Association between body mass index and cortical thickness: Among elderly cognitively normal men and women

Hojeong Kim, Changsoo Kim, Sang Won Seo, Duk L. Na, Hee Jin Kim, Mira Kang, Hee Young Shin, Seong Kyung Cho, Sang Eon Park, Jeongmin Lee, Jung Won Hwang, Seun Jeon, Jong Min Lee, Geon Ha Kim, Hanna Cho, Byoung Seok Ye, Young Noh, Cindy W. Yoon, Eliseo Guallar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: There is increasing evidence of a relationship between underweight or obesity and dementia risk. Several studies have investigated the relationship between body weight and brain atrophy, a pathological change preceding dementia, but their results are inconsistent. Therefore, we aimed to evaluate the relationship between body mass index (BMI) and cortical atrophy among cognitively normal participants. Methods: We recruited cognitively normal participants (n = 1,111) who underwent medical checkups and detailed neurologic screening, including magnetic resonance imaging (MRI) in the health screening visits between September 2008 and December 2011. The main outcome was cortical thickness measured using MRI. The number of subjects with five BMI groups in men/women was 9/9, 148/258, 185/128, 149/111, and 64/50 in underweight, normal, overweight, mild obesity, and moderate to severe obesity, respectively. Linear and non-linear relationships between BMI and cortical thickness were examined using multiple linear regression analysis and generalized additive models after adjustment for potential confounders. Results: Among men, underweight participants showed significant cortical thinning in the frontal and temporal regions compared to normal weight participants, while overweight and mildly obese participants had greater cortical thicknesses in the frontal region and the frontal, temporal, and occipital regions, respectively. However, cortical thickness in each brain region was not significantly different in normal weight and moderate to severe obesity groups. Among women, the association between BMI and cortical thickness was not statistically significant. Conclusions: Our findings suggested that underweight might be an important risk factor for pathological changes in the brain, while overweight or mild obesity may be inversely associated with cortical atrophy in cognitively normal elderly males.

Original languageEnglish
Pages (from-to)121-130
Number of pages10
JournalInternational Psychogeriatrics
Volume27
Issue number1
DOIs
Publication statusPublished - 2015 Jan 12

Fingerprint

Thinness
Body Mass Index
Atrophy
Morbid Obesity
Obesity
Temporal Lobe
Dementia
Brain
Magnetic Resonance Imaging
Weights and Measures
Occipital Lobe
Nervous System
Linear Models
Body Weight
Regression Analysis
Health

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Kim, Hojeong ; Kim, Changsoo ; Seo, Sang Won ; Na, Duk L. ; Kim, Hee Jin ; Kang, Mira ; Shin, Hee Young ; Cho, Seong Kyung ; Park, Sang Eon ; Lee, Jeongmin ; Hwang, Jung Won ; Jeon, Seun ; Lee, Jong Min ; Kim, Geon Ha ; Cho, Hanna ; Ye, Byoung Seok ; Noh, Young ; Yoon, Cindy W. ; Guallar, Eliseo. / Association between body mass index and cortical thickness : Among elderly cognitively normal men and women. In: International Psychogeriatrics. 2015 ; Vol. 27, No. 1. pp. 121-130.
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abstract = "Background: There is increasing evidence of a relationship between underweight or obesity and dementia risk. Several studies have investigated the relationship between body weight and brain atrophy, a pathological change preceding dementia, but their results are inconsistent. Therefore, we aimed to evaluate the relationship between body mass index (BMI) and cortical atrophy among cognitively normal participants. Methods: We recruited cognitively normal participants (n = 1,111) who underwent medical checkups and detailed neurologic screening, including magnetic resonance imaging (MRI) in the health screening visits between September 2008 and December 2011. The main outcome was cortical thickness measured using MRI. The number of subjects with five BMI groups in men/women was 9/9, 148/258, 185/128, 149/111, and 64/50 in underweight, normal, overweight, mild obesity, and moderate to severe obesity, respectively. Linear and non-linear relationships between BMI and cortical thickness were examined using multiple linear regression analysis and generalized additive models after adjustment for potential confounders. Results: Among men, underweight participants showed significant cortical thinning in the frontal and temporal regions compared to normal weight participants, while overweight and mildly obese participants had greater cortical thicknesses in the frontal region and the frontal, temporal, and occipital regions, respectively. However, cortical thickness in each brain region was not significantly different in normal weight and moderate to severe obesity groups. Among women, the association between BMI and cortical thickness was not statistically significant. Conclusions: Our findings suggested that underweight might be an important risk factor for pathological changes in the brain, while overweight or mild obesity may be inversely associated with cortical atrophy in cognitively normal elderly males.",
author = "Hojeong Kim and Changsoo Kim and Seo, {Sang Won} and Na, {Duk L.} and Kim, {Hee Jin} and Mira Kang and Shin, {Hee Young} and Cho, {Seong Kyung} and Park, {Sang Eon} and Jeongmin Lee and Hwang, {Jung Won} and Seun Jeon and Lee, {Jong Min} and Kim, {Geon Ha} and Hanna Cho and Ye, {Byoung Seok} and Young Noh and Yoon, {Cindy W.} and Eliseo Guallar",
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Kim, H, Kim, C, Seo, SW, Na, DL, Kim, HJ, Kang, M, Shin, HY, Cho, SK, Park, SE, Lee, J, Hwang, JW, Jeon, S, Lee, JM, Kim, GH, Cho, H, Ye, BS, Noh, Y, Yoon, CW & Guallar, E 2015, 'Association between body mass index and cortical thickness: Among elderly cognitively normal men and women', International Psychogeriatrics, vol. 27, no. 1, pp. 121-130. https://doi.org/10.1017/S1041610214001744

Association between body mass index and cortical thickness : Among elderly cognitively normal men and women. / Kim, Hojeong; Kim, Changsoo; Seo, Sang Won; Na, Duk L.; Kim, Hee Jin; Kang, Mira; Shin, Hee Young; Cho, Seong Kyung; Park, Sang Eon; Lee, Jeongmin; Hwang, Jung Won; Jeon, Seun; Lee, Jong Min; Kim, Geon Ha; Cho, Hanna; Ye, Byoung Seok; Noh, Young; Yoon, Cindy W.; Guallar, Eliseo.

In: International Psychogeriatrics, Vol. 27, No. 1, 12.01.2015, p. 121-130.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between body mass index and cortical thickness

T2 - Among elderly cognitively normal men and women

AU - Kim, Hojeong

AU - Kim, Changsoo

AU - Seo, Sang Won

AU - Na, Duk L.

AU - Kim, Hee Jin

AU - Kang, Mira

AU - Shin, Hee Young

AU - Cho, Seong Kyung

AU - Park, Sang Eon

AU - Lee, Jeongmin

AU - Hwang, Jung Won

AU - Jeon, Seun

AU - Lee, Jong Min

AU - Kim, Geon Ha

AU - Cho, Hanna

AU - Ye, Byoung Seok

AU - Noh, Young

AU - Yoon, Cindy W.

AU - Guallar, Eliseo

PY - 2015/1/12

Y1 - 2015/1/12

N2 - Background: There is increasing evidence of a relationship between underweight or obesity and dementia risk. Several studies have investigated the relationship between body weight and brain atrophy, a pathological change preceding dementia, but their results are inconsistent. Therefore, we aimed to evaluate the relationship between body mass index (BMI) and cortical atrophy among cognitively normal participants. Methods: We recruited cognitively normal participants (n = 1,111) who underwent medical checkups and detailed neurologic screening, including magnetic resonance imaging (MRI) in the health screening visits between September 2008 and December 2011. The main outcome was cortical thickness measured using MRI. The number of subjects with five BMI groups in men/women was 9/9, 148/258, 185/128, 149/111, and 64/50 in underweight, normal, overweight, mild obesity, and moderate to severe obesity, respectively. Linear and non-linear relationships between BMI and cortical thickness were examined using multiple linear regression analysis and generalized additive models after adjustment for potential confounders. Results: Among men, underweight participants showed significant cortical thinning in the frontal and temporal regions compared to normal weight participants, while overweight and mildly obese participants had greater cortical thicknesses in the frontal region and the frontal, temporal, and occipital regions, respectively. However, cortical thickness in each brain region was not significantly different in normal weight and moderate to severe obesity groups. Among women, the association between BMI and cortical thickness was not statistically significant. Conclusions: Our findings suggested that underweight might be an important risk factor for pathological changes in the brain, while overweight or mild obesity may be inversely associated with cortical atrophy in cognitively normal elderly males.

AB - Background: There is increasing evidence of a relationship between underweight or obesity and dementia risk. Several studies have investigated the relationship between body weight and brain atrophy, a pathological change preceding dementia, but their results are inconsistent. Therefore, we aimed to evaluate the relationship between body mass index (BMI) and cortical atrophy among cognitively normal participants. Methods: We recruited cognitively normal participants (n = 1,111) who underwent medical checkups and detailed neurologic screening, including magnetic resonance imaging (MRI) in the health screening visits between September 2008 and December 2011. The main outcome was cortical thickness measured using MRI. The number of subjects with five BMI groups in men/women was 9/9, 148/258, 185/128, 149/111, and 64/50 in underweight, normal, overweight, mild obesity, and moderate to severe obesity, respectively. Linear and non-linear relationships between BMI and cortical thickness were examined using multiple linear regression analysis and generalized additive models after adjustment for potential confounders. Results: Among men, underweight participants showed significant cortical thinning in the frontal and temporal regions compared to normal weight participants, while overweight and mildly obese participants had greater cortical thicknesses in the frontal region and the frontal, temporal, and occipital regions, respectively. However, cortical thickness in each brain region was not significantly different in normal weight and moderate to severe obesity groups. Among women, the association between BMI and cortical thickness was not statistically significant. Conclusions: Our findings suggested that underweight might be an important risk factor for pathological changes in the brain, while overweight or mild obesity may be inversely associated with cortical atrophy in cognitively normal elderly males.

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