Association between Bethesda Categories and Ultrasound Features of Conventional Papillary Thyroid Carcinoma

Ga Ram Kim, Eun Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon

Research output: Contribution to journalArticle

Abstract

The association between categories 3, 5 and 6 of the Bethesda System for Reporting Thyroid Cytopathology and the clinical and ultrasonography (US) features of conventional papillary thyroid carcinoma (PTC) was evaluated. We included 2005 patients diagnosed with conventional PTC at surgery and Bethesda categories 3, 5 and 6 at pre-operative US-guided fine-needle aspiration. Multinomial regression analysis was performed to determine the odds ratio (ORs) of each US feature associated with category 3 or 5, with category 6 as reference. Category 3 and 5 PTCs were smaller (ORs = 0.925 and 0.937) and did not exhibit marked hypo-echogenicity (ORs = 0.341 and 0.268) compared with category 6 PTCs. Category 3 and 5 PTCs exhibited significant macrocalcification (ORs = 2.372 and 1.594) and heterogeneous parenchyma (OR = 1.265 in category 5). In conclusion, conventional PTCs pre-operatively aspirated as Bethesda category 3, 5 or 6 significantly differ in size, macrocalcification, underlying thyroid parenchymal echogenicity and final assessment of US features.

Original languageEnglish
Pages (from-to)1066-1074
Number of pages9
JournalUltrasound in Medicine and Biology
Volume42
Issue number5
DOIs
Publication statusPublished - 2016 May 1

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Factor IX
cancer
Odds Ratio
Ultrasonography
Thyroid Gland
Fine Needle Biopsy
Regression Analysis
Papillary Thyroid cancer
surgery
needles
regression analysis
vacuum

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

Cite this

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abstract = "The association between categories 3, 5 and 6 of the Bethesda System for Reporting Thyroid Cytopathology and the clinical and ultrasonography (US) features of conventional papillary thyroid carcinoma (PTC) was evaluated. We included 2005 patients diagnosed with conventional PTC at surgery and Bethesda categories 3, 5 and 6 at pre-operative US-guided fine-needle aspiration. Multinomial regression analysis was performed to determine the odds ratio (ORs) of each US feature associated with category 3 or 5, with category 6 as reference. Category 3 and 5 PTCs were smaller (ORs = 0.925 and 0.937) and did not exhibit marked hypo-echogenicity (ORs = 0.341 and 0.268) compared with category 6 PTCs. Category 3 and 5 PTCs exhibited significant macrocalcification (ORs = 2.372 and 1.594) and heterogeneous parenchyma (OR = 1.265 in category 5). In conclusion, conventional PTCs pre-operatively aspirated as Bethesda category 3, 5 or 6 significantly differ in size, macrocalcification, underlying thyroid parenchymal echogenicity and final assessment of US features.",
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Association between Bethesda Categories and Ultrasound Features of Conventional Papillary Thyroid Carcinoma. / Kim, Ga Ram; Kim, Eun Kyung; Kwak, Jin Young; Yoon, Jung Hyun; Moon, Hee Jung.

In: Ultrasound in Medicine and Biology, Vol. 42, No. 5, 01.05.2016, p. 1066-1074.

Research output: Contribution to journalArticle

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