Association between C reactive protein level and depressive symptoms in an elderly Korean population: Korean Social Life, Health and Aging Project

Bo Mi Song, Ju Mi Lee, Wungrak Choi, Yoosik Youm, Sang Hui Chu, Yeong Ran Park, Hyeon Chang Kim

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Objective: The relationship between inflammatory markers and depressive symptoms has been reported inconsistently. Moreover, there were only a few studies conducted in an Asian population. The purpose of this study was to examine the association between C reactive protein (CRP) and depressive symptoms in an elderly Korean population. Design, setting and participants: This study used data from the Korean Social Life, Health and Aging Project Health Examination Cohort, which started in 2011. Among participants aged 60 or over recruited from a rural community, 569 (224 men and 345 women) without a history of stroke, angina pectoris, myocardial infarction or CRP≥20 mg/L were employed for cross-sectional analyses. As a marker of systemic inflammation, CRP was measured. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple linear regression analysis was used to investigate the relationship between CRP and depressive symptoms. Results: In men, CRP levels had significant associations with depressive symptoms before (β=0.420, p=0.010) and after (β=0.336, p=0.025) adjusting for age, body mass index, systolic blood pressure, number of comorbidities, smoking status, alcohol intake, marital status, education and sleep duration. However, in women, the association between CRP and depressive symptoms was not significant before (p=0.250) and after (p=0.256) adjustment. Conclusions: Our findings suggest that elevated CRP levels are independently associated with the presence of depressive symptoms in elderly Korean men.

Original languageEnglish
Article numbere006429
JournalBMJ open
Volume5
Issue number2
DOIs
Publication statusPublished - 2015

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C-Reactive Protein
Depression
Health
Population
Blood Pressure
Social Adjustment
Marital Status
Angina Pectoris
Rural Population
Comorbidity
Epidemiologic Studies
Linear Models
Sleep
Body Mass Index
Cross-Sectional Studies
Smoking
Stroke
Myocardial Infarction
Regression Analysis
Alcohols

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Association between C reactive protein level and depressive symptoms in an elderly Korean population: Korean Social Life, Health and Aging Project",
abstract = "Objective: The relationship between inflammatory markers and depressive symptoms has been reported inconsistently. Moreover, there were only a few studies conducted in an Asian population. The purpose of this study was to examine the association between C reactive protein (CRP) and depressive symptoms in an elderly Korean population. Design, setting and participants: This study used data from the Korean Social Life, Health and Aging Project Health Examination Cohort, which started in 2011. Among participants aged 60 or over recruited from a rural community, 569 (224 men and 345 women) without a history of stroke, angina pectoris, myocardial infarction or CRP≥20 mg/L were employed for cross-sectional analyses. As a marker of systemic inflammation, CRP was measured. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple linear regression analysis was used to investigate the relationship between CRP and depressive symptoms. Results: In men, CRP levels had significant associations with depressive symptoms before (β=0.420, p=0.010) and after (β=0.336, p=0.025) adjusting for age, body mass index, systolic blood pressure, number of comorbidities, smoking status, alcohol intake, marital status, education and sleep duration. However, in women, the association between CRP and depressive symptoms was not significant before (p=0.250) and after (p=0.256) adjustment. Conclusions: Our findings suggest that elevated CRP levels are independently associated with the presence of depressive symptoms in elderly Korean men.",
author = "Song, {Bo Mi} and Lee, {Ju Mi} and Wungrak Choi and Yoosik Youm and Chu, {Sang Hui} and Park, {Yeong Ran} and Kim, {Hyeon Chang}",
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Association between C reactive protein level and depressive symptoms in an elderly Korean population : Korean Social Life, Health and Aging Project. / Song, Bo Mi; Lee, Ju Mi; Choi, Wungrak; Youm, Yoosik; Chu, Sang Hui; Park, Yeong Ran; Kim, Hyeon Chang.

In: BMJ open, Vol. 5, No. 2, e006429, 2015.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Association between C reactive protein level and depressive symptoms in an elderly Korean population

T2 - Korean Social Life, Health and Aging Project

AU - Song, Bo Mi

AU - Lee, Ju Mi

AU - Choi, Wungrak

AU - Youm, Yoosik

AU - Chu, Sang Hui

AU - Park, Yeong Ran

AU - Kim, Hyeon Chang

PY - 2015

Y1 - 2015

N2 - Objective: The relationship between inflammatory markers and depressive symptoms has been reported inconsistently. Moreover, there were only a few studies conducted in an Asian population. The purpose of this study was to examine the association between C reactive protein (CRP) and depressive symptoms in an elderly Korean population. Design, setting and participants: This study used data from the Korean Social Life, Health and Aging Project Health Examination Cohort, which started in 2011. Among participants aged 60 or over recruited from a rural community, 569 (224 men and 345 women) without a history of stroke, angina pectoris, myocardial infarction or CRP≥20 mg/L were employed for cross-sectional analyses. As a marker of systemic inflammation, CRP was measured. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple linear regression analysis was used to investigate the relationship between CRP and depressive symptoms. Results: In men, CRP levels had significant associations with depressive symptoms before (β=0.420, p=0.010) and after (β=0.336, p=0.025) adjusting for age, body mass index, systolic blood pressure, number of comorbidities, smoking status, alcohol intake, marital status, education and sleep duration. However, in women, the association between CRP and depressive symptoms was not significant before (p=0.250) and after (p=0.256) adjustment. Conclusions: Our findings suggest that elevated CRP levels are independently associated with the presence of depressive symptoms in elderly Korean men.

AB - Objective: The relationship between inflammatory markers and depressive symptoms has been reported inconsistently. Moreover, there were only a few studies conducted in an Asian population. The purpose of this study was to examine the association between C reactive protein (CRP) and depressive symptoms in an elderly Korean population. Design, setting and participants: This study used data from the Korean Social Life, Health and Aging Project Health Examination Cohort, which started in 2011. Among participants aged 60 or over recruited from a rural community, 569 (224 men and 345 women) without a history of stroke, angina pectoris, myocardial infarction or CRP≥20 mg/L were employed for cross-sectional analyses. As a marker of systemic inflammation, CRP was measured. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple linear regression analysis was used to investigate the relationship between CRP and depressive symptoms. Results: In men, CRP levels had significant associations with depressive symptoms before (β=0.420, p=0.010) and after (β=0.336, p=0.025) adjusting for age, body mass index, systolic blood pressure, number of comorbidities, smoking status, alcohol intake, marital status, education and sleep duration. However, in women, the association between CRP and depressive symptoms was not significant before (p=0.250) and after (p=0.256) adjustment. Conclusions: Our findings suggest that elevated CRP levels are independently associated with the presence of depressive symptoms in elderly Korean men.

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