) and high-grade CIN (CIN II/III) groups. Results: There was no statistically significant difference in patient characteristics between BV-present and BV-absent group. The incidence of CIN was significantly higher in the BV-present group (p=0.043), however, no statistical significance of BV on CIN was observed on multivariate analysis. HPV infection showed no significant relationship with BV. BV with or without HPV infection did not influence the incidence of CIN, regardless of the severity. Conclusion: There was significant correlation between BV and the presence of CIN, regardless of the severity of CIN. In addition, there was no significant association between the presence of BV and HPV infection.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalJournal of Gynecologic Oncology
Volume20
Issue number1
DOIs
Publication statusPublished - 2009 Mar 1

Fingerprint

Bacterial Vaginosis
Cervical Intraepithelial Neoplasia
Papillomaviridae
Virus Diseases
Vaginal Discharge
Papanicolaou Test
Incidence
Oligonucleotide Array Sequence Analysis
Amines
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Nam, Ka Hyun ; Kim, Young Tae ; Kim, Soo Rim ; Kim, Sang Wun ; Kim, Jae Wook ; Lee, Mi Kyung ; Nam, Eun Ji ; Jung, Yong Wook. / Association between bacterial vaginosis and cervical intraepithelial neoplasia. In: Journal of Gynecologic Oncology. 2009 ; Vol. 20, No. 1. pp. 39-43.
@article{b79d3d9573ef4166a6d9e343f6b46b79,
title = "Association between bacterial vaginosis and cervical intraepithelial neoplasia",
abstract = "Objective: The aim of this study was to determine whether the presence of bacterial vaginosis (BV) is associated with cervical intraepithelial neoplasia (CIN) and human papilloma virus (HPV) infection. Methods: A total of 588 women who had abnormal Pap smears and had finally undergone loop electrosurgical excision procedure (LEEP) in our institute from September 2002 to May 2006 were selected. The screening tests for BV were done in 552 of the 588, and BV was diagnosed if three of the following four findings were satisfied: presence of abnormal discharge, vaginal pH>4.5, presence of clue cells, positive amine or whiff test. Five hundred and five patients had HPV typing tests by the HPV DNA chip. Forty two patients diagnosed with invasive cancer were excluded from this study. CIN was subdivided into low-grade CIN (CIN I) and high-grade CIN (CIN II/III) groups. Results: There was no statistically significant difference in patient characteristics between BV-present and BV-absent group. The incidence of CIN was significantly higher in the BV-present group (p=0.043), however, no statistical significance of BV on CIN was observed on multivariate analysis. HPV infection showed no significant relationship with BV. BV with or without HPV infection did not influence the incidence of CIN, regardless of the severity. Conclusion: There was significant correlation between BV and the presence of CIN, regardless of the severity of CIN. In addition, there was no significant association between the presence of BV and HPV infection.",
author = "Nam, {Ka Hyun} and Kim, {Young Tae} and Kim, {Soo Rim} and Kim, {Sang Wun} and Kim, {Jae Wook} and Lee, {Mi Kyung} and Nam, {Eun Ji} and Jung, {Yong Wook}",
year = "2009",
month = "3",
day = "1",
doi = "10.3802/jgo.2009.20.1.39",
language = "English",
volume = "20",
pages = "39--43",
journal = "Journal of Gynecologic Oncology",
issn = "2005-0380",
publisher = "Korean Society of Gynecologic Oncology and Colposcopy",
number = "1",

}

Association between bacterial vaginosis and cervical intraepithelial neoplasia. / Nam, Ka Hyun; Kim, Young Tae; Kim, Soo Rim; Kim, Sang Wun; Kim, Jae Wook; Lee, Mi Kyung; Nam, Eun Ji; Jung, Yong Wook.

In: Journal of Gynecologic Oncology, Vol. 20, No. 1, 01.03.2009, p. 39-43.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between bacterial vaginosis and cervical intraepithelial neoplasia

AU - Nam, Ka Hyun

AU - Kim, Young Tae

AU - Kim, Soo Rim

AU - Kim, Sang Wun

AU - Kim, Jae Wook

AU - Lee, Mi Kyung

AU - Nam, Eun Ji

AU - Jung, Yong Wook

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Objective: The aim of this study was to determine whether the presence of bacterial vaginosis (BV) is associated with cervical intraepithelial neoplasia (CIN) and human papilloma virus (HPV) infection. Methods: A total of 588 women who had abnormal Pap smears and had finally undergone loop electrosurgical excision procedure (LEEP) in our institute from September 2002 to May 2006 were selected. The screening tests for BV were done in 552 of the 588, and BV was diagnosed if three of the following four findings were satisfied: presence of abnormal discharge, vaginal pH>4.5, presence of clue cells, positive amine or whiff test. Five hundred and five patients had HPV typing tests by the HPV DNA chip. Forty two patients diagnosed with invasive cancer were excluded from this study. CIN was subdivided into low-grade CIN (CIN I) and high-grade CIN (CIN II/III) groups. Results: There was no statistically significant difference in patient characteristics between BV-present and BV-absent group. The incidence of CIN was significantly higher in the BV-present group (p=0.043), however, no statistical significance of BV on CIN was observed on multivariate analysis. HPV infection showed no significant relationship with BV. BV with or without HPV infection did not influence the incidence of CIN, regardless of the severity. Conclusion: There was significant correlation between BV and the presence of CIN, regardless of the severity of CIN. In addition, there was no significant association between the presence of BV and HPV infection.

AB - Objective: The aim of this study was to determine whether the presence of bacterial vaginosis (BV) is associated with cervical intraepithelial neoplasia (CIN) and human papilloma virus (HPV) infection. Methods: A total of 588 women who had abnormal Pap smears and had finally undergone loop electrosurgical excision procedure (LEEP) in our institute from September 2002 to May 2006 were selected. The screening tests for BV were done in 552 of the 588, and BV was diagnosed if three of the following four findings were satisfied: presence of abnormal discharge, vaginal pH>4.5, presence of clue cells, positive amine or whiff test. Five hundred and five patients had HPV typing tests by the HPV DNA chip. Forty two patients diagnosed with invasive cancer were excluded from this study. CIN was subdivided into low-grade CIN (CIN I) and high-grade CIN (CIN II/III) groups. Results: There was no statistically significant difference in patient characteristics between BV-present and BV-absent group. The incidence of CIN was significantly higher in the BV-present group (p=0.043), however, no statistical significance of BV on CIN was observed on multivariate analysis. HPV infection showed no significant relationship with BV. BV with or without HPV infection did not influence the incidence of CIN, regardless of the severity. Conclusion: There was significant correlation between BV and the presence of CIN, regardless of the severity of CIN. In addition, there was no significant association between the presence of BV and HPV infection.

UR - http://www.scopus.com/inward/record.url?scp=77953459403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953459403&partnerID=8YFLogxK

U2 - 10.3802/jgo.2009.20.1.39

DO - 10.3802/jgo.2009.20.1.39

M3 - Article

C2 - 19471662

AN - SCOPUS:77953459403

VL - 20

SP - 39

EP - 43

JO - Journal of Gynecologic Oncology

JF - Journal of Gynecologic Oncology

SN - 2005-0380

IS - 1

ER -