Association between blood pressure variability and inflammatory marker in hypertensive patients

Kwang Il Kim, Jae Hee Lee, Hyuk Jae Chang, Young Seok Cho, Tae Jin Youn, Woo Young Chung, In Ho Chae, Dong Ju Choi, Un Park Kyoung, Cheol Ho Kim

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Background: Blood pressure (BP) variability has been reported to be associated with hypertensive target organ damage and cardiovascular events. However, the exact mechanism linking BP variability and organ damage is uncertain. This study was designed to investigate the association between BP variability and inflammatory marker in hypertensive patients. Methods and Results: Fifty-two hypertensive patients (28 men, 55.9±1.5 years) completed 24-h ambulatory BP monitoring. Inflammatory markers were evaluated by measuring plasma levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay and high sensitive C-reactive protein (hs-CRP) by particle-enhanced light-scattering immunoassay. BP variability was obtained by calculating within-subject standard deviation (SD) and coefficient of variation of BP. Subjects were grouped into fertiles according to IL-6, TNF-α, and hs-CRP levels. A significant association between ambulatory BP and TNF-α level was identified (P for trend=0.011). In contrast, no association was observed between BP and IL-6 level; however, BP variability index was linked to IL-6 level (P for trend =0.046). The association between inflammatory marker and pattern of diurnal variation was investigated. The hs-CRP concentration was significantly higher in the riser group compared with the dipper group. However, IL-6 and TNF-α levels did not differ among the different diurnal variation groups. Correlation analysis showed varying associations between IL-6 and TNF-α. TNF-α level correlated with the BP index; however, IL-6 level correlated with the BP variability index. Multiple linear regression models revealed that the SD of daytime systolic BP (β=0.065, p=0.001) and age (β=0.024, p=0.016) were all positively and significantly related to IL-6. In contrast, only daytime diastolic BP (β=0.029, p=0.002) was independently related to TNF-α. Conclusion: Inflammatory markers are associated with BP variability in hypertensive patients. This finding implies that inflammation may be a mediator for the link between BP variability and target organ damage.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalCirculation Journal
Volume72
Issue number2
DOIs
Publication statusPublished - 2008 Mar 27

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Blood Pressure
Interleukin-6
Tumor Necrosis Factor-alpha
C-Reactive Protein
Linear Models
Ambulatory Blood Pressure Monitoring
Immunoassay
Enzyme-Linked Immunosorbent Assay
Inflammation
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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kim, Kwang Il ; Lee, Jae Hee ; Chang, Hyuk Jae ; Cho, Young Seok ; Youn, Tae Jin ; Chung, Woo Young ; Chae, In Ho ; Choi, Dong Ju ; Kyoung, Un Park ; Kim, Cheol Ho. / Association between blood pressure variability and inflammatory marker in hypertensive patients. In: Circulation Journal. 2008 ; Vol. 72, No. 2. pp. 293-298.
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title = "Association between blood pressure variability and inflammatory marker in hypertensive patients",
abstract = "Background: Blood pressure (BP) variability has been reported to be associated with hypertensive target organ damage and cardiovascular events. However, the exact mechanism linking BP variability and organ damage is uncertain. This study was designed to investigate the association between BP variability and inflammatory marker in hypertensive patients. Methods and Results: Fifty-two hypertensive patients (28 men, 55.9±1.5 years) completed 24-h ambulatory BP monitoring. Inflammatory markers were evaluated by measuring plasma levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay and high sensitive C-reactive protein (hs-CRP) by particle-enhanced light-scattering immunoassay. BP variability was obtained by calculating within-subject standard deviation (SD) and coefficient of variation of BP. Subjects were grouped into fertiles according to IL-6, TNF-α, and hs-CRP levels. A significant association between ambulatory BP and TNF-α level was identified (P for trend=0.011). In contrast, no association was observed between BP and IL-6 level; however, BP variability index was linked to IL-6 level (P for trend =0.046). The association between inflammatory marker and pattern of diurnal variation was investigated. The hs-CRP concentration was significantly higher in the riser group compared with the dipper group. However, IL-6 and TNF-α levels did not differ among the different diurnal variation groups. Correlation analysis showed varying associations between IL-6 and TNF-α. TNF-α level correlated with the BP index; however, IL-6 level correlated with the BP variability index. Multiple linear regression models revealed that the SD of daytime systolic BP (β=0.065, p=0.001) and age (β=0.024, p=0.016) were all positively and significantly related to IL-6. In contrast, only daytime diastolic BP (β=0.029, p=0.002) was independently related to TNF-α. Conclusion: Inflammatory markers are associated with BP variability in hypertensive patients. This finding implies that inflammation may be a mediator for the link between BP variability and target organ damage.",
author = "Kim, {Kwang Il} and Lee, {Jae Hee} and Chang, {Hyuk Jae} and Cho, {Young Seok} and Youn, {Tae Jin} and Chung, {Woo Young} and Chae, {In Ho} and Choi, {Dong Ju} and Kyoung, {Un Park} and Kim, {Cheol Ho}",
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Kim, KI, Lee, JH, Chang, HJ, Cho, YS, Youn, TJ, Chung, WY, Chae, IH, Choi, DJ, Kyoung, UP & Kim, CH 2008, 'Association between blood pressure variability and inflammatory marker in hypertensive patients', Circulation Journal, vol. 72, no. 2, pp. 293-298. https://doi.org/10.1253/circj.72.293

Association between blood pressure variability and inflammatory marker in hypertensive patients. / Kim, Kwang Il; Lee, Jae Hee; Chang, Hyuk Jae; Cho, Young Seok; Youn, Tae Jin; Chung, Woo Young; Chae, In Ho; Choi, Dong Ju; Kyoung, Un Park; Kim, Cheol Ho.

In: Circulation Journal, Vol. 72, No. 2, 27.03.2008, p. 293-298.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between blood pressure variability and inflammatory marker in hypertensive patients

AU - Kim, Kwang Il

AU - Lee, Jae Hee

AU - Chang, Hyuk Jae

AU - Cho, Young Seok

AU - Youn, Tae Jin

AU - Chung, Woo Young

AU - Chae, In Ho

AU - Choi, Dong Ju

AU - Kyoung, Un Park

AU - Kim, Cheol Ho

PY - 2008/3/27

Y1 - 2008/3/27

N2 - Background: Blood pressure (BP) variability has been reported to be associated with hypertensive target organ damage and cardiovascular events. However, the exact mechanism linking BP variability and organ damage is uncertain. This study was designed to investigate the association between BP variability and inflammatory marker in hypertensive patients. Methods and Results: Fifty-two hypertensive patients (28 men, 55.9±1.5 years) completed 24-h ambulatory BP monitoring. Inflammatory markers were evaluated by measuring plasma levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay and high sensitive C-reactive protein (hs-CRP) by particle-enhanced light-scattering immunoassay. BP variability was obtained by calculating within-subject standard deviation (SD) and coefficient of variation of BP. Subjects were grouped into fertiles according to IL-6, TNF-α, and hs-CRP levels. A significant association between ambulatory BP and TNF-α level was identified (P for trend=0.011). In contrast, no association was observed between BP and IL-6 level; however, BP variability index was linked to IL-6 level (P for trend =0.046). The association between inflammatory marker and pattern of diurnal variation was investigated. The hs-CRP concentration was significantly higher in the riser group compared with the dipper group. However, IL-6 and TNF-α levels did not differ among the different diurnal variation groups. Correlation analysis showed varying associations between IL-6 and TNF-α. TNF-α level correlated with the BP index; however, IL-6 level correlated with the BP variability index. Multiple linear regression models revealed that the SD of daytime systolic BP (β=0.065, p=0.001) and age (β=0.024, p=0.016) were all positively and significantly related to IL-6. In contrast, only daytime diastolic BP (β=0.029, p=0.002) was independently related to TNF-α. Conclusion: Inflammatory markers are associated with BP variability in hypertensive patients. This finding implies that inflammation may be a mediator for the link between BP variability and target organ damage.

AB - Background: Blood pressure (BP) variability has been reported to be associated with hypertensive target organ damage and cardiovascular events. However, the exact mechanism linking BP variability and organ damage is uncertain. This study was designed to investigate the association between BP variability and inflammatory marker in hypertensive patients. Methods and Results: Fifty-two hypertensive patients (28 men, 55.9±1.5 years) completed 24-h ambulatory BP monitoring. Inflammatory markers were evaluated by measuring plasma levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α by enzyme-linked immunosorbent assay and high sensitive C-reactive protein (hs-CRP) by particle-enhanced light-scattering immunoassay. BP variability was obtained by calculating within-subject standard deviation (SD) and coefficient of variation of BP. Subjects were grouped into fertiles according to IL-6, TNF-α, and hs-CRP levels. A significant association between ambulatory BP and TNF-α level was identified (P for trend=0.011). In contrast, no association was observed between BP and IL-6 level; however, BP variability index was linked to IL-6 level (P for trend =0.046). The association between inflammatory marker and pattern of diurnal variation was investigated. The hs-CRP concentration was significantly higher in the riser group compared with the dipper group. However, IL-6 and TNF-α levels did not differ among the different diurnal variation groups. Correlation analysis showed varying associations between IL-6 and TNF-α. TNF-α level correlated with the BP index; however, IL-6 level correlated with the BP variability index. Multiple linear regression models revealed that the SD of daytime systolic BP (β=0.065, p=0.001) and age (β=0.024, p=0.016) were all positively and significantly related to IL-6. In contrast, only daytime diastolic BP (β=0.029, p=0.002) was independently related to TNF-α. Conclusion: Inflammatory markers are associated with BP variability in hypertensive patients. This finding implies that inflammation may be a mediator for the link between BP variability and target organ damage.

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